Plantar basal cell carcinoma in a patient with xeroderma pigmentosum: importance of dermoscopy for early diagnosis of nonpigmented skin cancer

Background: The purpose of this study was to formulate, characterize and in-vitro cytotoxicity of 5-Fluorouracil loaded controlled release nanoparticles for the treatment of skin cancer. The patents on nanoparticles (US8414926B1), (US61654404A), (WO2007150075A3) etc. helped in the selection polymers and method for the preparation of nanoparticles. Methods: In the present study nanoparticles were prepared by simple ionic gelation method using various concentrations of chitosan and sodium tripolyphosphate (TPP). Several process and formulation parameters were screened and optimized using 25-2 fractional factorial design. The prepared nanoparticles were evaluated for particle size, shape, charge, entrapment efficiency, crosslinking mechanism and drug release study. Results: The optimized 5-Fluorouracil loaded nanoparticle were found with particle size of of 320±2.1 nm, entrapment efficiency of 85.12%± 1.1% and Zeta potential of 29mv±1mv. Scanning electron microscopy and dynamic light scattering technique revealed spherical particles with uniform size. The invitro release profile showed controlled release up to 24 hr. Further study was carried using A375 basal cell carcinoma cell-line to elucidate the mechanism of its cytotoxicity by MTT assay. Conclusion: These results demonstrate that the possibility of delivering 5-Fluorouracil to skin with enhanced encapsulation efficiency indicating effectiveness of the formulation for treatment of basal cell carcinoma type of skin cancer.

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Formulation, Characterization and In vitro Cytotoxicity of 5-Fluorouracil Loaded Polymeric Electrospun Nanofibers for the Treatment of Skin Cancer

Recent Patents on Nanotechnology ◽

10.2174/1872210513666190314095643 ◽

2019 ◽

Vol 13 (2) ◽

pp. 114-128 ◽

Cited By ~ 2

Author(s):

Gayatri Patel ◽

Bindu K.N. Yadav

Keyword(s):

Skin Cancer ◽

Basal Cell Carcinoma ◽

Cell Viability ◽

Cell Carcinoma ◽

Basal Cell ◽

Fiber Diameter ◽

Electrospun Nanofibers ◽

In Vitro Cytotoxicity ◽

Fractional Factorial

Background: The purpose of this study was to formulate, characterize and conduct in vitro cytotoxicity of 5-fluorouracil loaded polymeric electrospun nanofibers for the treatment of skin cancer. The patents on electrospun nanofibers (US9393216B2), (US14146252), (WO2015003155A1) etc. helped in the selection of polymers and method for the preparation of nanofibers. Methods: In the present study, the fabrication of nanofibers was done using a blend of chitosan with polyvinyl alcohol and processed using the electrospinning technique. 5-fluorouracil with known chemotherapeutic potential in the treatment of skin cancer was used as a drug carrier. 24-1 fractional factorial screening design was employed to study the effect of independent variables like the concentration of the polymeric solution, applied voltage (kV), distance (cm), flow rate (ml / hr) on dependent variables like % entrapment efficiency and fiber diameter. Results: Scanning electron microscopy was used to characterize fiber diameter and morphology. Results showed that the fiber diameter of all batches was found in the range of 100-200 nm. The optimized batch results showed the fiber diameter of 162.7 nm with uniform fibers. The tensile strength obtained was 190±37 Mpa. Further in vitro and ex vivo drug release profile suggested a controlled release mechanism for an extended period of 24 hr. The 5-fluorouracil loaded electrospun nanofibers were found to decrease cell viability up to ≥50% over 24 hr, with the number of cells dropping by ~ 10% over 48 hr. As the cell viability was affected by the release of 5-fluorouracil, we believe that electrospun nanofibers are a promising drug delivery system for the treatment of Basal Cell Carcinoma (BCC) skin cancer. Conclusion: These results demonstrate the possibility of delivering 5-Fluorouracil loaded electrospun nanofiber to skin with enhanced encapsulation efficiency indicating the effectiveness of the formulation for the treatment of basal cell carcinoma type of skin cancer.

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Hugh Jackman vs. Skin Cancer Awareness Month: Promoting Public Interest in Basal Cell Carcinoma (Preprint)

10.2196/preprints.17965 ◽

2020 ◽

Author(s):

Trevor Torgerson ◽

Jennifer Austin ◽

Jam Khojasteh ◽

Matt Vassar

Keyword(s):

Social Media ◽

Skin Cancer ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Moving Average ◽

Public Awareness ◽

Sun Exposure ◽

Cancer Awareness ◽

Autoregressive Integrated Moving Average

BACKGROUND Public awareness for BCC is particularly important, as its major risk factors — increased sun exposure and number of sunburns — are largely preventable. OBJECTIVE Determine whether social media posts from celebrities has an affect on public awareness of basal cell carcinoma. METHODS We used Google Trends to investigate whether public awareness for basal cell carcinoma (BCC) increased following social media posts from Hugh Jackman. To forecast the expected search interest for BCC, melanoma and sunscreen in the event that each celebrity had not posted on social media, we used the autoregressive integrated moving average (ARIMA) algorithm. RESULTS We found that social media posts from Hugh Jackman, a well-known actor, increased relative search interest above the expected search interest calculated using an ARIMA forecasting model. CONCLUSIONS Our results also suggest that increasing awareness by Skin Cancer Awareness Month may be less effective for BCC, but a celebrity spokesperson has the potential to increase awareness. BCC is largely preventable, so increasing awareness could lead to a decrease in incidence.

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Geographic Variation and Risk of Skin Cancer in US WomenDifferences Between Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma

Archives of Internal Medicine ◽

10.1001/archinte.168.5.501 ◽

2008 ◽

Vol 168 (5) ◽

pp. 501 ◽

Cited By ~ 46

Author(s):

Abrar A. Qureshi

Keyword(s):

Squamous Cell Carcinoma ◽

Skin Cancer ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Geographic Variation ◽

Squamous Cell ◽

Basal Cell

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Erratum: Mohs Surgery versus Standard Local Excision for Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma Skin Cancer

Facial Plastic Surgery ◽

10.1055/s-0040-1721103 ◽

2020 ◽

Author(s):

Timothy M. Johnson ◽

Noah R. Smith

Keyword(s):

Squamous Cell Carcinoma ◽

Skin Cancer ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Local Excision ◽

Squamous Cell ◽

Basal Cell ◽

Mohs Surgery ◽

Carcinoma Squamous Cell ◽

Melanoma Skin

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Facial extensive ulcer

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.62.01.21 ◽

2016 ◽

Vol 62 (1) ◽

pp. 21-23 ◽

Cited By ~ 1

Author(s):

Pablo Fernández-Crehuet ◽

Ricardo Ruiz-Villaverde

Keyword(s):

Skin Cancer ◽

Basal Cell Carcinoma ◽

Aggressive Behavior ◽

Cell Carcinoma ◽

Basal Cell ◽

Clinical Case ◽

Pathological Characteristics

SUMMARY Basosquamous carcinoma (BSC), as described in 1910, is a distinctive variety of skin cancer and its etiology and pathological characteristics have generated much controversy over the years. Currently, BSC is considered a basal cell carcinoma (BCC) subtype with aggressive behavior and greater tendency for recurrence and metastases. We present a clinical case recently reported in our unit.

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Colonisation of basal cell carcinoma and actinic keratosis by malignant melanoma in situ in a patient with xeroderma pigmentosum variant

Clinics and Practice ◽

10.4081/cp.2012.e47 ◽

2012 ◽

Vol 2 (2) ◽

pp. 47 ◽

Cited By ~ 3

Author(s):

Louise J. Smith ◽

Ehab A. Husain

Keyword(s):

Malignant Melanoma ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Actinic Keratosis ◽

Xeroderma Pigmentosum ◽

Clinical Impression ◽

Anatomical Site ◽

History Of

Although malignant melanoma (MM) and both basal cell carcinoma (BCC) and actinic keratosis (AK) are sun-induced lesions, the coexistence of these entities at the same anatomical site (collision tumour) is exceedingly rare. We report the case of a 54-year-old woman with a known history of xeroderma pigmentosum variant (XPV) who presented with 2 separate skin lesions over the middle and upper right forearm, respectively. The clinical impression was that of BCCs or squamous cell lesions. On histological examination, both specimens showed features of melanoma <em>in situ </em>(MIS). In the first lesion, MIS merged with and colonised a superficial and focally invasive BCC. In the second lesion, MIS merged with an AK. No separate invasive nests of malignant melanoma were seen in either specimen. The atypical melanocytes were highlighted by Melan-A and HMB-45 immunostaining, whereas the epithelial cells in both the BCC and AK stained with the pancytokeratin MNF-116. The patient had a previous history of multiple MMs and non-melanomatous skin cancers and finally developed widespread metastatic malignant melanoma, which proved fatal. The rare and interesting phenomenon of collision tumours may pose diagnostic difficulties. To our knowledge, this is the first reported simultaneous presentation of cytologically malignant collision tumours in a patient with XPV.

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