The immune system in healthy adults and patients with atopic dermatitis seems to be affected differently by a probiotic intervention

2007 ◽  
Vol 0 (0) ◽  
pp. 071119182754004-??? ◽  
Author(s):  
A. Roessler (nee Klein) ◽  
U. Friedrich ◽  
H. Vogelsang ◽  
A. Bauer ◽  
M. Kaatz ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Healthy Adults ◽  
Probiotic Intervention

The Immune System and Atopic Dermatitis

2008 ◽  
Vol 27 (2) ◽  
pp. 138-143 ◽  
Author(s):  
Elif Dokmeci ◽  
Christina A. Herrick
Keyword(s):  
Atopic Dermatitis ◽  
Immune System

scholarly journals Potentials of probiotics in the treatment of food allergy – a review

2014 ◽  
Vol 32 (No. 3) ◽  
pp. 205-212 ◽  
Author(s):  
A. Patel ◽  
N. Shah
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Food Allergy ◽  
Immune System ◽  
Current Paper ◽  
Gastrointestinal Disorders ◽  
Recent Advances ◽  
Health Promoting ◽  
Treatment Of Food Allergy ◽  
Made In

Food allergy is an adverse immune response to some proteins in some foods. Probiotic, health promoting bacteria have gained much importance because of their innumerable benefits, particularly in the treatment of diarrhea, hypercholesterolemia, atopic dermatitis, eczema, and gastrointestinal disorders by strengthening the immune system. The current paper reviews recent advances made in the treatment of food allergy through employing probiotic or synbiotic therapy. The results of several reports are very promising suggesting probiotics can influence the immune system to curtail the allergic responses.

scholarly journals Modifications of the Innate Immune System in Atopic Dermatitis

2011 ◽  
Vol 3 (2) ◽  
pp. 131-141 ◽  
Author(s):  
Laura Maintz ◽  
Natalija Novak
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Innate Immune System ◽  
Innate Immune

scholarly journals Effectiveness ofLactobacillus helveticusandLactobacillus rhamnosusfor the management of antibiotic-associated diarrhoea in healthy adults: a randomised, double-blind, placebo-controlled trial

2016 ◽  
Vol 116 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Malkanthi Evans ◽  
Ryan P. Salewski ◽  
Mary C. Christman ◽  
Stephanie-Anne Girard ◽  
Thomas A. Tompkins
Keyword(s):  
Rating Scale ◽  
Gastrointestinal Symptoms ◽  
Healthy Adults ◽  
Lactobacillus Helveticus ◽  
Primary Study ◽  
Gastrointestinal Microbiota ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Probiotic Intervention ◽  
Antibiotic Associated Diarrhoea

AbstractBroad-spectrum antibiotic use can disrupt the gastrointestinal microbiota resulting in diarrhoea. Probiotics may be beneficial in managing this type of diarrhoea. The aim of this 10-week randomised, double-blind, placebo-controlled, parallel study was to investigate the effect ofLactobacillus helveticusR0052 andLactobacillus rhamnosusR0011 supplementation on antibiotic-associated diarrhoea in healthy adults. Subjects were randomised to receive 1 week of amoxicillin–clavulanic acid (875 mg/125 mg) once per day, plus a daily dose of 8×109colony-forming units of a multi-strain probiotic (n80) or placebo (n80). The probiotic or placebo intervention was maintained for 1 week after completion of the antibiotic. Primary study outcomes of consistency and frequency of bowel movements were not significantly different between the probiotic and placebo groups. The secondary outcomes of diarrhoea-like defecations, Gastrointestinal Symptoms Rating Scale scores, safety parameters and adverse events were not significantly different between the probiotic intervention and the placebo. Apost hocanalysis on the duration of diarrhoea-like defecations showed that probiotic intervention reduced the length of these events by 1 full day (probiotic, 2·70(sem0·36) d; placebo, 3·71 (sem0·36) d;P=0·037; effect size=0·52). In conclusion, this study provides novel evidence thatL. helveticusR0052 andL. rhamnosusR0011 supplementation significantly reduced the duration of diarrhoea-like defecations in healthy adults receiving antibiotics.

Cyclosporin-A in the treatment of atopic dermatitis: effects on the immune system and clinical efficiency

1994 ◽  
Vol 3 (3) ◽  
pp. 314-319 ◽  
Author(s):  
Silvio Masci ◽  
Claudio Feliciani ◽  
Massimo Gravante ◽  
Gianluca Proietto ◽  
Maria Andreassi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Cyclosporin A ◽  
Clinical Efficiency

The adaptive immune system in atopic dermatitis and implications on therapy

2016 ◽  
Vol 12 (7) ◽  
pp. 787-796 ◽  
Author(s):  
Lennart M. Roesner ◽  
Thomas Werfel ◽  
Annice Heratizadeh
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Adaptive Immune System ◽  
Adaptive Immune

scholarly journals Influence of intestinal microbiota on the immunopathogenesis of atopic dermatitis in children

2021 ◽  
pp. 4-11
Author(s):  
Alexander Viktorovich Zhestkov ◽  
Olga Olegovna Pobezhimova
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Intestinal Microbiota ◽  
Intestinal Microflora ◽  
Dynamic Equilibrium ◽  
Clinical Manifestations ◽  
Factors Affecting ◽  
Intestinal Dysbiosis ◽  
Human Intestinal Microbiota ◽  
Th1 Cytokines

Particular attention is paid to atopic dermatitis (AD) as one of the earliest and most frequent clinical manifestations of allergy in children. AD is a multifactorial disease, the development of which is closely related to genetic defects in the immune response and adverse environmental influences. It was found that the action of these factors determines the rate of development of AD, especially in young children. One of these factors is a violation of the intestinal microbiota, which plays an essential role in the development of the child's immune system and has a protective effect in the formation of atopy. It has been shown that 80-95% of patients with AD have intestinal dysbiosis, while, along with a deficiency of lactobacilli and bifidobacteria, there is an excessive growth of Staphilococcus. The use of modern molecular genetics technologies made it possible to obtain a fairly complete understanding of the number, genetic heterogeneity and complexity of the bacterial components of the intestinal microbiota, while clinical studies have shown the importance of its interactions with the host organism in the formation of various forms of pathology. It has been established that the human intestinal microbiota is an evolutionary set of microorganisms that exists as a balanced microecological system in which the symbiotic microflora is in dynamic equilibrium, forms microbial associations that occupy a certain ecological niche in it, and is one of the most important factors affecting human health. The gut microbiota plays an important role in the pathogenesis of atopic dermatitis, which causes immunosuppression, but the exact mechanism of its action is still unclear. It is widely known that probiotics act on the immune system. These are living microorganisms with immunomodulatory effects that stimulate Th1 cytokines and suppress Th2 responses, which are being investigated for the treatment of several diseases. The most commonly used probiotics are part of the intestinal microflora such as lactobacilli, bifidobacteria and enterococci. The purpose of this article: to systematize the information available today on the influence of the composition of the intestinal microflora on the immunopathogenesis of atopic dermatitis.

scholarly journals Staphylococcus pseudintermedius, both commensal and pathogen

2018 ◽  
Vol 74 (1) ◽  
pp. 6042-2018
Author(s):  
Dorota Chrobak-Chmiel ◽  
Anna Golke ◽  
Kourou Dembele ◽  
Katarzyna Ćwiek ◽  
Magdalena Kizerwetter-Świda ◽  
...  
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Immune System ◽  
Virulence Factors ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Staphylococcus Pseudintermedius ◽  
Underlying Condition ◽  
Secondary Infections ◽  
Pathogenic Effects

Staphylococcus pseudintermedius is considered to be a both commensal and opportunistic canine pathogen. The anal, perineal and nasal locations appear to be the main S. pseudintermedius colonization sites, from which bacteria are transmitted to other body sites, causing secondary infections. When the immune system is compromised because of an underlying condition, the skin becomes susceptible to infection. Thus, the host’s condition seems to play a crucial role in the pathogenesis of S. pseudintermedius infections. There are some predisposing factors, one of which is atopic dermatitis. The pathogenic effects of S. pseudintermedius are mediated by several virulence factors, for instance superantigens, which play an important role by causing dermatitis. The immune system has evolved many different mechanisms to recognize and deal with pathogens, but bacteria have also developed various strategies to evade them. In this review, we focus on early stages of the innate immune response with particular emphasis on the mechanisms of recognition of staphylococci and the action of antimicrobial peptides. .

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