scholarly journals Potentials of probiotics in the treatment of food allergy – a review

2014 ◽  
Vol 32 (No. 3) ◽  
pp. 205-212 ◽  
Author(s):  
A. Patel ◽  
N. Shah
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Food Allergy ◽  
Immune System ◽  
Current Paper ◽  
Gastrointestinal Disorders ◽  
Recent Advances ◽  
Health Promoting ◽  
Treatment Of Food Allergy ◽  
Made In

Food allergy is an adverse immune response to some proteins in some foods. Probiotic, health promoting bacteria have gained much importance because of their innumerable benefits, particularly in the treatment of diarrhea, hypercholesterolemia, atopic dermatitis, eczema, and gastrointestinal disorders by strengthening the immune system. The current paper reviews recent advances made in the treatment of food allergy through employing probiotic or synbiotic therapy. The results of several reports are very promising suggesting probiotics can influence the immune system to curtail the allergic responses.

scholarly journals Immunomodulatory properties of milk

2000 ◽  
Vol 84 (S1) ◽  
pp. 81-89 ◽  
Author(s):  
Martin L. Cross ◽  
H. S. Gill
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Immune Function ◽  
Bovine Milk ◽  
Significant Progress ◽  
Commercial Interest ◽  
Health Promoting ◽  
Experimental Approaches ◽  
Immunomodulatory Properties ◽  
Made In

There is increasing commercial interest in the production of functional foodstuffs which have health-promoting properties. Over the last five to ten years, significant progress has been made in the identification and characterisation of bovine milk components that can affect the function of the immune system. This review outlines the major components of bovine milk that have been shown to modulate immune function, and discusses experimental approaches to the identification of various facets of the immune response that are known to be affected by milk-derived proteins.

scholarly journals Staphylococcus pseudintermedius, both commensal and pathogen

2018 ◽  
Vol 74 (1) ◽  
pp. 6042-2018
Author(s):  
Dorota Chrobak-Chmiel ◽  
Anna Golke ◽  
Kourou Dembele ◽  
Katarzyna Ćwiek ◽  
Magdalena Kizerwetter-Świda ◽  
...  
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Immune System ◽  
Virulence Factors ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Staphylococcus Pseudintermedius ◽  
Underlying Condition ◽  
Secondary Infections ◽  
Pathogenic Effects

Staphylococcus pseudintermedius is considered to be a both commensal and opportunistic canine pathogen. The anal, perineal and nasal locations appear to be the main S. pseudintermedius colonization sites, from which bacteria are transmitted to other body sites, causing secondary infections. When the immune system is compromised because of an underlying condition, the skin becomes susceptible to infection. Thus, the host’s condition seems to play a crucial role in the pathogenesis of S. pseudintermedius infections. There are some predisposing factors, one of which is atopic dermatitis. The pathogenic effects of S. pseudintermedius are mediated by several virulence factors, for instance superantigens, which play an important role by causing dermatitis. The immune system has evolved many different mechanisms to recognize and deal with pathogens, but bacteria have also developed various strategies to evade them. In this review, we focus on early stages of the innate immune response with particular emphasis on the mechanisms of recognition of staphylococci and the action of antimicrobial peptides. .

Recent advances in immunotherapy: the active treatment of food allergy on the horizon

2013 ◽  
Vol 9 (10) ◽  
pp. 891-893 ◽  
Author(s):  
Giovanni B Pajno ◽  
Lucia Caminiti ◽  
Giuseppe Crisafulli ◽  
Giuseppina Salzano
Keyword(s):  
Food Allergy ◽  
Active Treatment ◽  
Recent Advances ◽  
Treatment Of Food Allergy

scholarly journals Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 468
Author(s):  
Antonella Di Sotto ◽  
Annabella Vitalone ◽  
Silvia Di Giacomo
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Clinical Evidence ◽  
The Body ◽  
Immune Disorders ◽  
Pharmacological Treatments ◽  
Abnormal Immune Response ◽  
Health Promoting ◽  
Immune System Modulation ◽  
Immune Defences

Immunomodulators are agents able to affect the immune system, by boosting the immune defences to improve the body reaction against infectious or exogenous injuries, or suppressing the abnormal immune response occurring in immune disorders. Moreover, immunoadjuvants can support immune system acting on nonimmune targets, thus improving the immune response. The modulation of inflammatory pathways and microbiome can also contribute to control the immune function. Some plant-based nutraceuticals have been studied as possible immunomodulating agents due to their multiple and pleiotropic effects. Being usually more tolerable than pharmacological treatments, their adjuvant contribution is approached as a desirable nutraceutical strategy. In the present review, the up to date knowledge about the immunomodulating properties of polysaccharides, fatty acids and labdane diterpenes have been analyzed, in order to give scientific basic and clinical evidence to support their practical use. Since promising evidence in preclinical studies, limited and sometimes confusing results have been highlighted in clinical trials, likely due to low methodological quality and lacking standardization. More investigations of high quality and specificity are required to describe in depth the usefulness of these plant-derived nutraceuticals in the immune system modulation, for health promoting and disease preventing purposes.

scholarly journals Skin Barrier Function and Its Importance at the Start of the Atopic March

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mary Beth Hogan ◽  
Kathy Peele ◽  
Nevin W. Wilson
Keyword(s):  
Clinical Trials ◽  
Atopic Dermatitis ◽  
Food Allergy ◽  
Immune System ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Allergen Sensitization ◽  
Epidermal Barrier ◽  
Atopic March

Atopic dermatitis can be due to a variety of causes from nonatopic triggers to food allergy. Control of egress of water and protection from ingress of irritants and allergens are key components of cutaneous barrier function. Current research suggests that a degraded barrier function of the skin allows the immune system inappropriate access to environmental allergens. Epidermal aeroallergen exposure may allow sensitization to allergen possibly initiating the atopic march. Further research into connections between epidermal barrier function and possible allergen sensitization will be important to undertake. Future clinical trials focused on skin barrier protection may be of value as a possible intervention in prevention of the initiation of the atopic march.

scholarly journals Potential of Sulforaphane as a Natural Immune System Enhancer: A Review

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 752
Author(s):  
Andrea Mahn ◽  
Antonio Castillo
Keyword(s):  
Immune Response ◽  
Clinical Trials ◽  
Immune System ◽  
Target Genes ◽  
Pharmaceutical Products ◽  
Cellular Level ◽  
Promoting Effect ◽  
Activation Of Transcription ◽  
Health Promoting

Brassicaceae are an outstanding source of bioactive compounds such as ascorbic acid, polyphenols, essential minerals, isothiocyanates and their precursors, glucosinolates (GSL). Recently, GSL gained great attention because of the health promoting properties of their hydrolysis products: isothiocyanates. Among them, sulforaphane (SFN) became the most attractive one owing to its remarkable health-promoting properties. SFN may prevent different types of cancer and has the ability to improve hypertensive states, to prevent type 2 diabetes–induced cardiomyopathy, and to protect against gastric ulcer. SFN may also help in schizophrenia treatment, and recently it was proposed that SFN has potential to help those who struggle with obesity. The mechanism underlying the health-promoting effect of SFN relates to its indirect action at cellular level by inducing antioxidant and Phase II detoxifying enzymes through the activation of transcription nuclear factor (erythroid-derived 2)-like (Nrf2). The effect of SFN on immune response is generating scientific interest, because of its bioavailability, which is much higher than other phytochemicals, and its capacity to induce Nrf2 target genes. Clinical trials suggest that sulforaphane produces favorable results in cases where pharmaceutical products fail. This article provides a revision about the relationship between sulforaphane and immune response in different diseases. Special attention is given to clinical trials related with immune system disorders.

scholarly journals Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Jessica M. F. Hall ◽  
desAnges Cruser ◽  
Alan Podawiltz ◽  
Diana I. Mummert ◽  
Harlan Jones ◽  
...  
Keyword(s):  
Immune Response ◽  
Nervous System ◽  
Atopic Dermatitis ◽  
Immune System ◽  
Sympathetic Nervous System ◽  
Psychological Stress ◽  
Hpa Axis ◽  
Skin Diseases ◽  
Treatment Strategies ◽  
Sympathetic Nervous

Psychological stress, an evolutionary adaptation to the fight-or-flight response, triggers a number of physiological responses that can be deleterious under some circumstances. Stress signals activate the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Elements derived from those systems (e.g., cortisol, catecholamines and neuropeptides) can impact the immune system and possible disease states. Skin provides a first line of defense against many environmental insults. A number of investigations have indicated that the skin is especially sensitive to psychological stress, and experimental evidence shows that the cutaneous innate and adaptive immune systems are affected by stressors. For example, psychological stress has been shown to reduce recovery time of the stratum corneum barrier after its removal (innate immunity) and alters antigen presentation by epidermal Langerhans cells (adaptive immunity). Moreover, psychological stress may trigger or exacerbate immune mediated dermatological disorders. Understanding how the activity of the psyche-nervous -immune system axis impinges on skin diseases may facilitate coordinated treatment strategies between dermatologists and psychiatrists. Herein, we will review the roles of the HPA axis and the sympathetic nervous system on the cutaneous immune response. We will selectively highlight how the interplay between psychological stress and the immune system affects atopic dermatitis and psoriasis.

scholarly journals Allergic skin conditions - causes, clinical features and treatment

2018 ◽  
Vol 60 (6) ◽  
pp. 34-37
Author(s):  
Hendrick M. Motswaledi
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Immune System ◽  
Skin Condition ◽  
System Response ◽  
Hand Dermatitis ◽  
Allergic Skin ◽  
Immune System Response ◽  
Skin Conditions ◽  
Allergic Contact

Allergic skin conditions are caused by allergens. When an allergen is responsible for triggering an immune system response, this results in an allergic skin condition. Some of these allergens are physical agents which evoke an immune response by way of contact with the skin and some are food-stuffs and drugs taken systemically.Allergic skin conditions include urticaria and angio-oedema, allergic contact dermatitis, atopic dermatitis, hand dermatitis, photoallergic reactions and phototoxic reactions. These conditions are briefly discussed in this article.

Atopic dermatitis: new horizons of therapy

2019 ◽  
Vol 1 (7) ◽  
pp. 29-32 ◽  
Author(s):  
L. S. Kruglova ◽  
E. M. Gensler
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Targeted Therapy ◽  
Inflammatory Response ◽  
Bronchial Asthma ◽  
New Horizons ◽  
The Past

Over the past decades, the first breakthrough milestone in the treatment of severe forms of atopic dermatitis (AD) has been targeted therapy aimed at inhibiting IL-4 and IL-13. This was made possible thanks to advances in the understanding of the pathogenesis of AD, the driver of which is the Th2-type immune response, which also underlies such manifestations of atopy as bronchial asthma, allergic rhinitis, and polynosis. In the case of the Th2-type immune response, cytokines IL-4 and IL-13 are secreted, which are the main promoters of the inflammatory response in AD. Inhibition of IL-4 and IL-13 leads to the prevention of inflammation and is an effective approach to therapy. The use of therapy aimed at inhibition of cytokines allows you to effectively cope with the manifestations of severe and moderately severe blood pressure.

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