scholarly journals The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy

2010 ◽  
Vol 269 (1) ◽  
pp. 45-53 ◽  
Author(s):  
J. M. Huston ◽  
K. J. Tracey
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Inflammatory Pathway ◽  
Anti Inflammatory

scholarly journals Heart rate variability predicts levels of inflammatory markers: Evidence for the vagal anti-inflammatory pathway

2015 ◽  
Vol 49 ◽  
pp. 94-100 ◽  
Author(s):  
Timothy M. Cooper ◽  
Paula S. McKinley ◽  
Teresa E. Seeman ◽  
Tse-Hwei Choo ◽  
Seonjoo Lee ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Inflammatory Markers ◽  
Inflammatory Pathway ◽  
Anti Inflammatory

scholarly journals Neural signature of cerebral activity of the fetal cholinergic anti‐inflammatory pathway derived from heart rate variability

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Lucien Daniel Durosier ◽  
Alex Xu ◽  
Brad Matushewski ◽  
Mingju Cao ◽  
Christophe Herry ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Inflammatory Pathway ◽  
Cerebral Activity ◽  
Neural Signature ◽  
Anti Inflammatory

scholarly journals Umbilical cord occlusions in near-term ovine fetus induce increased beat-to-beat heart rate variability correlating to decreases in neuroinflammation: a case for the afferent cholinergic anti-inflammatory pathway?

2015 ◽  
Author(s):  
Martin G Frasch ◽  
Mark Szynkaruk ◽  
Andrew P Prout ◽  
Karen Nygard ◽  
Ruud Veldhuizen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Vagus Nerve ◽  
Fetal Brain ◽  
In Utero ◽  
Inflammatory Pathway ◽  
Anti Inflammatory ◽  
Near Term ◽  
Ovine Fetal

Neuroinflammation in utero may contribute to brain injury resulting in life long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) in controlling inflammation has been described in adults, but its importance in the fetus is unknown. Moreover, it is unknown whether CAP may also exert anti-inflammatory effects on the brain via CAP's afferent component of the vagus nerve. Based on multiple clinical studies in adults and our own work in fetal autonomic nervous system, we gauged the degree of CAP activity in vivo using heart rate variability measures reflecting fluctuations in vagus nerve activity. Measuring microglial activation in the ovine fetal brain near-term, we show in vivo that afferent fetal CAP may translate increased vagal cholinergic signaling into suppression of cerebral inflammation in response to near-term hypoxic acidemia as might occur during labour. Our findings suggest a new control mechanism of fetal neuroinflammation via the vagus nerve, providing novel possibilities for its non-invasive monitoring in utero and for targeted treatment.

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