A new core promoter mutation and premature stop codon in the S gene in HBV strains from Iranian patients with cirrhosis

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Key Points B cells but not red cells are GPI deficient in PIGM-associated IGD, caused by a core promoter mutation that abrogates Sp1 binding. In red but not B cells, PIGM transcription is independent of Sp1 binding to the core promoter, hence GPI expression in red cells is near normal.


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