Glycemic control in adolescents with type 1 diabetes mellitus improves lipid serum levels and oxidative stress

Abstract Background Type-1 diabetes mellitus (T1DM) causes endothelial dysfunction and early atherosclerosis, which can result in premature coronary artery disease. The aim of this study was to determine the impact of glycemic control, vascular oxidative stress and inflammation on vascular health in adolescents with T1DM. Methods This was a cross-sectional study in adolescents with age- and sex-matched T1DM who were ≥12 years and were at least 2 years post-diagnosis. Recruitment was balanced to include individuals with hemoglobin A1c (HbA1c) ≤8.5% (n=27) or with HbA1c ≥9.5% (n=25). Biomarkers of inflammation were measured in the blood including C-reactive protein (CRP), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), E-selectin, fibrinogen and tumor necrosis factor-α (TNF-α). Carotid intima media thickness (cIMT) and peripheral arterial tonometry (PAT) were assessed. Results Plasma E-selectin level was significantly different between the two groups with higher levels in the group with HbA1c ≥9.5% (65.0±27.7 ng/mL vs. 48.8±21.5 ng/mL, p=0.02). Though cIMT and PAT were not significantly different between the groups, Pearson correlation showed a significant direct relationship between rising HbA1c and mean right cIMT (p=0.02; r=0.37), PAT (p=0.03, r=0.31) and fibrinogen (p=0.03, r=0.03). Conclusions Elevated E-selectin level is an early marker of oxidative stress in T1DM patients with an elevated HbA1c level. Suboptimal glycemic control as evidenced by a rising HbA1c causes early atherosclerosis.

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Trace elements and oxidative stress in children with type 1 diabetes mellitus

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s157348 ◽

2018 ◽

Vol Volume 11 ◽

pp. 85-92 ◽

Cited By ~ 6

Author(s):

Ashgan A Alghobashy ◽

Usama M Alkholy ◽

Mohamed Talat ◽

Nermin Abdalmonem ◽

Ahmed Zaki ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Trace Elements ◽

Type 1 Diabetes Mellitus ◽

And Oxidative Stress

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Cytokines profile and its correlation with endothelial damage and oxidative stress in patients with type 1 diabetes mellitus and nephropathy

Immunologic Research ◽

10.1007/s12026-016-8806-x ◽

2016 ◽

Vol 64 (4) ◽

pp. 951-960 ◽

Cited By ~ 4

Author(s):

Rodrigo M. C. Pestana ◽

Caroline P. Domingueti ◽

Rita C. F. Duarte ◽

Rodrigo B. Fóscolo ◽

Janice S. Reis ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Endothelial Damage ◽

And Oxidative Stress

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Insulin Suppresses Type 1 Diabetes Mellitus-Induced Ventricular Cardiomyocyte Damage Associated with the Inhibition of Biomarkers of Inflammation and Oxidative Stress in Rats

Pharmacology ◽

10.1159/000500898 ◽

2019 ◽

Vol 104 (3-4) ◽

pp. 157-165 ◽

Cited By ~ 1

Author(s):

Mohammad Dallak ◽

Bahjat Al-Ani ◽

Dina H. Abdel Kader ◽

Refaat A. Eid ◽

Mohamed A. Haidara

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Serum Levels ◽

Left Ventricular ◽

Daily Injection ◽

Necrosis Factor Alpha ◽

Factor Alpha

Aims: We sought to determine whether insulin can protect against type 1 diabetes mellitus (T1DM)-induced cardiac ultrastructural alterations in an animal model of the disease. This has not been investigated before. Methods: Rats were either injected once with 65 mg/kg streptozotocin (STZ) before being sacrificed after 8 weeks or were treated with a daily injection of insulin 2 days by STZ and continued until being sacrificed. Results: Harvested tissues obtained from left ventricles in the untreated T1DM rats showed substantial damage to the cardiomyocyte ultrastructure as demonstrated by disintegrated myofibrils and their sarcomeres, damaged mitochondria and lipid droplets, which was substantially protected by insulin. Insulin also significantly inhibited T1DM-induced hyperglycemia (p < 0.001), dyslipidemia (p < 0.0001), malondialdehyde (MDA; p < 0.0001), tumor necrosis factor-alpha (TNF-α; p < 0.001) and interleukin-6 (p < 0.001). We further demonstrated a significant (p ≤ 0.001) correlation between either sarcomere or mitochondrial injury scoring and the serum levels of glucose, dyslipidemia, and biomarkers of oxidative stress (OxS) and inflammation. Conclusions: These results indicate that insulin effectively suppresses left ventricular cardiomyocyte ultrastructural damage, which substantially slows down the progression of diabetic cardiomyopathy for 8 weeks in a rat model of T1DM, possibly due to the glycemic control and inhibition of dyslipidemia, OxS and inflammation.

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Review: Homocysteine, endothelial dysfunction and oxidative stress in type 1 diabetes mellitus

The British Journal of Diabetes ◽

10.1177/14746514030030050401 ◽

2003 ◽

Vol 3 (5) ◽

pp. 334-340 ◽

Cited By ~ 4

Author(s):

Fiona Wotherspoon ◽

David W Laight ◽

Kenneth M Shaw ◽

Michael H Cummings

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Endothelial Dysfunction ◽

Type 1 Diabetes Mellitus ◽

And Oxidative Stress

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Effect of moderate exercise on renal changes and oxidative stress in ovariectomized rats with type 1 diabetes mellitus

Brazilian Journal of Biological Sciences ◽

10.21472/bjbs.061302 ◽

2019 ◽

Vol 6 (13) ◽

pp. 331-345 ◽

Cited By ~ 2

Author(s):

Mayane Oliveira Rebouças da Silveira ◽

Liliany Souza de Brito Amaral ◽

Samira Itana de Souza ◽

Halanna Rocha Ferraz ◽

Jéssica Alves Dias ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Renal Function ◽

Aerobic Exercise ◽

Type 1 Diabetes Mellitus ◽

Diabetic Rats ◽

Ovariectomized Rats ◽

And Oxidative Stress

This study evaluated the aerobic exercise effects of moderate and progressive intensity on renal function and structure, and oxidative stress in ovariectomized rats with type 1 diabetes mellitus induced by streptozotocin (STZ). Eighteen Wistar rats were divided into 3 groups: OSC - ovariectomized and sedentary control rats; OSD - ovariectomized and sedentary diabetic rats; and OTD - ovariectomized and trained diabetic rats. After induction of diabetes, the OTD group was submitted to eight weeks of exercise. Twenty-four hours after the last training session urine samples were collected. Blood samples and kidneys were collected after euthanasia for renal function analysis, histology, morphometry and oxidative stress. Our results have shown a reduction of the weight gain, increase of kidney weight and postprandial glycemia in diabetic rats. However, exercise decreased glycosuria and prevented the proteinuria in OTD group rats. Focal segmental glomerulosclerosis (FSGS), juxtamedullary glomerular tuft area, tubulointerstitial lesions (TIL), brush border loss and tubular cell debridement were reduced in OTD rats. In addition, exercise training decreased urinary and plasma concentrations of thiobarbituric acid reactive substance (TBARS). Our results demonstrate the beneficial effect of progressive aerobic exercise on proteinuria, glycosuria, and renal structure in ovariectomized diabetic rats, which may be mediated in part by reduction of oxidative stress.

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