Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus

BackgroundSclerostin is an osteocyte-derived inhibitor of the Wnt/β-catenin signaling pathway, which acts as a negative regulator of bone formation. Published data on sclerostin levels in type 1 diabetes mellitus (T1DM) are few.ObjectiveTo evaluate gender differences in sclerostin serum levels and the association among sclerostin, bone mass, bone metabolism, and the main clinical characteristics of subjects with T1DM.Design and methodsA total of 69 patients with T1DM (mean age, 33.7±8.1; 49% males) were enrolled in this cross-sectional study in a clinical research center. Bone mineral density was measured by phalangeal quantitative ultrasound (QUS); bone turnover markers (urinary pyridinoline, deoxypyridinoline (D-PYR), and urine hydroxyproline (OH-PRO) to evaluate bone resorption; serum bone alkaline phosphatase and BGP to evaluate bone formation) and sclerostin were assessed.ResultsD-PYR and sclerostin were significantly higher in women when compared with men (P=0.04). A disease duration >15 years was associated with higher sclerostin levels (P=0.03). Bone turnover markers and QUS parameters were not correlated with sclerostin. A significant negative correlation was observed among QUS parameters, BMI, and OH-PRO. Sclerostin serum levels were correlated with homocysteine (r=−0.34, P=0.005) and vitamin B12 (r=−0.31, P=0.02). Generalized linear model showed that macroangiopathy was the only predictor of sclerostin serum levels (β=−11.8, 95% CI from −21.9 to −1.7; P=0.02).ConclusionsOur data demonstrate that women with T1DM exhibit higher sclerostin levels than men and that circulating sclerostin is not associated with bone turnover markers and phalangeal QUS measurements. Macroangiopathy was associated with sclerostin levels.

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Review: Homocysteine, endothelial dysfunction and oxidative stress in type 1 diabetes mellitus

The British Journal of Diabetes ◽

10.1177/14746514030030050401 ◽

2003 ◽

Vol 3 (5) ◽

pp. 334-340 ◽

Cited By ~ 4

Author(s):

Fiona Wotherspoon ◽

David W Laight ◽

Kenneth M Shaw ◽

Michael H Cummings

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Endothelial Dysfunction ◽

Type 1 Diabetes Mellitus ◽

And Oxidative Stress

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Effect of moderate exercise on renal changes and oxidative stress in ovariectomized rats with type 1 diabetes mellitus

Brazilian Journal of Biological Sciences ◽

10.21472/bjbs.061302 ◽

2019 ◽

Vol 6 (13) ◽

pp. 331-345 ◽

Cited By ~ 2

Author(s):

Mayane Oliveira Rebouças da Silveira ◽

Liliany Souza de Brito Amaral ◽

Samira Itana de Souza ◽

Halanna Rocha Ferraz ◽

Jéssica Alves Dias ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Renal Function ◽

Aerobic Exercise ◽

Type 1 Diabetes Mellitus ◽

Diabetic Rats ◽

Ovariectomized Rats ◽

And Oxidative Stress

This study evaluated the aerobic exercise effects of moderate and progressive intensity on renal function and structure, and oxidative stress in ovariectomized rats with type 1 diabetes mellitus induced by streptozotocin (STZ). Eighteen Wistar rats were divided into 3 groups: OSC - ovariectomized and sedentary control rats; OSD - ovariectomized and sedentary diabetic rats; and OTD - ovariectomized and trained diabetic rats. After induction of diabetes, the OTD group was submitted to eight weeks of exercise. Twenty-four hours after the last training session urine samples were collected. Blood samples and kidneys were collected after euthanasia for renal function analysis, histology, morphometry and oxidative stress. Our results have shown a reduction of the weight gain, increase of kidney weight and postprandial glycemia in diabetic rats. However, exercise decreased glycosuria and prevented the proteinuria in OTD group rats. Focal segmental glomerulosclerosis (FSGS), juxtamedullary glomerular tuft area, tubulointerstitial lesions (TIL), brush border loss and tubular cell debridement were reduced in OTD rats. In addition, exercise training decreased urinary and plasma concentrations of thiobarbituric acid reactive substance (TBARS). Our results demonstrate the beneficial effect of progressive aerobic exercise on proteinuria, glycosuria, and renal structure in ovariectomized diabetic rats, which may be mediated in part by reduction of oxidative stress.

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