Simultaneous effusive and explosive cinder cone eruptions at Veniaminof Volcano, Alaska

Historical eruptions of Veniaminof Volcano, Alaska have all occurred at a 300-m-high cinder cone within the icefilled caldera that characterizes the volcano. At least six of nineteen historical eruptions involved simultaneous explosive and effusive activity from separate vents. Eruptions in 1944, 1983–1984, 1993–1994, 2013, 2018 and 2021 included periods of explosive ash-producing Strombolian activity from summit vents and simultaneous nonexplosive effusion of lava from flank vents on either the southern or northeast sides of the cone. A T-junction conduit network is proposed to explain the simultaneous eruptive styles and as a mechanism for gas-magma segregation that must occur to produce the observed activity. Historical eruptions with simultaneous summit and flank activity produced slightly higher rising ash clouds compared to historical eruptions where simultaneous activity did not occur. This could be a consequence of the partitioning of more gas-charged magma into the vertical conduit of a T-junction conduit system.

Two classes of functional connectivity in dynamical processes in networks

The relationship between network structure and dynamics is one of the most extensively investigated problems in the theory of complex systems of recent years. Understanding this relationship is of relevance to a range of disciplines—from neuroscience to geomorphology. A major strategy of investigating this relationship is the quantitative comparison of a representation of network architecture (structural connectivity, SC) with a (network) representation of the dynamics (functional connectivity, FC). Here, we show that one can distinguish two classes of functional connectivity—one based on simultaneous activity (co-activity) of nodes, the other based on sequential activity of nodes. We delineate these two classes in different categories of dynamical processes—excitations, regular and chaotic oscillators—and provide examples for SC/FC correlations of both classes in each of these models. We expand the theoretical view of the SC/FC relationships, with conceptual instances of the SC and the two classes of FC for various application scenarios in geomorphology, ecology, systems biology, neuroscience and socio-ecological systems. Seeing the organisation of dynamical processes in a network either as governed by co-activity or by sequential activity allows us to bring some order in the myriad of observations relating structure and function of complex networks.

Electron–positron pair plasma in TXS 0506+056 and the ‘neutrino flare’ in 2014–2015

ABSTRACT The detection of a prolonged flaring activity from blazar TXS 0506+056 in temporal and spatial coincidence with the energetic neutrino IceCube-170922A provided evidence about the photohadronic interactions in this source. However, analysis of the archival neutrino and multiwavelength data from the direction of this blazar between 2014 September and 2015 March revealed a ‘neutrino flare’ without observing quasi-simultaneous activity in the gamma-ray bands, posing challenges to established models. Electron–positron (e±) pairs generated from the accretion discs have been amply proposed as a mechanism of bulk acceleration of sub-relativistic and relativistic jets. These pairs annihilate inside the source producing a line around the electron mass, which is blueshifted in the observed frame (on Earth) and redshifted in the frame of the dissipation region of the jet. The redshifted photons in the dissipation region interact with accelerated protons, producing high-energy neutrinos that contribute significantly to the diffuse neutrino flux in the ∼10–20 TeV energy range in connection with gamma-rays from the photopion process, which can be detected by future MeV orbiting satellites. Based on this phenomenological model, we can explain the ‘neutrino flare’ reported in 2014–1015.

Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

Cannabinoid CB2 receptor (CB2) agonists are potential analgesics void of psychotropic effects. Peripheral immune cells, neurons and glia express CB2; however, the involvement of CB2 from these cells in neuropathic pain remains unresolved. We explored spontaneous neuropathic pain through on-demand self-administration of the selective CB2 agonist JWH133 in wild-type and knockout mice lacking CB2 in neurons, monocytes or constitutively. Operant self-administration reflected drug-taking to alleviate spontaneous pain, nociceptive and affective manifestations. While constitutive deletion of CB2 disrupted JWH133-taking behavior, this behavior was not modified in monocyte-specific CB2 knockouts and was increased in mice defective in neuronal CB2 knockouts suggestive of increased spontaneous pain. Interestingly, CB2-positive lymphocytes infiltrated the injured nerve and possible CB2transfer from immune cells to neurons was found. Lymphocyte CB2depletion also exacerbated JWH133 self-administration and inhibited antinociception. This work identifies a simultaneous activity of neuronal and lymphoid CB2that protects against spontaneous and evoked neuropathic pain.

Mesoscale brain dynamics reorganizes and stabilizes during learning

Adaptive behavior is coordinated by neuronal networks that are distributed across multiple brain regions. How cross-regional interactions reorganize during learning remains elusive. We applied multi-fiber photometry to chronically record simultaneous activity of 12-48 mouse brain regions while mice learned a tactile discrimination task. We found that with learning most regions shifted their peak activity from reward-related action to the reward-predicting stimulus. We corroborated this finding by functional connectivity estimation using transfer entropy, which revealed growth and stabilization of mesoscale networks encompassing basal ganglia, thalamus, cortex, and hippocampus, especially during stimulus presentation. The internal globus pallidus, ventromedial thalamus, and several regions in frontal cortex emerged as hub regions. Our results highlight the cooperative action of distributed brain regions to establish goal-oriented mesoscale network dynamics during learning.

Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

Cannabinoid CB2 receptor (CB2r) agonists are potential painkillers void of psychotropic effects. Peripheral immune cells, neurons and glia express CB2r, however the involvement of CB2r from these cells in neuropathic pain remains unresolved. We explored spontaneous neuropathic pain through on-demand self-administration of the selective CB2r agonist JWH133 in wild-type and knockout mice lacking CB2r in neurons, monocytes or constitutively. Operant self-administration reflected drug-taking to alleviate spontaneous pain, nociceptive and affective manifestations. While constitutive deletion of CB2r disrupted JWH133-taking behavior, this behavior was not modified in monocyte-specific CB2r knockouts and was increased in mice defective in neuronal CB2r knockouts suggestive of increased spontaneous pain. Interestingly, CB2r-positive lymphocytes infiltrated the injured nerve and possible CB2r transfer from immune cells to neurons was found. Lymphocyte CB2r depletion also exacerbated JWH133 self-administration and inhibited antinociception. This work identifies a simultaneous activity of neuronal and lymphoid CB2r that protects against spontaneous and evoked neuropathic pain.

Lactoferrin and oral pathologies: a therapeutic treatment

The oral cavity is a non-uniform, extraordinary environment characterized by mucosal, epithelial, abiotic surfaces and secretions as saliva. Aerobic and anaerobic commensal and pathogenic microorganisms colonize the tongue, teeth, jowl, gingiva, and periodontium. Commensals exert an important role in host defenses, while pathogenic microorganisms can nullify this protective function causing oral and systemic diseases. Every day, 750–1000 mL of saliva, containing several host defense constituents including lactoferrin (Lf), are secreted and swallowed. Lf is a multifunctional iron-chelating cationic glycoprotein of innate immunity. Depending on, or regardless of its iron-binding ability, Lf exerts bacteriostatic, bactericidal, antibiofilm, antioxidant, antiadhesive, anti-invasive, and anti-inflammatory activities. Here, we report the protective role of Lf in different oral pathologies, such as xerostomia, halitosis, alveolar or maxillary bone damage, gingivitis, periodontitis, and black stain. Unlike antibiotic therapy, which is ineffective against bacteria that are within a biofilm, adherent, or intracellular, the topical administration of Lf, through its simultaneous activity against microbial replication, biofilms, adhesion, and invasiveness, as well as inflammation, has been proven to be efficient in the treatment of all known oral pathologies without any adverse effects.

Niewspółczesność. O możliwej historii literatury polskiej po 1989 roku

Noncontemporaneity. On the Possible History of Polish Literature after 1989 Temporal and historical frames usually applied to the description of recent Polish literature gradually lose their potential. “Postmodernism,” “late modernism,” and other terms do not reveal the complicated and local temporal landscape of this literature. Processes like the traumatic return of past events (WWII, the Holocaust, Stalinist terror), the simultaneous activity of Polish language writers in countries around the world, immigrant writings, etc., preclude the use of the term “contemporaneity,” since they do not create any shared temporal horizon and belong to processes of different temporal dynamics with separate time rhythms. Rather, they belong to the dimension of “noncontemporaneity” or “asynchrony.” “Noncontemporaneity” is both the general perspective of the latest literature and the experience of the main characters presented by the literary works.

Profil Electroencephalogram (EEG) Pasien Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya Periode Januari 2018 sampai Desember 2018

<p><strong>ABSTRAK</strong></p><p><strong>Pendahuluan:</strong> Elektroensefalogram atau rekam kelistrikkan otak adalah metode dalam neurofisiologi yang telah terbukti dapat diaplikasikan dalam ilmu kedokteran. Berbagai tipe dari ritme otak yang simultan menunjukkan bahwa aktivitas dari neuron korteks otak bergantung pada kondisi status mental seseorang. <strong>Tujuan: </strong>untuk mengetahui pola gelombang EEG pasien di RSAL dr. Ramelan Surabaya. <strong>Metode:</strong> Penelitian ini merupakan penelitian deskriptif dengan metode studi prevalensi. Teknik pengambilan sampling adalah <em>Total Population </em>yaitu semua pasien yang melakukan pemeriksaan EEG yang didapat dari rekam medik ruang EEG RSAL dr. Ramelan Surabaya periode Januari 2018 sampai Desember 2018 yang memenuhi kriteria inklusi dan eksklusi dari sampel. <strong>Hasil:</strong> Pasien yang paling sering melakukan pemeriksaan berdasarkan usia adalah usia balita, berdasarkan jenis kelamin adalah laki-laki, dan berdasarkan diagnosa klinis adalah konvulsif epilepsy dengan pola gelombang tersering yaitu SW.</p><p><strong>Kata kunci:</strong> elektroensefalogram, kelistrikkan otak, epilepsi.</p><p><strong>ABSTRACT</strong></p><p><strong>Introduction:</strong> An electroencephalogram (EEG) is an accepted method in neurophysiology with a wide application. Different types of brain rhythms indicate that simultaneous activity of the brain cortex neurons depend on the person’s mental state<span style="font-family: Calibri; font-size: medium;">.</span> <strong>Aim:</strong> to know the EEG pattern of patients at dr. Ramelan Naval Hospital Surabaya. <strong>Method:</strong> this research is a descriptive research with prevalence study method. Using total population for sampling, all patients who did the electroencephalogram examination at dr. Ramelan Naval Hospital Surabaya period January 2018 until December 2018. <strong>Result:</strong> Toddlers were the most frequently patients who did electroencephalogram examination. Based on sex, male were the most frequent. Based on clinical diagnose, patient with convulsive epilepsy are the most frequent with SW wave result.</p><p><strong>Keywords:</strong> electroencephalogram, brain activity, epilepsy.</p>