scholarly journals Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts

2011 ◽  
Vol 24 (8) ◽  
pp. 856-864 ◽  
Author(s):  
Lei Tian ◽  
Jie Gao ◽  
Guangbin Weng ◽  
Huimin Yi ◽  
Bole Tian ◽  
...  
Keyword(s):  
Beta Cell ◽  
Human Islet ◽  
Cell Replication ◽  
Beta Cell Replication

Growth factors and beta cell replication

2006 ◽  
Vol 38 (5-6) ◽  
pp. 931-950 ◽  
Author(s):  
Rupangi C. Vasavada ◽  
Jose A. Gonzalez-Pertusa ◽  
Yuichi Fujinaka ◽  
Nathalie Fiaschi-Taesch ◽  
Irene Cozar-Castellano ◽  
...  
Keyword(s):  
Growth Factors ◽  
Beta Cell ◽  
Cell Replication ◽  
Beta Cell Replication

scholarly journals Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Rebeca Fernandez-Ruiz ◽  
Ainhoa García-Alamán ◽  
Yaiza Esteban ◽  
Joan Mir-Coll ◽  
Berta Serra-Navarro ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Beta Cell Proliferation ◽  
Cell Replication ◽  
Trophic Effect ◽  
Beta Cell Replication

AbstractExpanding the mass of pancreatic insulin-producing beta cells through re-activation of beta cell replication has been proposed as a therapy to prevent or delay the appearance of diabetes. Pancreatic beta cells exhibit an age-dependent decrease in their proliferative activity, partly related to changes in the systemic environment. Here we report the identification of CCN4/Wisp1 as a circulating factor more abundant in pre-weaning than in adult mice. We show that Wisp1 promotes endogenous and transplanted adult beta cell proliferation in vivo. We validate these findings using isolated mouse and human islets and find that the beta cell trophic effect of Wisp1 is dependent on Akt signaling. In summary, our study reveals the role of Wisp1 as an inducer of beta cell replication, supporting the idea that the use of young blood factors may be a useful strategy to expand adult beta cell mass.

scholarly journals IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice

Diabetologia ◽  
2008 ◽  
Vol 51 (10) ◽  
pp. 1862-1872 ◽  
Author(s):  
J. Agudo ◽  
E. Ayuso ◽  
V. Jimenez ◽  
A. Salavert ◽  
A. Casellas ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Beta Cell ◽  
Endocrine Pancreas ◽  
Cell Replication ◽  
Cell Cycle Protein ◽  
Beta Cell Replication ◽  
Igf I

scholarly journals A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

2015 ◽  
Vol 21 (4) ◽  
pp. 383-388 ◽  
Author(s):  
Peng Wang ◽  
Juan-Carlos Alvarez-Perez ◽  
Dan P Felsenfeld ◽  
Hongtao Liu ◽  
Sharmila Sivendran ◽  
...  
Keyword(s):  
Beta Cell ◽  
High Throughput ◽  
Pancreatic Beta Cell ◽  
Cell Replication ◽  
Beta Cell Replication ◽  
Chemical Screen

Stimulating Beta Cell Replication and Improving Islet Graft Function by a GPR40 and GPR120 Dual Agonist

2012 ◽  
Vol 94 (10S) ◽  
pp. 567
Author(s):  
J. Gao ◽  
G. Weng ◽  
A. Aasarullah ◽  
Y. Lu ◽  
M. Holstein ◽  
...  
Keyword(s):  
Beta Cell ◽  
Graft Function ◽  
Islet Graft ◽  
Cell Replication ◽  
Beta Cell Replication ◽  
Dual Agonist
Sign in / Sign up

Export Citation Format

Share Document