Characteristics of immunoglobulin A nephropathy with mesangial immunoglobulin G and immunoglobulin M deposition

Nephrology ◽  
2010 ◽  
Vol 15 (8) ◽  
pp. 747-754 ◽  
Author(s):  
TAKAHITO MORIYAMA ◽  
ARI SHIMIZU ◽  
TAKASHI TAKEI ◽  
KEIKO UCHIDA ◽  
KAZUHO HONDA ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Immunoglobulin A ◽  
Immunoglobulin M ◽  
Immunoglobulin A Nephropathy

Clinicopathological characteristics of primary immunoglobulin A nephropathy with immunoglobulin M deposition

2021 ◽  
Author(s):  
Han Ouyang ◽  
Jian Wen ◽  
Kai Song ◽  
Huaying Shen
Keyword(s):  
Immunoglobulin A ◽  
Clinicopathological Characteristics ◽  
Immunoglobulin M ◽  
Endothelial Cell Proliferation ◽  
Negative Group ◽  
Immunoglobulin A Nephropathy ◽  
Positive Group ◽  
Renal Tubular ◽  
The Relationship ◽  
Ig G

IntroductionImmunoglobulin (Ig) G deposition in patients with IgA nephro­pathy (IgAN) often indicates poor prognosis, but the relationship between IgM deposition and the clinicopathology of IgAN remains controversial. The purpose of this study is to further understand the relationship between IgM deposition and IgAN, so as to provide a basis for clinical evaluation and treatment.Material and methodsWe included a total of 839 IgAN patients from the nephropathy departments of 2 hospitals; there were 162 IgM-positive patients and 677 IgM-negative patients. Clinical and pathological data were retrospectively analysed. In addition, a multifaceted comparison was made between the IgM-positive group and the IgM-negative group.ResultsThe serum albumin and IgG levels of the IgM-positive group were lower than those of the IgM-negative group, and the levels of low-density lipo­protein, 24 h proteinuria, and IgM were higher than those of the IgM-nega­tive group. The proportion of endothelial cell proliferation (E1), segmental sclerosis or adhesion (S1), and renal tubular interstitial score in the IgM-posi­tive group were all higher than those in the IgM-negative group. Immunofluo­rescence results showed that the proportion of IgM-positive combination and IgG and C1q deposition was higher than that in the IgM-negative group.ConclusionsImmunoglobulin A nephropathy patients with IgM deposition have relatively poor clinical biochemical indicators, and the degree of renal pathological damage is also relatively serious.

Major Immunoglobulin Ratios in Carcinoma of the Head and Neck

1978 ◽  
Vol 87 (3) ◽  
pp. 412-415 ◽  
Author(s):  
Arnold E. Katz ◽  
John O. Nysather ◽  
Lee A. Harker
Keyword(s):  
Head And Neck ◽  
Immunoglobulin G ◽  
Immunoglobulin A ◽  
Elevated Serum ◽  
Immunoglobulin M ◽  
Serum Immunoglobulin ◽  
Control Groups ◽  
Immunoglobulin Production ◽  
Patients With Cancer ◽  
Serum Iga

— Serum immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) levels were determined on 245 patients with carcinoma of the head and neck and on 92 controls. Ratios of these levels were calculated for each subject. The patients with cancer demonstrated elevated serum IgA levels ( P <.0001) and elevated IgA/IgM and IgA/IgG ratios ( P <.05). No differences were noted when the IgM/IgG ratios were compared between the cancer and the control groups. These observations are offered as evidence that previously reported elevations of serum IgA levels in patients with carcinoma of the head and neck are not merely an index of nonspecific increased immunoglobulin production in these patients.

scholarly journals Multi-Micronutrient Supplementation and Immunoglobulin Response in Well-Fed Firefighters

2020 ◽  
Vol 05 (01) ◽  
pp. E1-E7
Author(s):  
José Augusto Rodrigues Santos ◽  
Ricardo J. Fernandes ◽  
Rodrigo Zacca
Keyword(s):  
Immunoglobulin G ◽  
Physical Training ◽  
Immunoglobulin A ◽  
Immunoglobulin M ◽  
Control Group ◽  
Micronutrient Supplementation ◽  
Mean Values ◽  
Serum Immunoglobulins ◽  
Recruit Training ◽  
And Control

AbstractIntensive physical training programs can affect the immune system. This study aims to verify the multi-micronutrient supplementation effects on serum immunoglobulins levels prior to and after a five-week physical training program. Twenty-four male recruit firefighters were randomly allocated into supplemented (with Prisfar Ever-Fit Plus over 35 consecutive days) and placebo groups (n=12 each). Serum immunoglobulins G, A, and M were assessed. Supplementation effect was detected for immunoglobulin G (eta-squared, η2: 0.09; p=0.035; power: 0.56), A (η2: 0.24; p=0.001; power: 0.95), and M (η2: 0.09; p=0.036; power: 0.56). Although immunoglobulin A was different between groups at baseline (mean difference: 42.58; 95%CI: 7.00 to 78.16 mg/dL; p=0.021; d=2.48), within-group (before vs. after five weeks) showed no differences for both supplemented and control groups. In addition, even if immunoglobulin G and M were similar at baseline, immunoglobulin G decreased (mean diff.: 46.4; 95%CI: 6.7 to 86.1 mg/dL; p=0.03; d=0.74) and immunoglobulin M increased (mean diff.: −10.7; 95%CI: −15.8 to −5.5 mg/dL; p=0.001; d=−1.33) in the control group. Although mean values remained within the reference values, changes observed for immunoglobulin G and M may reflect some immune protection for firefighters engaged in recruit training.

scholarly journals Immunoglobulin G antibodies to the N-Methyl-D-aspartate receptor are distinct from immunoglobulin A and immunoglobulin M responses

2014 ◽  
Vol 77 (1) ◽  
pp. 183-183 ◽  
Author(s):  
Eric Lancaster ◽  
Frank Leypoldt ◽  
Maarten J. Titulaer ◽  
Jérôme Honnorat ◽  
Patrick J. Waters ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Immunoglobulin A ◽  
Immunoglobulin M ◽  
Aspartate Receptor
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