Fluorescence-guided transurethral resection of bladder tumours reduces bladder tumour recurrence due to less residual tumour tissue in T  a/T1 patients: a randomized two-centre study

2011 ◽  
Vol 108 (8b) ◽  
pp. E297-E303 ◽  
Author(s):  
Gregers G. Hermann ◽  
Karin Mogensen ◽  
Steen Carlsson ◽  
Niels Marcussen ◽  
Susanne Duun
Author(s):  
Kishan K. Raj ◽  
Yogesh Taneja ◽  
Prateek Ramdev ◽  
Santosh K. Dhaked ◽  
Charan K. Singh ◽  
...  

Background: Transurethral resection of bladder tumour (TURBT) is the primary treatment modality for Non-muscle invasive bladder cancer (NMIBC). Restaging transurethral resection of bladder tumour (RETURBT) is indicated to reduce risk of residual disease and correct staging errors after primary TURBT. The aim of the study is to evaluate the risk of residual tumour and upstaging in NMIBC after TURBT and to investigate the risk factors for the same.Methods: A prospective observational study was carried out over 4 years and 87 patients were included in the study. Patients with NMIBC underwent RETURBT after 2-6 weeks of primary TURBT. The incidence of residual tumour and upstaging in RETUBRT was correlated with various histopathological and morphological parameters in primary TURBT.Results: Out of 87 patients, who underwent RETURBT, residual disease was present in 51 patients (58.6%) and upstaging occurred in 22 patients (25.2%).On univariate analysis, T1 stage (p=0.01), high grade (p=0.01), Carcinoma in situ(CIS) (p=0.01) and multifocality (p=0.05) were predictive for residual disease in RETURBT. High grade (p=0.01), CIS (p=0.01) and absence of detrusor muscle in specimen (p=0.03) were risk factors for upstaging in RETURBT.Conclusions: NMIBC have high incidence of residual disease and upstaging after primary TURBT. T1 stage, high tumour grade, CIS, and multifocality are risk factors for residual disease after primary TURBT. High tumour grade, CIS and absence of detrusor muscle are strongly associated with upstaging during RETURBT.


1988 ◽  
Vol 16 (3) ◽  
pp. 324-328 ◽  
Author(s):  
T. Harioka ◽  
M. Murakawa ◽  
J. Noda ◽  
K. Mori

The effects of a continuously warmed irrigating solution on body temperature during transurethral resection of the prostate and of bladder tumours were studied in forty patients. Anaesthesia was spinal and deep body temperatures of the forehead and lower abdomen were measured, using a deep body thermometry system. Both forehead and lower abdominal deep body temperatures decreased significantly in the patients who underwent transurethral resection of the prostate with an irrigating solution at operating room temperature, but did not decrease in the patients who received a continuously warmed irrigating solution. The same results were obtained for the patients who underwent transurethral resection of bladder tumour. Our results indicate that a continuously warmed irrigating solution could prevent the fall in body temperature during transurethral resection, especially prostate resection, under spinal anaesthesia.


1991 ◽  
Vol 82 (9) ◽  
pp. 1430-1435
Author(s):  
Atsushi Iguchi ◽  
Hidetoshi Yoshinaga ◽  
Zenjiro Masaki ◽  
Hisayuki Tsugitomi ◽  
Kazuo Wakayama

1992 ◽  
Vol 59 (1_suppl) ◽  
pp. 127-129
Author(s):  
T. Zenico ◽  
M. Zoli ◽  
F. Fabbri ◽  
C. Camporesi ◽  
G. Maltoni

The relapse of superficial bladder tumours can be prevented, after endoscopic treatment, by intravesical chemo and immunoprophylaxis. In the first 6 months of 1991, 14 patients (13 males, 1 female, average age 58.3) were treated endoscopically for superficial bladder tumours, which had been detected on average 3.5 years earlier. Intravesical treatment was with 50 mg Epirubicin and, after 3 hours, alpha-2b Interferon once a week for 8 weeks. The patients had a hematological and cystoscopic control every 3 months for one year. A decrease in tumour recurrence was noted at the first endoscopic control, then only slow growth of superficial bladder tumour recurrence was observed.


2013 ◽  
Vol 7 (11-12) ◽  
pp. 812
Author(s):  
Aihua Li ◽  
Feng Zhang ◽  
Wei Fang ◽  
Weiwu Li ◽  
Honghai Lu ◽  
...  

Introduction: We evaluate the efficacy and safety of transurethral resection and degeneration of bladder tumour (TURD-Bt).Methods: In total, 56 patients with bladder tumour were treated by TURD-Bt. The results in these patients were compared with 32 patients treated by current transurethral resection of bladder tumour (TUR-Bt). Patients with or without disease progressive factors were respectively compared between the 2 groups. The factors included recurrent tumour, multiple tumours, tumour ≥3 cm in diameter, clinical stage T2, histological grade 3, adenocarcinoma, and ureteral obstruction or hydronephrosis.Results: Follow-up time was 48.55 ± 23.74 months in TURD-Bt group and 56.28 ± 17.61 months in the TUR-Bt group (p > 0.05). In patients without progressive factors, no tumour recurrence was found and overall survival was 14 (100%) in the TURD-Bt group; 3 (37.50%) patients had recurrence and overall survival was 5 (62.5%) in the TUR-Bt group. In patients with progressive factors, 8 (19.05%) patients had tumour recurrence, overall survival was 32 (76.19%) and cancer death was 3 (7.14%) in TURD-Bt group; 18 (75.00%) patients had tumour recurrence (p < 0.05), overall survival was 12 (50.00%) (p < 0.01) and cancer death was 8 (33.33%) (p < 0.05) in TUR-Bt group. No significant complication was found in TURD-Bt group.Conclusion: This study suggests that complete resection and degeneration of bladder tumour can be expected by TURD-Bt. The surgical procedure is safe and efficacious, and could be predictable and controllable before and during surgery. We would conclude that for bladder cancers without lymph node metastasis and distal metastasis, TURD-Bt could be performed to replace radical TUR-Bt and preserve the bladder.


2017 ◽  
Vol 11 (5) ◽  
pp. 203 ◽  
Author(s):  
Matthew Truong ◽  
Lorraine Liang ◽  
Janet Kukreja ◽  
Jeanne O’Brien ◽  
Jerome Jean-Gilles ◽  
...  

Introduction: We sought to determine how frequently cautery (thermal) artifact precludes an accurate determination of stage at initial transurethral resection of bladder tumour (TURBT) of large bladder tumours.Methods: We queried our institution’s billing data to identify patients who underwent TURBT for large bladder tumours >5cm (CPT 52240) by two urologists at an academic centre from January 2009 through April 2013. Only patients who underwent initialstaging TURBT for urothelial cancer were included. Pathological reports were reviewed for stage, number of separate pathological specimens per TURBT, and presence of cautery artifact. Operative reports were reviewed for whether additional cold cup biopsies were taken of other suspicious areas of the bladder, resident involvement, and type of electrocautery.Results: We identified 119 patients who underwent initial staging TURBT for large tumours. Cautery artifact interfered with accurate staging in 7/119 (6%) of cases. Of these, six patients underwent restaging TURBT, with 50% percent experiencing upstaging to T2 disease. Tumour size, tumour grade, whether additional cold cup biopsies were taken, number of separate pathological specimens sent, and resident involvement were not associated with cautery artifact (all p>0.05). Bipolar resection had a higher rate of cautery artifact 5/42 (12%), compared to monopolar resection 2/77 (2.6%) approaching significance (p=0.095).Conclusions: Cautery artifact may delay accurate staging at initial TURBT for large tumours by understaging up to 6% of patients.


2013 ◽  
Vol 7 (1-2) ◽  
pp. 130 ◽  
Author(s):  
Sun Gook Ahn ◽  
Hoon Jang ◽  
Dong Seok Han ◽  
Jung Uee Lee ◽  
Seung Mo Yuk

Pheochromocytoma of the urinary bladder is rare. We have experienced a case of unexpected pheochromocytoma of the urinary bladder in a 45-year-old female. An ultrasonographic, computed tomography scan and cystoscopic examination showed a submucosal bladder mass. After transurethral resection of bladder tumour was performed, the bladder mass was confirmed as pheochromocytomaby a pathologist. After surgery, the patient underwent a subsequent pelvic magnetic resonance imaging, positron emission tomography and I131-methyliodobenzylguanidine (I131-MIBG). An image study showed no residual tumour sites and no lymphaticmetastasis. The patient has had no tumour recurrence and no voiding symptoms 3 years after the surgery.


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