The role of interleukin-6 in insulin resistance, body fat distribution and energy balance

2007 ◽  
Vol 0 (0) ◽  
pp. 071024234852001-??? ◽  
Author(s):  
M. Hoene ◽  
C. Weigert
Keyword(s):  
Insulin Resistance ◽  
Energy Balance ◽  
Body Fat ◽  
Interleukin 6 ◽  
Fat Distribution ◽  
Body Fat Distribution

scholarly journals Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity

Diabetes ◽  
2014 ◽  
Vol 63 (12) ◽  
pp. 4378-4387 ◽  
Author(s):  
R. A. Scott ◽  
T. Fall ◽  
D. Pasko ◽  
A. Barker ◽  
S. J. Sharp ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Body Fat ◽  
Genetic Variants ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Common Genetic Variants

scholarly journals Pioglitazone improves insulin resistance and decreases blood pressure in adult patients with congenital adrenal hyperplasia

2009 ◽  
Vol 161 (6) ◽  
pp. 887-894 ◽  
Author(s):  
Jeanne Margot Kroese ◽  
Christiaan F Mooij ◽  
Marinette van der Graaf ◽  
Ad R M M Hermus ◽  
Cees J Tack
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Body Fat ◽  
Matched Control ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Adrenal Hyperplasia ◽  
Insulin Resistant ◽  
Steroid Profiles

ContextPatients with congenital adrenal hyperplasia (CAH) are chronically treated with supraphysiological doses of glucocorticoids, which are known to induce insulin resistance. Thiazolidinediones might reverse this effect and improve insulin sensitivity.ObjectivesTo assess insulin sensitivity in CAH patients and the effect of pioglitazone treatment on insulin sensitivity in CAH patients. Secondary objectives were the effects of treatment with pioglitazone on blood pressure, body fat distribution, lipid, and steroid profiles.DesignRandomized placebo controlled crossover trial.ParticipantsTwelve CAH patients and 12 body mass and age-matched control subjects.InterventionSixteen-week treatment with pioglitazone (45 mg/day) or placebo.Main outcome measureInsulin sensitivity measured by euglycemic clamp and oral glucose tolerance test. Further measures were 24-h blood pressure profiles, body fat distribution measured by magnetic resonance imaging, dual energy x-ray absorptiometry (DEXA) and bioimpedance procedures, liver fat by magnetic resonance spectroscopy, lipid, and steroid profiles.ResultsCAH patients were insulin resistant compared with healthy controls. Treatment with pioglitazone significantly improved insulin sensitivity in CAH patients (glucose infusion rate (GIR) from 28.5±11.6 to 38.9±11.0 μmol/kg per min, P=0.000, GIR in controls 46.2±23.4 μmol/kg per min, P<0.05 versus CAH). Treatment with pioglitazone decreased blood pressure (systolic: 124.0±13.6 vs 127.0±14.9 mmHg, P<0.001, diastolic: 72.8±11.5 vs 77.4±12.6 mmHg, P<0.001). No changes in body fat distribution, lipid, and steroid profiles were observed.ConclusionsCAH patients are insulin resistant compared with matched control subjects. Treatment with pioglitazone improves insulin sensitivity and decreases blood pressure in CAH patients.

Relation between body fat distribution and insulin-resistance in women with and without obesity

1999 ◽  
Vol 144 ◽  
pp. 60
Author(s):  
A. Hernández ◽  
I. Lluch ◽  
C. Morillas ◽  
R. Royo ◽  
C. Meliá ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution

Evaluation of body fat distribution in PCOS and its association with carotid atherosclerosis and insulin resistance

2011 ◽  
Vol 28 (2) ◽  
pp. 111-114 ◽  
Author(s):  
Aysun Karabulut ◽  
Güzin Fidan Yaylali ◽  
Semra Demirlenk ◽  
Osman Sevket ◽  
Ayhan Acun
Keyword(s):  
Insulin Resistance ◽  
Body Fat ◽  
Carotid Atherosclerosis ◽  
Fat Distribution ◽  
Body Fat Distribution

scholarly journals Higher physical activity is associated with increased androgens, low interleukin 6 and less aortic calcification in peripheral obese elderly women

2008 ◽  
Vol 199 (1) ◽  
pp. 61-68 ◽  
Author(s):  
R H Straub ◽  
L B Tankó ◽  
C Christiansen ◽  
P J Larsen ◽  
D S Jessop
Keyword(s):  
Physical Activity ◽  
Body Fat ◽  
Fat Mass ◽  
Interleukin 6 ◽  
Plasma Levels ◽  
Elderly Women ◽  
Lumbar Vertebra ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Aortic Calcification

The presence of peripheral fat mass (PFM) appears to counteract the atherogenic trends of central fat mass through mechanisms presently poorly understood. In elderly women with distinct forms of body fat distribution, we wanted to study whether physical activity and aortic calcification are related to plasma levels of cortisol, 17-α-hydroxyprogesterone (17-α-OHP), dehydroepiandrosterone (DHEA), androstenedione (ASD), and interleukin 6 (IL6) accomplishing an anti-atherogenic milieu. A total of 276 well-defined generally healthy women aged 60–85 years were included. Categorization of body fat distribution was based on the relative presence of central to PFM measured by dual-energy X-ray absorptiometry. Women meticulously reported weekly physical activity. Outcome measures were aortic calcification between lumbar vertebra L1 and L4, plasma levels of hormones, and IL6. In peripheral adipose women, plasma DHEA and ASD increased with the degree of physical activity. This was also mirrored in the ratios of cortisol/DHEA and cortisol/17-α-OHP. Peripheral adipose women with high DHEA relative to cortisol had less severe aortic calcification, and in the same group a higher level of physical activity was associated with lower levels of plasma IL6. In conclusion, this study demonstrates that high physical activity is associated with a high circulating androgen to cortisol ratio, low IL6, and less severe aortic calcification. Since androgens inhibit IL6 secretion, the activity-induced increase of these hormones might be an anti-atherogenic signal.

Sign in / Sign up

Export Citation Format

Share Document