DOES A NORMAL FOETUS REALLY HAVE A FUTURE OF VALUE? A REPLY TO MARQUIS

Bioethics ◽  
2005 ◽  
Vol 19 (2) ◽  
pp. 131-145 ◽  
Author(s):  
ROBERT P. LOVERING
Keyword(s):  
Normal Foetus

scholarly journals Hydatidiform mole coexisting with normal foetus: A rare presentation of a case report from University of Maiduguri Teaching Hospital

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Abba Kabir ◽  
Abdulkarim A. Kullima ◽  
Adamu I. Adamu ◽  
Anna Peter ◽  
Abba Z. Bukar ◽  
...  
Keyword(s):  
Case Report ◽  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Close Monitoring ◽  
Ultrasound Scan ◽  
Complete Hydatidiform Mole ◽  
Intrauterine Pregnancy ◽  
Rare Presentation ◽  
Increased Risk ◽  
Normal Foetus

A twin pregnancy comprising a complete hydatidiform mole coexisting with a foetus is a rare obstetric condition with an incidence of 1 in 22,000 to 1 in 100,000 pregnancies. The management of such case is challenging due to the associated risk of maternal and foetal complications. We report a case of a 25-year-old woman, gravida 2, para 1 with a normal intrauterine pregnancy coexisting with complete hydatidiform mole. An ultrasound scan demonstrated normal foetus and placenta along with coexistent intrauterine echogenic mass with features of hydatidiform mole. The microscopic examination of the abnormal placenta confirmed complete hydatidiform mole. Although twin pregnancy with complete hydatidiform mole and coexistent foetus is associated with increased risk of developing maternal and foetal complications, continuation of pregnancy may be an acceptable option under close monitoring to detect early signs of complications.

scholarly journals Pregnancy with a Normal live Foetus and a Partial Molar Placenta - An Extremely Rare Condition

1970 ◽  
Vol 18 (1) ◽  
pp. 82-84 ◽  
Author(s):  
R Khanom ◽  
K Khatun ◽  
S Akter
Keyword(s):  
Caesarean Section ◽  
Rare Condition ◽  
Normal Karyotype ◽  
Emergency Caesarean Section ◽  
Molar Pregnancy ◽  
College Hospital ◽  
Medical College ◽  
Male Baby ◽  
Emergency Caesarean ◽  
Normal Foetus

The incidence of a normal live foetus along with a partial molar placenta is extremely rare. Although triploidy is the most frequent association, a foetus with normal karyotype can survive in cases of partial molar pregnancy. A case is reported in the Department of Obstetrics & Gynaecology, Dhaka Medical College Hospital, Dhaka that of partial molar placenta in which a live male baby was delivered at 34 weeks gestation by a 25 years old woman. At the 23rd week, ultrasonographic examination revealed a normal foetus with a huge, multicystic placenta. There were per vaginal bleeding up to the 34th gestational weeks. The patient underwent an emergency caesarean section and delivered a 1.6 kg male baby. The baby was admitted in SCABU. The foetus was normal and no complication was there. Key words: Live foetus with molar pregnancy; emergency caesarean section. DOI: 10.3329/jdmc.v18i1.6313 J Dhaka Med Coll. 2009; 18(1) : 82-84

DIFFERENCES IN 17-OXOGENIC STEROID EXCRETION IN PREGNANCIES WITH NORMAL AND ANENCEPHALIC FOETUSES

1973 ◽  
Vol 72 (1) ◽  
pp. 156-160 ◽  
Author(s):  
R. F. Heys ◽  
R. E. Oakey
Keyword(s):  
Pregnant Women ◽  
Oral Contraceptives ◽  
Normal Foetus ◽  
Steroid Excretion

ABSTRACT The 17-oxogenic steroid excretion of women pregnant with an anencephalic foetus was found to be significantly lower than that of women pregnant with a normal foetus but similar to that of non-pregnant women taking oral contraceptives containing oestrogens. It is suggested that the diminished excretion of 17-oxogenic steroids in pregnancies with an anencephalic foetus may reflect defective production of corticosteroids or their precursors by the abnormal adrenal of the anencephalic foetus.

CORTICOSTEROID PRODUCTION BY THE HUMAN FOETUS: EVIDENCE FROM ANALYSIS OF URINE FROM WOMEN PREGNANT WITH A NORMAL OR AN ANENCEPHALIC FOETUS

1976 ◽  
Vol 70 (1) ◽  
pp. 117-126 ◽  
Author(s):  
MARION L. CAWOOD ◽  
R. F. HEYS ◽  
R. E. OAKEY
Keyword(s):  
Pregnant Women ◽  
Paper Chromatography ◽  
Late Gestation ◽  
Urine Samples ◽  
Human Foetus ◽  
Maternal Urine ◽  
Normal Foetus ◽  
Analysis Of Urine

SUMMARY The quantities of nine corticosteroids in 24 h urine samples collected by pregnant women (nine with normal foetuses and nine with anencephalic foetuses) were measured after hydrolysis with β-glucuronidase and separation by paper chromatography. The excretion (μmol/24 h, mean ± s.d.) of pregnanetriol (0·85 ± 0·17), 3α,17α-dihydroxy-5β-pregnan-20-one 17α-hydroxypregnanolone, 0·55 ± 0·17), 3α,17α,21-trihydroxy-5β-pregnan-20-one (tetrahydro-11-deoxycortisol, 0·17 ± 0·14) and tetrahydrocorticosterone (0·65 ± 0·26) by women with an anencephalic foetus was significantly lower (P < 0·01 or <0·05) than the excretion of these compounds by women with a normal foetus (pregnanetriol, 2·42 ± 0·62; 17α-hydroxypregnanolone, 2·72 ± 0·69; tetrahydro-11-deoxycortisol, 0·56 ± 0·37; tetrahydrocorticosterone, 1·95 ± 0·94). These differences suggest that the adrenal of the normal foetus contributes to the quantity of pregnanetriol, 17α-hydroxypregnanolone, tetrahydro-11-deoxycortisol and tetrahydrocorticosterone in maternal urine. The excretion of tetrahydrocortisol, tetrahydrocortisone, tetrahydrodeoxycorticosterone, cortol and cortolone were similar in both groups of subjects. No evidence was obtained therefore to indicate the secretion of cortisol or deoxycorticosterone by the foetal zone of the adrenal of the undisturbed human foetus in late gestation.

OESTROGEN METABOLISM IN ANENCEPHALUS

1967 ◽  
Vol 55 (3) ◽  
pp. 369-377 ◽  
Author(s):  
Tetsuya Nakayama ◽  
Kiyoshi Arai ◽  
Takumi Yanaihara ◽  
Toru Tabei ◽  
Kazuo Satoh ◽  
...  
Keyword(s):  
Adrenal Glands ◽  
Normal Values ◽  
Specific Activity ◽  
Gradient Elution ◽  
Maternal Plasma ◽  
Point Of View ◽  
Phenolic Fraction ◽  
Specific Activities ◽  
Normal Foetus ◽  
In Pregnancy

ABSTRACT The urinary excretion and concentration of oestrogens in the cord and maternal plasma were determined in three cases of pregnancy with anencephalus. All the foetuses had atrophied adrenal glands. In the cord plasma, the overall oestrogen levels were low; oestriol was one fourth to one eighth, whereas oestrone and oestradiol were one half to the normal values. The amounts of all three oestrogens were low in the maternal plasma and urine. The placenta of an anencephalic foetus was perfused with labelled dehydroepiandrosterone (DHA), and the radioactive metabolites of the perfusate were examined. More than 90% of the radioactivity was found in the phenolic fraction, and this fraction was further separated by gradient elution partition chromatography. 39.3% and 42.8% of the radioactivity was in oestrone and oestradiol fractions respectively. Each radioactive peak was then purified by paper chromatography, and the specific activities were obtained as cpm/μg Kober chromogen. Standard carriers were added to an aliquot and recrystallized to a constant specific activity. No radioactivity could be found in the oestriol fraction. The results of this study indicate that the placenta of an anencephalic foetus can aromatize DHA in the same manner as the placenta of a normal foetus, and the results suggest that the foetal side is responsible for the abnormal oestrogen values. The possible foeto-placental relationship in pregnancy is discussed from the point of view of oestrogen metabolism.

scholarly journals Significance of the ‘line sign’ in the diagnosis of congenital imperforate anus on prenatal ultrasound

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Chan Yin ◽  
Lili Tong ◽  
Dan Nie ◽  
Zhihui Fei ◽  
Xiaoqun Tan ◽  
...  
Keyword(s):  
Imperforate Anus ◽  
Case Reports ◽  
False Negative ◽  
Ultrasound Image ◽  
Image Feature ◽  
Cross Sectional ◽  
Target Sign ◽  
Prenatal Diagnostic ◽  
Negative Case ◽  
Normal Foetus

Abstract Background The prenatal diagnosis of foetal imperforate anus is difficult. Most previous studies have been case reports. To provide useful information for diagnosing foetal imperforate anus, a retrospective review of diagnostic approaches was conducted. Ultrasonography was performed in 19 cases of foetal imperforate anus from 2016 to 2019 at our prenatal diagnostic centre. The prenatal sonographic features and outcomes of each case were collected and evaluated. Result The anal sphincter of a normal foetus shows the ‘target sign’ on cross-sectional observation. Of the 19 cases of imperforate anus, 16 cases were diagnosed by the ultrasound image feature called the ‘line sign’. 1 case with tail degeneration was low type imperforate anus with the irregular ‘target sign’ not a real ‘target sign’. There was two false-negative case, in which the ‘target sign’ was found, but irregular. Conclusion In this study, we find that the anus of a foetus with imperforate anus presents a ‘line sign’ on sonographic observation. The absence of the ‘target sign’ and then the presence of the ‘line sign’ can assist in the diagnosis of imperforate anus. The ‘line sign’ can be used as a secondary assessment to determine the type of the malformation following non visualization of the ‘target sign’. The higher the position of the imperforate anus is, the more obvious the ‘line sign’. It is worth noting that the finding of the short ‘line sign’ and irregularr ‘target sign’ can not ignore the low type imperforate anus.

STUDY THE CORRELATION BETWEEN PLACENTAL THICKNESS AND ESTIMATED FETAL WEIGHT BY 2D ULTRASONOGRAPHY ON NORMAL FOETUS MORE THAN 16 WEEKS OF AGES

2011 ◽  
pp. 58-66
Author(s):  
Thanh Nam Nguyen ◽  
Minh Loi Hoang ◽  
Vu Quoc Huy Nguyen
Keyword(s):  
Fetal Weight ◽  
The Third ◽  
Normal Foetus ◽  
Placental Thickness ◽  
Estimated Fetal Weight ◽  
Singleton Pregnancies

Objectives: To evaluate the development of foetus (BPD, AC, AAD, FL) and placenta (placental thickness - PT) and the correlation between placental thickness and fetal estimated weight. Materials and Method: Ultrasonographic study 1224 singleton pregnancies with normal developing foetus by cross-sessional describtive method from 01/05/2009 to 20/08/2010. Results: The first pregnancies consist of 59.07%, the second – 29.66 %, the third -11.28%. The fetal and placental ultrasonographic parameters continuously increase from 16 weeks to 38 weeks of age and get satistic meaning with p<0.01. There is closed agreeable correlation between BPD, AAD, AC, FL, PT and fetal ages (w) with r = 0.9829, 0.9895, 0.9882, 0.9827, 0.9689 p<0.0001 correlatively. Conclusion: Ultrasonographic fetal parameters strongly correlate with fetal ages. Placental thickness agreable correlation with fetal ages and FEW.

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