scholarly journals CD81 expression in peripheral blood lymphocytes before and after treatment with interferon and ribavirin in HIV/HCV coinfected patients

HIV Medicine ◽  
2010 ◽  
Vol 11 (3) ◽  
pp. 161-169 ◽  
Author(s):  
D Micheloud ◽  
J González-Nicolás ◽  
J Berenguer ◽  
R Lorente ◽  
P Miralles ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Before And After

scholarly journals FEATURES OF LYMPHOCYTES IN THE BLOOD IN PATIENTS WITH BASAL-LIKE BREAST CANCER SOUTH-EAST UKRAINE

2016 ◽  
Author(s):  
T. Yu. Pohorila ◽  
N. F. Shchurov ◽  
S. M. Pashchenko
Keyword(s):  
Breast Cancer ◽  
Peripheral Blood ◽  
Antitumor Immunity ◽  
Morphological Characteristics ◽  
Peripheral Blood Lymphocytes ◽  
Comprehensive Treatment ◽  
Breast Cancer Patients ◽  
Blood Lymphocytes ◽  
Before And After ◽  
Basal Like Breast Cancer

Lymphocytes are important in antitumor immunity. Therefore, the estimate of the magnitude of lymphocytes, could be used to determine the protective capabilities of the organism basal-like breast cancer patients. The purpose of the study: building a morphological features peripheral blood lymphocytes of patients with basal-like breast cancer South-East Ukraine, receiving comprehensive chemoradiotherapy. It was found that treatment BLT changes the structure of peripheral blood lymphocytes. After the comprehensive treatment of peripheral blood lymphocytes of patients significantly increased in size, they decreased nuclear-cytoplasmic ratio. For definitions immune status of patients basal-like breast cancer no small role played by morphological characteristics of lymphocytes in the peripheral blood before and after complex treatment.

scholarly journals Effect of intratumoral application of methotrexate in vivo on frequency of micronuclei in peripheral blood lymphocytes

2003 ◽  
Vol 11 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Tanja Novakovic ◽  
Olivera Milosevic-Djordjevic ◽  
Darko Grujicic ◽  
Dragoslav Marinkovic ◽  
Slobodan Jankovic ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Average Frequency ◽  
Peripheral Blood Lymphocytes ◽  
Cytostatic Drug ◽  
Blood Lymphocytes ◽  
Significant Difference ◽  
Before And After ◽  
Practice Methods ◽  
Myoma Uteri

BACKGROUND: Methotrexate is a cytostatic drug belonging to the group of antimetabolites; it is an antagonist of folic acid with an intensive application in gynecology practice. METHODS: The frequency of micronuclei (MN) in peripheral blood lymphocytes of 30 patients with myoma uteri was analyzed before and after intratumoral application of methotrexate (MTX) in total dose from 50 to 115 mg. Analysis of micronuclei was performed by the application of cytokinesis-block technique (CB). RESULTS: Average frequency of MN in lymphocytes of patients before the therapy was 4.6?0.4 MN/1000 analyzed cells. After the completion of therapy with six separate doses during six consecutive menstrual average frequency of MN increased 1.5 times (7.0?0.6) in comparison to control frequency before the therapy. Statistically significant difference (p<0.001) was established by the Student t test. CONCLUSION: Methotrexate intratumoral treatment of the myoma uteri significantly increased micronuclei in peripheral blood lymphocytes.

scholarly journals Evaluation of Micronucleus and Nuclear Division Index in the Lymphocytes of some Iraqi Patients with Acute Lymphocyte Leukemia

2013 ◽  
Vol 7 (3) ◽  
pp. 43-53
Author(s):  
Wiaam A. Al Amili ◽  
Nuria Abdul Hussain ◽  
Abdul Hussain Al Faisal
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Lymphoblastic Leukemia ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes ◽  
Before And After ◽  
Nuclear Division Index ◽  
Males And Females

The aim of our study was to determine micronucleus MN frequency and nuclear division index in peripheral blood lymphocytes of patients diagnosed with Acute Lymphoblastic Leukemia ALL, who had undergone chemotherapy. Patients were treated with nine of drugs, which included Vincristine , Methotrexate , Cytosar-U, L-asparaginase , Etoposide, , dexamethasone (Decadron) , Indoxan , Steroids. The study was carried out on fifty Iraqi patients (34 Male, 16 Female), aged 2-70 years with Acute Lymphoblastic Leukemia ALL. These samples included 20 pretreatment aged 7-70 years, 15 under treatment aged 2-57years and 15 relapsed aged 9-40 years, compared with a sample consisted of 50 apparently healthy normal individuals collected randomly from population living in Baghdad aged 3-75 years. Results of the of MN in the human lymphocyte observed a significant increase p<0.05 in the males and females of human peripheral blood lymphocytes of patients with Acute Lymphoblastic Leukemia, before and after the chemotherapy as compared with the control. While, a significant decrease P> 0.05 in nucleic division index NDI was observed in the human peripheral blood lymphocytes of Acute Lymphoblastic Leukemia Patients (males and females), before and after the chemotherapy as compared with the control. In addition, the results of MN and NDI were compared in the genders of the groups studied. In conclusion, the results indicated that there is a possibility of using the changes in the mean of MN frequency and NDI as biomarkers for the assessment of DNA damage in the human peripheral blood lymphocytes of patients with Acute Lymphoblastic Leukemia ALL before and after the chemotherapy treatment and the increase frequencies of MN in ALL patients indicate the effect of antileukemic agents in inducing somatic genetic damage.

Effects of Hodgkin Cytotoxic Serum on Blast Transformation of Normal and Hodgkin Human Peripheral Blood Lymphocytes.

1975 ◽  
Vol 61 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Sergio Tognella ◽  
Giovanni Mantovani ◽  
Gennaro S. Del Giacco ◽  
Paolo E. Manconi ◽  
Letizia Cengiarotti ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blast Transformation ◽  
Blood Lymphocytes ◽  
Cytotoxic Antibody ◽  
Human Peripheral Blood Lymphocytes ◽  
Before And After ◽  
Cytotoxic Serum

The PHA-resposiveness of normal and Hodgkin patient human peripheral blood lymphocytes has been studied before and after incubation with Hodgkin cytotoxic sera. The following conclusions have been reached: (a) Hodgkin cytotoxic serum is capable of decreasing the PHA-responsiveness of normal lymphocytes and of furtherly impairing the already defective PHA-responsiveness of Hodgkin lymphocytes. (b) The impaired PHA-responsiveness can be restored to the original levels by eluting the cytotoxic antibody. Control experiments in which normal and Hodgkin lymphocytes were put in contact with normal and Hodgkin non-cytotoxic serum showed no decrease of PHA-responsiveness. These data are in agreement with the hypothesis that the presence of serum cytotoxin is at least partly responsible for the immuno-incompetence of T-lymphocytes characteristic of Hodgkin's disease.

Sign in / Sign up

Export Citation Format

Share Document