scholarly journals Antimicrobial susceptibility patterns of Haemophilus influenzae and Streptococcus pneumoniae isolates in a Beirut general university hospital between 2000 and 2004

2006 ◽  
Vol 12 (1) ◽  
pp. 86-90 ◽  
Author(s):  
Z. Daoud ◽  
A. Cocozaki ◽  
N. Hakime
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Antimicrobial Susceptibility ◽  
University Hospital ◽  
Susceptibility Patterns

scholarly journals Antimicrobial Susceptibility Patterns and Wild-Type MIC Distributions of Anaerobic Bacteria at a German University Hospital: A Five-Year Retrospective Study (2015–2019)

Antibiotics ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 823
Author(s):  
Mohamed Tarek Badr ◽  
Benjamin Blümel ◽  
Sandra Baumgartner ◽  
Johanna M. A. Komp ◽  
Georg Häcker
Keyword(s):  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
Medical Center ◽  
Demographic Data ◽  
Anaerobic Bacteria ◽  
Empirical Therapy ◽  
Antimicrobial Susceptibility Testing ◽  
University Hospital ◽  
Comprehensive Overview ◽  
Susceptibility Patterns

Local antimicrobial susceptibility surveys are crucial for optimal empirical therapy guidelines and for aiding in antibiotic stewardship and treatment decisions. For many laboratories, a comprehensive overview of local antimicrobial susceptibility patterns of anaerobic bacteria is still lacking due to the long incubation time and effort involved. The present study investigates the antimicrobial susceptibility patterns and related clinical and demographic data of 2856 clinical isolates of anaerobic bacteria that were submitted for analysis to the Institute for Medical Microbiology and Hygiene of the Freiburg University Medical Center (a tertiary university medical center in Southern Germany) between 2015 and 2019. Antimicrobial susceptibility testing has been carried out according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guideline. Minimum inhibitory concentration (MIC)50 and MIC90 for penicillin, metronidazole, moxifloxacin, and clindamycin were established for Gram-positive anaerobes and for ampicillin-sulbactam, meropenem, metronidazole, moxifloxacin, and clindamycin for Gram-negative anaerobes. The distribution of MIC-values for various antibiotics against anaerobic bacteria was also established, especially for those having no specific breakpoints according to EUCAST guidelines. Most clinically relevant anaerobic bacteria originated from general surgery, neurological, and orthopedic wards. A high proportion of isolates were resistant to moxifloxacin and clindamycin indicating the importance of their susceptibility testing before administration. Based on our study metronidazole and other β-lactam/β-lactamase inhibitor combinations such as ampicillin-sulbactam remain suitable for empirical treatment of infections with anaerobic bacteria.

scholarly journals Ten-year surveillance of invasive Streptococcus pneumoniae isolates in central Turkey prior to the introduction of a conjugate vaccine

2010 ◽  
Vol 4 (09) ◽  
pp. 560-565 ◽  
Author(s):  
Duygu Percin ◽  
Yasemin Ay Altintop ◽  
Bulent Sumerkan
Keyword(s):  
Streptococcus Pneumoniae ◽  
Conjugate Vaccine ◽  
Antimicrobial Susceptibility ◽  
Rank Order ◽  
Age Group ◽  
Immunization Program ◽  
Conjugate Vaccines ◽  
Microbiological Methods ◽  
Central Turkey ◽  
Susceptibility Patterns

Introduction: The aim of this study was to characterize the serotypes and antimicrobial susceptibility patterns of invasive Streptococcus pneumoniae isolates in central Turkey. Methodology: A total of 332 invasive S. pneumoniae isolates were identified, serotyped and tested for antimicrobial susceptibility by routine microbiological methods. Results: The most common serogroups/serotypes were 1, 19, 3, 18, 6, 14, and 7 in rank order. Serogroup/serotype coverage of the 23-valent polysaccharide vaccine, and the 7-, 10-, and 13-valent conjugate vaccines were 96%, 44%, 78.6%, 96.4%, respectively. Overall, 20 (6%) of the isolates were resistant to penicillin, 1 (0.3%) to cefotaxime, 20 (6%) to erythromycin, 13 (4%) to cloramphenicol, and 120 (36%) to trimethoprim-sulfamethoxasole. Among cerebrospinal fluid (CSF) isolates, 20 (18.5%) were resistant to penicillin (26.3% and 11.5%, respectively, of child and adult meningitis cases; p≥0.05). Conclusions: Although the seven-valent conjugate vaccine is expected to protect less than half of children younger than three years of age, of the incorporation of this vaccine into the routine immunization program of Turkey is advised to continue. However, the 13-valent conjugate vaccine, including serotypes 1, 3, 5, and 7, has the most potential prevent the highest burden of invasive pneumococcal diseases in this age group.

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