Smooth muscle relaxant effects of tetrazepam on isolated guinea-pig and rat trachealis

1996 ◽  
Vol 16 (2) ◽  
pp. 105-110 ◽  
Author(s):  
M. D. Herrera ◽  
C. Perez-Guerrero ◽  
E. Marhuenda
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscle Relaxant ◽  
Smooth Muscle Relaxant

scholarly journals Triterpenoids, Including One with Smooth Muscle Relaxant Activity, from Rubus idaeus (Raspberry) Leaves

2006 ◽  
Vol 1 (8) ◽  
pp. 1934578X0600100
Author(s):  
Janne Rojas Vera ◽  
Christopher G. Dacke ◽  
Asmita V. Patel ◽  
Gerald Blunden
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Column Chromatography ◽  
Muscle Relaxant ◽  
Methanol Extract ◽  
Rubus Idaeus ◽  
Guinea Pig Ileum ◽  
Muscle Relaxant Activity ◽  
Smooth Muscle Relaxant

A methanol extract of Rubus idaeus leaves was fractionated by column chromatography and the eluted samples were tested for their ability to relax transmurally stimulated Guinea pig ileum preparations in vitro. Two distinct bands of activity were detected. From band one sitosterol and eight triterpenoids were characterized, but only olean-18-ene-1β, 2α, 3α-triol demonstrated smooth muscle relaxant activity. This compound is, to the best of our knowledge, novel, as are olean-12-ene-3β, 29-diol and urs-12-ene-3β, 30-diol.

Smooth Muscle Relaxant Action of Benzyl Benzoates and Salicylic Acid Derivatives fromBrickellia veronicaefoliaon Isolated Guinea-Pig Ileum

Planta Medica ◽  
2005 ◽  
Vol 71 (4) ◽  
pp. 320-325 ◽  
Author(s):  
Blanca Rivero-Cruz ◽  
María Alejandra Rojas ◽  
Rogelio Rodríguez-Sotres ◽  
Carlos M. Cerda-García-Rojas ◽  
Rachel Mata
Keyword(s):  
Smooth Muscle ◽  
Salicylic Acid ◽  
Guinea Pig ◽  
Muscle Relaxant ◽  
Guinea Pig Ileum ◽  
Salicylic Acid Derivatives ◽  
Smooth Muscle Relaxant

Smooth muscle relaxant effects of propofol and ketamine in isolated guinea-pig trachea

1993 ◽  
Vol 238 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Charles M. Pedersen ◽  
Steffen Thirstrup ◽  
Jens Erik Nielsen-Kudsk
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscle Relaxant ◽  
Smooth Muscle Relaxant

Role of extracellular calcium and calmodulin in prolactin secretion induced by hyposmolarity, thyrotropin-releasing hormone, and high K+ in GH4C1 cells

1990 ◽  
Vol 123 (2) ◽  
pp. 218-224 ◽  
Author(s):  
Xiangbing Wang ◽  
Noriyuki Sato ◽  
Monte A. Greer ◽  
Susan E. Greer ◽  
Staci McAdams
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Prolactin Secretion ◽  
Thyrotropin Releasing Hormone ◽  
Dependent Manner ◽  
Cell Toxicity ◽  
High K ◽  
Dose Dependent ◽  
Smooth Muscle Relaxant

Abstract. The mechanism by which 30% medium hyposmolarity induces PRL secretion by GH4C1 cells was compared with that induced by 100 nmol/l TRH or 30 mmol/l K+. Removing medium Ca2+, blocking Ca2+ channels with 50 μmol/l verapamil, or inhibiting calmodulin activation with 20 μmol/l trifluoperazine, 10 μmol/l chlorpromazine or 10 μmol/l pimozide almost completely blocked hyposmolarity-induced secretion. The smooth muscle relaxant, W-7, which is believed relatively specific in inhibiting the Ca2+-calmodulin interaction, depressed hyposmolarity-induced PRL secretion in a dose-dependent manner (r = −0.991, p<0.01 ). The above drugs also blocked or decreased high K+-induced secretion, but had much less effect on TRH-induced secretion. Secretion induced by TRH, hyposmolarity, or high K+ was optimal at pH 7.3-7.65 and was significantly depressed at pH 6.0 or 8.0, indicating that release of hormone induced by all 3 stimuli is due to an active cell process requiring a physiologic extracellular pH and is not produced by nonspecific cell toxicity. The data suggest hyposmolarity and high K+ may share some similarities in their mechanism of stimulating secretion, which is different from that of TRH.

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