scholarly journals Knockdown of p21Cip1/Waf1 enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells

Aging Cell ◽  
2011 ◽  
Vol 10 (2) ◽  
pp. 349-361 ◽  
Author(s):  
Tu-Lai Yew ◽  
Fang-Yao Chiu ◽  
Chih-Chien Tsai ◽  
Hen-Li Chen ◽  
Wei-Ping Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Osteogenic Potential

scholarly journals The influence of the morphology of titania and hydroxyapatite on the proliferation and osteogenic differentiation of human mesenchymal stem cells

RSC Advances ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 3843-3853
Author(s):  
Yauheni U. Kuvyrkou ◽  
Nadzeya Brezhneva ◽  
Ekaterina V. Skorb ◽  
Sviatlana A. Ulasevich
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cells ◽  
Osteogenic Potential ◽  
Titania Surface ◽  
Surface Modified ◽  
First Time ◽  
Ordered Porous ◽  
Porous Morphology

Herein, the proliferation and osteogenic potential of human mesenchymal stem cells (hMSCs) on the disordered and ordered porous morphology of the titania surface and titania surface modified by hydroxyapatite (HA) are compared for the first time.

scholarly journals Synthesis of orotic acid derivatives and their effects on stem cell proliferation

2020 ◽  
Vol 18 (1) ◽  
pp. 620-627
Author(s):  
Saeed Ali Syed ◽  
Amer Mahmood ◽  
Musaad Alfayez ◽  
Eric C. Hosten ◽  
Richard Betz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Orotic Acid ◽  
Human Mesenchymal Stem Cells ◽  
Osteogenic Potential ◽  
Biological Processes ◽  
Stem Cell Proliferation ◽  
The Past ◽  
Synthetic Scaffolds ◽  
Derivatives Of

AbstractOrotic acid, a natural product, is involved in many biological processes. Human mesenchymal stem cells (hMSCs) have the potential of self-renewable and proliferation. They are commonly isolated from the bone marrow aspirates of large bones. The osteogenic potential of these stem cells has been extensively exploited by scientists in the past to evaluate the performance of synthetic scaffolds developed for tissue engineering. In this study, N-arylhydrazone derivatives of orotic acid have been synthesized, and their potential as stimulators of human mesenchymal stem cells has been evaluated. Some of the analogs exhibit well to moderate effect on the proliferation rate.

scholarly journals In VitroCharacterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Áron Szepesi ◽  
Zsolt Matula ◽  
Anna Szigeti ◽  
György Várady ◽  
József Szalma ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Periodontal Ligament ◽  
Human Mesenchymal Stem Cells ◽  
Bone Grafts ◽  
Bone Tissue Regeneration ◽  
Osteogenic Potential ◽  
Medical Need

Bone tissue regeneration is a major, worldwide medical need, and several strategies have been developed to support the regeneration of extensive bone defects, including stem cell based bone grafts. In addition to the application of stem cells with high osteogenic potential, it is important to maintain proper blood flow in a bone graft to avoid inner graft necrosis. Mesenchymal stem cells (MSCs) may form both osteocytes and endothelial cells; therefore we examined the combinedin vitroosteogenic and endothelial differentiation capacities of MSCs derived from adipose tissue, Wharton’s jelly, and periodontal ligament. Based on a detailed characterization presented here, MSCs isolated from adipose tissue and periodontal ligament may be most appropriate for generating vascularized bone grafts.

scholarly journals In Vitro Osteogenic Potential of Human Mesenchymal Stem Cells Is Predicted by Runx2/Sox9 Ratio

2015 ◽  
Vol 21 (1-2) ◽  
pp. 115-123 ◽  
Author(s):  
Claudia Loebel ◽  
Ewa M. Czekanska ◽  
Marco Bruderer ◽  
Gian Salzmann ◽  
Mauro Alini ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Osteogenic Potential
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