Topical Methyl Aminolevulinate Photodynamic Therapy Using Red Light-Emitting Diode Light for Multiple Actinic Keratoses

2009 ◽  
Vol 35 (4) ◽  
pp. 586-592 ◽  
Author(s):  
Rolf-Markus Szeimies ◽  
Robert T. Matheson ◽  
Steven A. Davis ◽  
Ashish C. Bhatia ◽  
Yvonne Frambach ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Emitting Diode ◽  
Red Light ◽  
Light Emitting ◽  
Actinic Keratoses ◽  
Methyl Aminolevulinate

scholarly journals Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device

2015 ◽  
Vol 08 (04) ◽  
pp. 1550017 ◽  
Author(s):  
Xuewei Jiang ◽  
Zhichao Fan ◽  
Yili Yu ◽  
Chenying Shao ◽  
Yuanzhen Suo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Toluidine Blue ◽  
Pathogenic Bacteria ◽  
Light Emitting Diode ◽  
Red Light ◽  
In Vitro Screening ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Prevotella Melaninogenica

Photodynamic therapy (PDT) has been commonly used in treating many diseases, such as cancer and infectious diseases. We investigated the different effects of PDT on three main pathogenic bacteria of periodontitis — Prevotella melaninogenica (P.m.), Porphyromonas gingivalis (P.g.) and Aggregatibacter actinomycetemcomitans (A.a.). The portable red light-emitting diode (LED) phototherapy device was used to assess the exogenous PDT effects with different light doses and photosensitizer concentrations (Toluidine blue O, TBO). The portable blue LED phototherapy device was used to assess the endogenous PDT effects with the use of endogenous photosensitizers (porphyrin) under different light doses. We found out that both exogenous and endogenous PDT were able to restrict the growth of all the three bacteria significantly. Moreover, the optimal PDT conditions for these bacteria were obtained through this in vitro screening and could guide the clinical PDT on periodontitis.

scholarly journals Comparison of Photodynamic Therapy Using a Green or Red Light-Emitting Diode with Computer Simulation

2016 ◽  
Vol 44 (3) ◽  
pp. 187
Author(s):  
Hisanao HAZAMA ◽  
Norihiro HONDA ◽  
Hideo FUKUHARA ◽  
Keiji INOUE ◽  
Taro SHUIN ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Photodynamic Therapy ◽  
Light Emitting Diode ◽  
Red Light ◽  
Light Emitting

scholarly journals No-Needle Jet Intradermal Aminolevulinic Acid Photodynamic Therapy for Recurrent Nodular Basal Cell Carcinoma of the Nose: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Daniel Barolet ◽  
Annie Boucher
Keyword(s):  
Photodynamic Therapy ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
High Speed ◽  
Aminolevulinic Acid ◽  
Light Emitting Diode ◽  
Red Light ◽  
Light Emitting ◽  
Total Fluence

Photodynamic therapy (PDT) with aminolevulinic acid (ALA) to treat nodular basal cell carcinoma (BCC) has been shown to be beneficial. The success rate of ALA-PDT in the treatment of nodular BCC is dependent on optimal penetration of the photosensitizing agent and subsequent PpIX production. To enhance topical delivery of drugs intradermally, a needleless jet injection (NLJI), which employs a high-speed jet to puncture the skin without the side effects of needles, was used in one patient with recurrent BCC of the nose. Photoactivation was then performed using red light emitting diode [CW@ λ630 nm, irradiance 50 mW/cm2, total fluence 51 J/cm2] for 17 minutes. Excellent cosmesis was obtained. Aside from mild crusting present for six days, no other adverse signs were noted. Clinically, there was no recurrent lesion up two years postintervention. Additional studies in larger samples of subjects are needed to further evaluate this promising technique.

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