Comparison of the Rheological Properties of Viscosity and Elasticity in Two Categories of Soft Tissue Fillers: Calcium Hydroxylapatite and Hyaluronic Acid

2010 ◽  
Vol 36 (Suppl 3) ◽  
pp. 1859-1865 ◽  
Author(s):  
HEMA SUNDARAM ◽  
BOB VOIGTS ◽  
KENNETH BEER ◽  
MELISSA MELAND
Keyword(s):  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Rheological Properties ◽  
Calcium Hydroxylapatite

scholarly journals Rheological Properties of İnjectable Hyaluronic Acid Hydrogels for Soft Tissue Engineering Applications

2020 ◽  
Vol 11 (1) ◽  
pp. 8424-8430
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Rheological Properties ◽  
Three Dimensional ◽  
Diglycidyl Ether ◽  
Potential Candidate ◽  
Engineering Applications ◽  
Crosslinker Concentration ◽  
Soft Tissue Engineering

Hydrogels are cross-linked three-dimensional (3D) polymeric network, which can hold the water within its porous structure. They have recently been used in various biomedical applications. In this study, injectable hyaluronic acid (HA) hydrogels were prepared using different concentrations of 1,4-butanediol diglycidyl ether (BDDE) as a crosslinker (1-5% w/w) and investigated their rheological, swelling and injectability properties. The results demonstrated that the rheological characteristics of hydrogels enhanced with increasing crosslinker concentration. The elastic modulus of the hydrogels ranged from 280 Pa to 990 Pa, while the complex viscosities were found between 42 Pa.s and 190 Pa.s at an oscillation frequency of 1 Hz. These results clearly suggest that the injectable HA hydrogels are a potential candidate for various soft tissue engineering applications due to their highly tunable rheological properties.

scholarly journals In Vitro Evaluation of the Sensitivity of a Hyaluronic Acid PEG Cross-Linked to Bovine Testes Hyaluronidase

2018 ◽  
Vol 6 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Nicola Zerbinati ◽  
Torello Lotti ◽  
Damiano Monticelli ◽  
Virginia Martina ◽  
Giovanna Cipolla ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Chemical Reaction ◽  
Time Course ◽  
Soft Tissue Augmentation ◽  
Facial Soft Tissue ◽  
Microplate Reader ◽  
Kinetics Of

Neauvia Intense is biocompatible, injectable hyaluronic acid (HA) filler PEG cross-linked for facial soft-tissue augmentation that provides volume to tissues. The aim of the present study is to evaluate the sensitivity of Neauvia Intense in hyaluronidase from bovine testes in a time-course analysis. The test is based on the colourimetric determination of the N-acetyl – D - glucosamine (NAG) released by the hyaluronidase in standardised conditions. The in vitro conditions involve the treatment of Neauvia Intense with a known concentration of the enzyme (6080U/ml). The NAG content was determined at different times to assess the kinetics of the degradation (1h, 3h, 6h, 24h, 48h, 72h, 120h, and 168h); the Ehrlich’s reagent was used for the colourimetric quantification, by the method described by Reissing and colleagues. The intensity of the violet colour developed after the chemical reaction was proportional to the NAG present in each sample. A microplate reader at 585 nm read the absorbance. The amount of NAG released by the product was proportional to the time of incubation with bovine hyaluronidase, reaching a plateau after 168 hours.

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