A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran

2006 ◽  
Vol 16 (1) ◽  
pp. 257-261 ◽  
Author(s):  
N. IZADI MOOD ◽  
Z. EFTEKHAR ◽  
A. HARATIAN ◽  
L. SAEEDI ◽  
P. RAHIMI-MOGHADDAM ◽  
...  
Keyword(s):  
Cervical Screening ◽  
Screening Tests ◽  
Cervical Smears ◽  
Glandular Cells ◽  
Atypical Glandular Cells

scholarly journals More focus on atypical glandular cells in cervical screening: Risk of significant abnormalities and low histological follow-up rate

CytoJournal ◽  
2020 ◽  
Vol 17 ◽  
pp. 22
Author(s):  
Pingping Zhong ◽  
Chenghong Yin ◽  
Yulan Jin ◽  
Tianbao Chen ◽  
Yang Zhan ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Cervical Screening ◽  
Close Relation ◽  
Prior History ◽  
Pap Smears ◽  
Chi Square ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Chi Square Test

Objectives: Atypical glandular cells (AGC) detected by Papanicolaou (Pap) smears are in close relation with adenocarcinoma and precursors detected by histopathology. Yet, sometimes the cytological diagnosis of AGC has been neglected. With increase of adenocarcinoma and precursors, we need more focus on glandular abnormalities. Material and Methods: Clinicopathological data of patients who had AGC on Pap smears between April 2015 and October 2018 and underwent histological follow-up were retrieved from the computerized database of Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Patients with a prior history of cancer were excluded from the study. Statistical analyses were performed using Pearson’s Chi-square test in SPSS software version 23. P < 0.05 (two sided) was considered as statistical significance. Results: Liquid-based cytological examination of the uterine cervix was carried out in 164,080 women. Five hundred and twenty-five women were diagnosed with AGC, 314 with not otherwise specified (AGC-NOS), and 211 with favor neoplastic (AGC-FN). Only 310 cases had histological follow-up, 168 women (168/314, 53.5%) originally with AGC-NOS on Pap smears, and 142 (142/211, 67.3%) with AGC-FN. The median age of histological significant abnormalities was 46.7 years, and 126 women (126/162, 77.8%) were postmenopausal. Sixty-six cases (66/168, 39.3%) of AGC-NOS had significant abnormalities (96/142, 67.6%, AGC-FN). One hundred and sixty-two cases of significant abnormalities included 40 high-grade squamous abnormalities and 122 glandular abnormalities. AGC-FN was more likely to be associated with a clinically significant abnormalities (P < 0.001) compared to AGC-NOS. Conclusions: Patients with AGC on Pap smears are in close relation with significant abnormalities, especially with significant glandular abnormalities on histopathology slices. AGC should be evaluated vigilantly with histological workup, especially if patients are diagnosed with AGC-FN and are aged 41–60 years. We need more focus on AGC.

scholarly journals Risk of invasive cervical cancer after atypical glandular cells in cervical screening: nationwide cohort study

BMJ ◽  
2016 ◽  
pp. i276 ◽  
Author(s):  
Jiangrong Wang ◽  
Bengt Andrae ◽  
Karin Sundström ◽  
Peter Ström ◽  
Alexander Ploner ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cohort Study ◽  
Cervical Screening ◽  
Invasive Cervical Cancer ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Histologic Correlation of Atypical Glandular Cells in Cervical Smears

2009 ◽  
Vol 43 (5) ◽  
pp. 453 ◽  
Author(s):  
Yi Kyeong Chun ◽  
Sung Ran Hong ◽  
Hye Sun Kim ◽  
Ji Young Kim ◽  
Hy Sook Kim
Keyword(s):  
Cervical Smears ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Atypical glandular cells on cervical smears

2002 ◽  
Vol 78 (3) ◽  
pp. 227-234 ◽  
Author(s):  
C.I. Parellada ◽  
P.L. Schivartche ◽  
E.A. Pereyra ◽  
A.C. Chuery ◽  
S.M.G. Mioni ◽  
...  
Keyword(s):  
Cervical Smears ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Atypical Glandular Cells of Undetermined Significance in Cervical Smears After Conization

2001 ◽  
Vol 45 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Sung Ran Hong ◽  
Jong Sook Park ◽  
Hy Sook Kim
Keyword(s):  
Cervical Smears ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Undetermined Significance

scholarly journals Cervical Lesion: Types and Etiology

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Fasogbon Samuel Ayobami
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cervical Screening ◽  
Cervical Lesion ◽  
Early Age ◽  
Related Factors ◽  
Squamous Cells ◽  
Multiple Sex Partners ◽  
Glandular Cells ◽  
Atypical Glandular Cells

A cervical lesion is an area of abnormal tissue found on the cervix, which is the lower end of a woman’s uterus. The type of the lesion can be atypical squamous cells, squamous intraepithelianeoplasia, and atypical glandular cells. The early stages of cervical cancer may be asymptomatic. In advanced disease, there may be metastases to the abdomen, lungs or any other organ. Infection with some types of human papilloma virus (HPV) is the highest risk factor for cervical cancer which can be transmitted due to multiple sex partners, followed by smoking. Other risk factors include human immunodeficiency virus (HIV), early age at first sexual intercourse, early age at first pregnancy, tobacco use, exposure to passive smoke and other related factors. It is therefore recommended that all the risk factors should be avoided to reduce cervical cancer in the society and women should go for regular cervical screening as early detection can easily be treated.

scholarly journals Comparison of the Histologic Results of Atypical Glandular Cells-Favor Neoplasia and Atypical Glandular Cells-Not Otherwise Specified

2016 ◽  
Vol 22 (1) ◽  
Author(s):  
Alper Karalök ◽  
Özgür Koçak ◽  
Tolga Taşçı ◽  
Bülent Yırcı ◽  
Işın Üreyen ◽  
...  
Keyword(s):  
Pap Smear ◽  
Screening Tests ◽  
Cytologic Examination ◽  
Screening Programs ◽  
Not Otherwise Specified ◽  
Significant Difference ◽  
Risk Of Malignancy ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Group A

<p>Objective: Cervical cancer screening programs are widely performed in all around the world. The interpretation of the Pap smear test is a big challenge in gynecology practice particularly when associated with atypical glandular cells. In this study, we performed a retrospective analysis of cytologic results associated with atypical glandular cells in our institution.<br />Material and Method: We retrospectively reviewed Pap smear tests resulted as “atypical glandular cells”. A total of 122 women had screening tests reported as “atypical glandular cells” between 2003 and 2013 at the Ministry of Health, Etlik Maternity and Women’s Health Teaching Research. The cytology reported as “atypical glandular cells” were evaluated in two main groups: Atypical glandular cells-favor neoplasia (AGC-FN) and atypical glandular cells-not otherwise specified (AGC-NOS) compared by means of histologic results.<br />Results: Thirty-two women have been reported as AGC-NOS on cytologic examination and 90 women were defined as AGC-FN. There was no significant difference between AGC-FN and AGC NOS groups in terms of age. In AGC-FN group, a total of 13 women (13/90) (14.4%) had malignant histological diagnosis. In AGC-NOS group only one woman (1/32) (3.1%) was diagnosed as malignant. All the malignant cases in this study are older than 35 years.<br />Conclusion: The incidence of AGC is less than 1% in all Pap smear examinations. Two main factors were important in the outcome of the AGC. The first one is the subgroup. AGC-FN group has a higher risk of malignancy. The second important factor is the age of the patient. To be older than 35 years old seems to increase the risk of malignancy.<br /><br /></p>

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