scholarly journals Comparison of the Histologic Results of Atypical Glandular Cells-Favor Neoplasia and Atypical Glandular Cells-Not Otherwise Specified

2016 ◽  
Vol 22 (1) ◽  
Author(s):  
Alper Karalök ◽  
Özgür Koçak ◽  
Tolga Taşçı ◽  
Bülent Yırcı ◽  
Işın Üreyen ◽  
...  
Keyword(s):  
Pap Smear ◽  
Screening Tests ◽  
Cytologic Examination ◽  
Screening Programs ◽  
Not Otherwise Specified ◽  
Significant Difference ◽  
Risk Of Malignancy ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Group A

<p>Objective: Cervical cancer screening programs are widely performed in all around the world. The interpretation of the Pap smear test is a big challenge in gynecology practice particularly when associated with atypical glandular cells. In this study, we performed a retrospective analysis of cytologic results associated with atypical glandular cells in our institution.<br />Material and Method: We retrospectively reviewed Pap smear tests resulted as “atypical glandular cells”. A total of 122 women had screening tests reported as “atypical glandular cells” between 2003 and 2013 at the Ministry of Health, Etlik Maternity and Women’s Health Teaching Research. The cytology reported as “atypical glandular cells” were evaluated in two main groups: Atypical glandular cells-favor neoplasia (AGC-FN) and atypical glandular cells-not otherwise specified (AGC-NOS) compared by means of histologic results.<br />Results: Thirty-two women have been reported as AGC-NOS on cytologic examination and 90 women were defined as AGC-FN. There was no significant difference between AGC-FN and AGC NOS groups in terms of age. In AGC-FN group, a total of 13 women (13/90) (14.4%) had malignant histological diagnosis. In AGC-NOS group only one woman (1/32) (3.1%) was diagnosed as malignant. All the malignant cases in this study are older than 35 years.<br />Conclusion: The incidence of AGC is less than 1% in all Pap smear examinations. Two main factors were important in the outcome of the AGC. The first one is the subgroup. AGC-FN group has a higher risk of malignancy. The second important factor is the age of the patient. To be older than 35 years old seems to increase the risk of malignancy.<br /><br /></p>

scholarly journals Comparison Between Pap Smear and Via As Screening For Cervical Lesions

2013 ◽  
Vol 1 (03) ◽  
pp. 55-60
Author(s):  
V. Harshini ◽  
Amritha Bhandary ◽  
Suchithra Thunga
Keyword(s):  
Acetic Acid ◽  
Visual Inspection ◽  
Pap Smear ◽  
Screening Tests ◽  
Cervical Lesions ◽  
Low Resource Settings ◽  
Screening Programs ◽  
Low Resource ◽  
The Subject ◽  
Systemic Examination

Introduction: An important reason for higher cervical cancer incidence in developing countries is lack of effective screening programs like pap smear, aimed at detecting precancerous conditions before they progress to invasive cancer. The potential difficulties in implementing cervical cytology based screening in low-resource settings have prompted the investigation of accuracy of alternative low technology tests such as Visual inspection with acetic acid application [VIA], Visual inspection with acetic acid application with magnification [VIAM], visual inspection on Lugol’s Iodine application [VILI] in early detection of cervical neoplasia .In our study we compared pap smear with VIA to study the accurarcy of VIA as it is simpler and easier technique to be used as screening in low resource settings. Aim: This is a hospital based descriptive, prospective study to evaluate validity of pap smear and VIA techniques as screening tests in identifying cervical lesions. Materials And Methods: After general and systemic examination as a routine,visual local pelvic examination including visualisation of cervix and vagina per speculum and the findings are documented in the proforma .Then VIA and pap smear are done in that order, if any of these tests are positive then cervical biopsy will be taken and further advise to the subject is given. Results: A total of 313 women were involved in the study. The sensitivity of pap smear is 54.5% specificity is 98.9% while that of VIA 95.4% and 97.9%respectively. We found that VIA accuracy was comparatively more than that of pap smear. Conclusion: In low resource settings, usefulness of VIA is more than that of pap smear. We suggest to perform VIA in all the women inspite of having pap smear facility to improve detection rate of cervical lesions and provide better patient councelling and treatment.

Promising strategies for cervical cancer screening in the post-human papillomavirus vaccination era

Sexual Health ◽  
2010 ◽  
Vol 7 (3) ◽  
pp. 376 ◽  
Author(s):  
Joseph Tota ◽  
Salaheddin M. Mahmud ◽  
Alex Ferenczy ◽  
François Coutlée ◽  
Eduardo L. Franco
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Human Error ◽  
Pap Smear ◽  
Cervical Screening ◽  
Screening Tests ◽  
Hpv Testing ◽  
Human Papillomavirus Vaccination ◽  
Screening Programs

Human papillomavirus (HPV) vaccination is expected to reduce the burden of cervical cancer in most settings; however, it is also expected to interfere with the effectiveness of screening. In the future, maintaining Pap cytology as the primary cervical screening test may become too costly. As the prevalence of cervical dysplasias decreases, the positive predictive value of the Pap test will also decrease, and, as a result, more women will be referred for unnecessary diagnostic procedures and follow-up. HPV DNA testing has recently emerged as the most likely candidate to replace cytology for primary screening. It is less prone to human error and much more sensitive than the Pap smear in detecting high-grade cervical lesions. Incorporating this test would improve the overall quality of screening programs and allow spacing out screening tests, while maintaining safety and lowering costs. Although HPV testing is less specific than Pap cytology, this issue could be resolved by reserving the latter for the more labour-efficient task of triaging HPV-positive cases. Because most HPV-positive smears would contain relevant abnormalities, Pap cytology would be expected to perform with sufficient accuracy under these circumstances. HPV Pap triage would also provide a low-cost strategy to monitor long-term vaccine efficacy. Although demonstration projects could start implementing HPV testing as a population screening tool, more research is needed to determine the optimal age to initiate screening, the role of HPV typing and other markers of disease progression, and appropriate follow-up algorithms for HPV-positive and Pap-negative women.

The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

2015 ◽  
Vol 59 (4) ◽  
pp. 315-318 ◽  
Author(s):  
Chiung-Ru Lai ◽  
Chih-Yi Hsu ◽  
Jen-Fan Hang ◽  
Anna Fen-Yau Li
Keyword(s):  
Pap Smear ◽  
Diagnostic Value ◽  
Routine Screening ◽  
Pap Smears ◽  
Cervical Lesions ◽  
Endometrial Cells ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Endometrial Cancers ◽  
New Criteria

Objective: The presence of degenerative endometrial debris and abnormal endometrial cells is considered to be the hint for endometrial pathology. The purpose of this study was to evaluate the efficacy of Papanicolaou (Pap) smears in detecting endometrial cancers. Study Design: There were 146 cases of endometrial cancer diagnosed at our institute in 2000-2002 and 271 in 2010-2012. Among them, 57 and 95 relevant reports of Pap smears 6 months prior to the histology diagnosis were retrieved for this study, respectively. In the first time period, new criteria for detecting endometrial lesions had not yet been incorporated into routine screening. Results: Twenty cases (21%) of adenocarcinoma, 12 (13%) of atypical glandular cells, 4 (4%) of endometrial debris and 59 (62%) negative reports were found among the more recent 95 relevant Pap smears. The overall efficacy of the Pap smear for detecting endometrial malignancy was 38%, higher than 10 years previously (30%). Conclusion: Although the Pap smear was originally designed to screen cervical lesions, more effective detection of endometrial lesions could be achieved by adding new criteria to the routine screening.

A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran

2006 ◽  
Vol 16 (1) ◽  
pp. 257-261 ◽  
Author(s):  
N. IZADI MOOD ◽  
Z. EFTEKHAR ◽  
A. HARATIAN ◽  
L. SAEEDI ◽  
P. RAHIMI-MOGHADDAM ◽  
...  
Keyword(s):  
Cervical Screening ◽  
Screening Tests ◽  
Cervical Smears ◽  
Glandular Cells ◽  
Atypical Glandular Cells

scholarly journals Atypical glandular cells in pap smear as a primarily presentation of ovarian serous borderline tumor

2021 ◽  
Vol 49 (2-3) ◽  
pp. 138-142
Author(s):  
Danijela Jurič ◽  
Ana Barišić ◽  
Sanda Rajhvajn ◽  
Vesna Mahovlić ◽  
Davor Petrović ◽  
...  
Keyword(s):  
Pap Smear ◽  
Borderline Tumor ◽  
Serous Borderline Tumor ◽  
Glandular Cells ◽  
Atypical Glandular Cells
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