Gas-Exchange Function of a Preprimed Pediatric Oxygenator Stored for One Year for Emergency Cardiopulmonary Bypass

To determine the extent and sources of adaptive response in gas-exchange to major lung resection during somatic maturation, immature male foxhounds underwent right pneumonectomy (R-Pnx, n = 5) or right thoracotomy without pneumonectomy (Sham, n = 6) at 2 mo of age. One year after surgery, exercise capacity and pulmonary gas-exchange were determined during treadmill exercise. Lung diffusing capacity (Dl) and cardiac output were measured by a rebreathing technique. In animals after R-Pnx, maximal O2 uptake, lung volume, arterial blood gases, and Dl during exercise were completely normal. Postmortem morphometric analysis 18 mo after R-Pnx ( n = 3) showed a vigorous compensatory increase in alveolar septal tissue volume involving all cellular compartments of the septum compared with the control lung; as a result, alveolar-capillary surface areas and Dl estimated by morphometry were restored to normal. In both groups, estimates of Dl by the morphometric method agreed closely with estimates obtained by the physiological method during peak exercise. These data show that extensive lung resection in immature dogs stimulates a vigorous compensatory growth of alveolar tissue in excess of maturational lung growth, resulting in complete normalization of aerobic capacity and gas-exchange function at maturity.

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CO2 and Lung Mechanical or Gas Exchange Function: The authors reply

Critical Care Medicine ◽

10.1097/01.ccm.0000126381.52335.ec ◽

2004 ◽

Vol 32 (5) ◽

pp. 1240-1241

Author(s):

John G. Laffey ◽

Brian P. Kavanagh

Keyword(s):

Gas Exchange ◽

Exchange Function

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Antioxidant and multi-sensitive PNIPAAm/keratin double network gels for self-stripping wound dressing application

Journal of Materials Chemistry B ◽

10.1039/d1tb00702e ◽

2021 ◽

Author(s):

Xiao Han ◽

Yang Rong ◽

Xiuzhen Wan ◽

Jie Dou ◽

Jiang Yuan ◽

...

Keyword(s):

Gas Exchange ◽

Absorptive Capacity ◽

Wound Dressing ◽

Tissue Fluid ◽

Double Network ◽

Humid Environment ◽

Exchange Function

Hydrogel is a potential wound dressing material due to its ability to maintain a humid environment, the strong absorptive capacity of exuded tissue ﬂuid, and gas exchange function. Herein, poly(N-isopropyl...

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Additional veno-venous gas exchange as a problem-solving strategy for an oxygenator not transferring oxygen in paediatric cardiopulmonary bypass†

Interactive Cardiovascular and Thoracic Surgery ◽

10.1093/icvts/ivx192 ◽

2017 ◽

Vol 25 (5) ◽

pp. 687-689

Author(s):

Wolfgang Boettcher ◽

Nicodème Sinzobahamvya ◽

Frank Dehmel ◽

Andreas Matschke ◽

Andre Iben ◽

...

Keyword(s):

Cardiopulmonary Bypass ◽

Problem Solving ◽

Gas Exchange ◽

Problem Solving Strategy ◽

Solving Strategy

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Physiological and anatomical responses of Eucalyptus camaldulensis leaves to glyphosate application

Advances in Forestry Science ◽

10.34062/afs.v8i3.12483 ◽

2021 ◽

Vol 8 (3) ◽

pp. 1535-1543

Author(s):

Diego Meloni ◽

Carlos Arberto Martínez ◽

María Gabriela Targa ◽

Alicia Fraño ◽

Alejandra Catán

Keyword(s):

Gas Exchange ◽

Chlorophyll A ◽

Mechanism Of Action ◽

Fluorescence Emission ◽

Eucalyptus Camaldulensis ◽

Plant Leaves ◽

Ionic Homeostasis ◽

Usual Practice ◽

One Year ◽

Anatomical Parameters

The use of herbicides is a usual practice in E. camaldulensis nurseries and plantations. The most widely used herbicide is glyphosate, whose drift damages this plant leaves. Although the mechanism of action of glyphosate is well known, it is not clear which alterations lead to the death of plants. The aim of this work was to assess the physiological and anatomical responses of leaves of E. camaldulensis seedlings to glyphosate application. Tests were performed on one-year-old seedlings sprayed with 0, 65 and 130 g a.e. ha-1 glyphosate. Ten days after the application, we measured gas exchange and fluorescence emission of chlorophyll a. We also quantify the concentrations of chlorophyll a, shikimate, carbohydrates, K+ and Mg2+, and the anatomical parameters of epidermis and mesophyll. Data was contrasted using Fisher’s test (p<0.05). We concluded that glyphosate alters the physiology of E. camaldulensis, inhibiting photosynthesis, changing the metabolism of carbohydrates and the ionic homeostasis. Tissue disorganization, heavily marked at the level of mesophyll, indicates definite alterations.

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Gas Exchange Function of the Middle Ear Mucosa in Patients with Cleft Palate.

Practica Oto-Rhino-Laryngologica ◽

10.5631/jibirin.91.227 ◽

1998 ◽

Vol 91 (3) ◽

pp. 227-231

Author(s):

Makito TANABE ◽

Haruo Takahashi ◽

Iwao HONJI ◽

Masaki SAWADA

Keyword(s):

Gas Exchange ◽

Cleft Palate ◽

Middle Ear ◽

Middle Ear Mucosa ◽

Exchange Function

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Contribution of cardiogenic oscillations to gas exchange in constant-flow ventilation

Journal of Applied Physiology ◽

10.1152/jappl.1987.63.2.564 ◽

1987 ◽

Vol 63 (2) ◽

pp. 564-570 ◽

Cited By ~ 19

Author(s):

I. J. Cybulsky ◽

J. G. Abel ◽

A. S. Menon ◽

T. A. Salerno ◽

S. V. Lichtenstein ◽

...

Keyword(s):

Cardiac Arrest ◽

Cardiopulmonary Bypass ◽

Ventricular Fibrillation ◽

Gas Exchange ◽

Alveolar Ventilation ◽

Constant Flow ◽

Left Heart ◽

Left Heart Bypass ◽

Cardiogenic Oscillations ◽

Heart Bypass

The contribution of cardiogenic oscillations to gas exchange during constant-flow ventilation was examined in 11 dogs. With the use of two variations of cardiopulmonary bypass to maintain the systemic and pulmonary circulation, the influence of cardiogenic oscillations was removed by arresting the heart. Cardiac arrest by ventricular fibrillation was associated with a mean decrease in alveolar ventilation of 43% in five dogs on right and left heart bypass. However, successful defibrillation and return of the prearrest level of alveolar ventilation could not be achieved; thus we studied six dogs on left heart bypass. Alveolar ventilation decreased an average of 37% with cardiac arrest, and defibrillation resulted in a return of alveolar ventilation to 81% of the prearrest value. These results are consistent with previous predictions that cardiogenic oscillations are an important mechanism of gas transport during constant-flow ventilation.

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Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129Xe MRI

Science Advances ◽

10.1126/sciadv.abc8180 ◽

2020 ◽

Vol 7 (1) ◽

pp. eabc8180

Author(s):

Haidong Li ◽

Xiuchao Zhao ◽

Yujin Wang ◽

Xin Lou ◽

Shizhen Chen ◽

...

Keyword(s):

Lung Function ◽

Gas Exchange ◽

Recovery Process ◽

Blood Exchange ◽

Structural Abnormalities ◽

Hyperpolarized 129Xe ◽

Magnetic Resonance Imaging Mri ◽

And Function ◽

Exchange Function ◽

The Impact

The recovery process of COVID-19 patients is unclear. Some recovered patients complain of continued shortness of breath. Vasculopathy has been reported in COVID-19, stressing the importance of probing pulmonary microstructure and function at the alveolar-capillary interface. While computed tomography (CT) detects structural abnormalities, little is known about the impact of disease on lung function. 129Xe magnetic resonance imaging (MRI) is a technique uniquely capable of assessing ventilation, microstructure, and gas exchange. Using 129Xe MRI, we found that COVID-19 patients show a higher rate of ventilation defects (5.9% versus 3.7%), unchanged microstructure, and longer gas-blood exchange time (43.5 ms versus 32.5 ms) compared with healthy individuals. These findings suggest that regional ventilation and alveolar airspace dimensions are relatively normal around the time of discharge, while gas-blood exchange function is diminished. This study establishes the feasibility of localized lung function measurements in COVID-19 patients and their potential usefulness as a supplement to structural imaging.

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