scholarly journals Single-Nucleotide Polymorphisms in Corticotropin Releasing Hormone Receptor 1 Gene (CRHR1) Are Associated With Quantitative Trait of Event-Related Potential and Alcohol Dependence

2010 ◽  
Vol 34 (6) ◽  
pp. 988-996 ◽  
Author(s):  
Andrew C. H. Chen ◽  
Niklas Manz ◽  
Yongqiang Tang ◽  
Madhavi Rangaswamy ◽  
Laura Almasy ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Alcohol Dependence ◽  
Quantitative Trait ◽  
Hormone Receptor ◽  
Event Related Potential ◽  
Nucleotide Polymorphisms ◽  
Corticotropin Releasing Hormone ◽  
Single Nucleotide ◽  
Releasing Hormone

scholarly journals Ethnic-Specific Genetic Association of Variants in the Corticotropin-Releasing Hormone Receptor 1 Gene with Nicotine Dependence

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Xiujun Tang ◽  
Shumin Zhan ◽  
Liping Yang ◽  
Wenyan Cui ◽  
Jennie Z. Ma ◽  
...  
Keyword(s):  
Association Analysis ◽  
Hormone Receptor ◽  
Multiple Testing ◽  
Nucleotide Polymorphisms ◽  
Corticotropin Releasing Hormone ◽  
Single Nucleotide ◽  
Releasing Hormone ◽  
Smoking Quantity ◽  
Smoking Addiction ◽  
Smoking Index

Twin and family studies indicate that smoking addiction is highly influenced by genetic factors. Variants in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression. In this study, we tested five single nucleotide polymorphisms (SNPs) inCRHR1for their association with ND, which was assessed by smoking quantity (SQ), the Heaviness of Smoking Index (HSI), and the Fagerström test for ND (FTND) in 2,037 subjects from 602 families of either European American (EA) or African American (AA) ancestry. Association analysis of the five SNPs revealed a significant association of rs171440 with SQ in the AA sample and with SQ and FTND in the pooled AA and EA samples. Haplotype-based association analysis indicated significant association of haplotypes C-C (56.9%) and T-C (38.9%), formed by SNPs rs171440 and rs1396862, with SQ in the AA sample, C-C-G (47.6%) with SQ, and T-C-G (42.3%), formed by SNPs rs171440, rs1396862, and rs878886, with SQ and FTND in the pooled AA and EA samples. However, none of these associations remained significant after correction for multiple testing. Together, our results provide suggestive evidence for the involvement ofCRHR1in ND, which warrants further investigation using larger independent samples.

scholarly journals Accuracy of marker-assisted selection with single markers and marker haplotypes in cattle

2007 ◽  
Vol 89 (4) ◽  
pp. 215-220 ◽  
Author(s):  
B. J. HAYES ◽  
A. J. CHAMBERLAIN ◽  
H. McPARTLAN ◽  
I. MACLEOD ◽  
L. SETHURAMAN ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
Quantitative Trait Loci ◽  
Single Nucleotide Polymorphisms ◽  
Quantitative Trait ◽  
Marker Assisted Selection ◽  
Nucleotide Polymorphisms ◽  
Data Set ◽  
Single Nucleotide ◽  
Angus Cattle ◽  
Genome Wide

SummaryA key question for the implementation of marker-assisted selection (MAS) using markers in linkage disequilibrium with quantitative trait loci (QTLs) is how many markers surrounding each QTL should be used to ensure the marker or marker haplotypes are in sufficient linkage disequilibrium (LD) with the QTL. In this paper we compare the accuracy of MAS using either single markers or marker haplotypes in an Angus cattle data set consisting of 9323 genome-wide single nucleotide polymorphisms (SNPs) genotyped in 379 Angus cattle. The extent of LD in the data set was such that the average marker–marker r2 was 0·2 at 200 kb. The accuracy of MAS increased as the number of markers in the haplotype surrounding the QTL increased, although only when the number of markers in the haplotype was 4 or greater did the accuracy exceed that achieved when the SNP in the highest LD with the QTL was used. A large number of phenotypic records (>1000) were required to accurately estimate the effects of the haplotypes.

Sign in / Sign up

Export Citation Format

Share Document