ASSOCIATION BETWEEN SERUM 25-HYDROXYVITAMIN D CONCENTRATIONS AND VISION: A CROSS-SECTIONAL POPULATION-BASED STUDY OF OLDER ADULTS

2011 ◽  
Vol 59 (3) ◽  
pp. 568-570 ◽  
Author(s):  
Olivier Beauchet ◽  
Dan Milea ◽  
Alix Graffe ◽  
Bruno Fantino ◽  
Cédric Annweiler
2016 ◽  
Vol 36 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Wysllenny N. de Souza ◽  
Marina M. Norde ◽  
Érica Oki ◽  
Marcelo M. Rogero ◽  
Dirce M.L. Marchioni ◽  
...  

2010 ◽  
Vol 163 (2) ◽  
pp. 339-348 ◽  
Author(s):  
Guri Grimnes ◽  
Bjørg Almaas ◽  
Anne Elise Eggen ◽  
Nina Emaus ◽  
Yngve Figenschau ◽  
...  

ObjectiveBecause we found higher serum 25-hydroxyvitamin D (25(OH)D) levels among smokers than among non-smokers with analyses using an electrochemiluminescence immunoassay (ECLIA) from Roche, the purpose of the present study was to examine whether this difference between smokers and non-smokers was maintained using other serum 25(OH)D assays.DesignA cross-sectional population-based study on 6932 participants from the Tromsø study, 1994–1995, and one validation study comparing six different serum 25(OH)D assays in 53 non-smokers and 54 smokers were performed.MethodsThe association between smoking, season and serum 25(OH)D as measured by ECLIA (Roche) was assessed in the population-based study using general linear models with multivariate adjustments. In the validation study, serum levels of 25(OH)D were analysed with liquid chromatography coupled with mass spectrometry assay from two different laboratories, RIA (DiaSorin), HPLC, RIA (IDS) and ECLIA (Roche). T-tests and linear mixed model analyses were performed to compare the serum 25(OH)D levels in smokers and non-smokers within and between the methods.ResultsIn the population-based study, the serum levels of 25(OH)D using the ECLIA method were 51.9, 53.2 and 72.0 nmol/l in never, former and current smokers (P<0.01). In the validation study, the serum concentration of 25(OH)D was 10.3 nmol/l higher in smokers than in non-smokers (P<0.01) using the ECLIA (Roche), while non-significantly lower serum levels of 25(OH)D were found in smokers using the other five methods.ConclusionsThese two studies indicate that the ECLIA (Roche) overestimates serum 25(OH)D levels in smokers by unknown mechanisms. If confirmed, this might have clinical consequences, and the issue needs further exploration.


2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Kátia Josiany Segheto ◽  
Leidjaira Lopes Juvanhol ◽  
Danielle Cristina Guimarães da Silva ◽  
Cristiane Junqueira de Carvalho ◽  
Fernanda Hansen ◽  
...  

2013 ◽  
Vol 177 (9) ◽  
pp. 894-903 ◽  
Author(s):  
A. M. Brodie ◽  
R. M. Lucas ◽  
S. L. Harrison ◽  
I. A. F. van der Mei ◽  
B. Armstrong ◽  
...  

2010 ◽  
Vol 104 (11) ◽  
pp. 1696-1702 ◽  
Author(s):  
Guixiang Zhao ◽  
Earl S. Ford ◽  
Chaoyang Li ◽  
Lina S. Balluz

Although there is evidence that vitamin D deficiency may play a role in depression, studies done on the associations have yielded mixed results. The present study aimed to examine the associations between serum concentrations of 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) and the presence of depression among US adults. A cross-sectional, population-based sample (including 3916 participants aged ≥ 20 years) from the 2005–6 National Health and Nutrition Examination Survey was used. Participants' depressive symptoms were assessed using the Patient Health Questionnaire-9 diagnostic algorithm. The associations of 25(OH)D and PTH with depression were explored using multivariate logistic regression models. For all the participants, the age-adjusted prevalence was 5·3  (95 % CI 4·3, 6·5) % for having moderate-to-severe depression, 2·3  (95 % CI 1·7, 3·1) % for having major depression and 3·8  (95 % CI 3·0, 4·6) % for having minor depression. Although the age-adjusted prevalence and the unadjusted OR of having moderate-to-severe depression or major depression decreased linearly with increasing quartiles of 25(OH)D (P < 0·05 for trends), no significant associations remained after adjusting for multiple potential confounders such as demographic variables, lifestyle factors and coexistence of a number of chronic conditions. Neither the age-adjusted prevalence nor the OR (unadjusted or adjusted) of having depression differed significantly by the quartiles of PTH. Thus, in contrast to some of the previous findings, the present results did not show significant associations between serum concentrations of 25(OH)D and PTH and the presence of moderate-to-severe depression, major depression or minor depression among US adults. However, these findings need to be further confirmed in future studies.


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