Effect of Cardiovascular and Metabolic Disease on Cognitive Test Performance and Cognitive Change in Older Adults

2012 ◽  
Vol 60 (7) ◽  
pp. 1286-1291 ◽  
Author(s):  
Mirjam Köhler ◽  
Matthias Kliegel ◽  
Hanna Kaduszkiewicz ◽  
Cadja Bachmann ◽  
Birgitt Wiese ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Older Adults ◽  
Test Performance ◽  
Cognitive Change ◽  
Cognitive Test ◽  
Cognitive Test Performance

scholarly journals Association Between Cognitive Test Performance and Subjective Cognitive Decline in a Diverse Cohort of Older Adults

2020 ◽  
Vol 34 (3) ◽  
pp. 198-205 ◽  
Author(s):  
Fabian W. Corlier ◽  
Crystal Shaw ◽  
Eleanor Hayes-Larson ◽  
Dan Mungas ◽  
Sarah Tomaszewski Farias ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Test Performance ◽  
Cognitive Test ◽  
Subjective Cognitive Decline ◽  
Cognitive Test Performance

scholarly journals Preliminary Evidence for an Association Between the Composition of the Gut Microbiome and Cognitive Function in Neurologically Healthy Older Adults

2017 ◽  
Vol 23 (8) ◽  
pp. 700-705 ◽  
Author(s):  
Lisa Manderino ◽  
Ian Carroll ◽  
M. Andrea Azcarate-Peril ◽  
Amber Rochette ◽  
Leslie Heinberg ◽  
...  
Keyword(s):  
Older Adults ◽  
Gut Microbiome ◽  
Test Performance ◽  
Animal Studies ◽  
Preliminary Evidence ◽  
Community Dwelling ◽  
Cognitive Test ◽  
Healthy Older Adults ◽  
Stool Samples ◽  
Cognitive Test Performance

AbstractObjectives: Dysbiosis of the gut microbiome is implicated in numerous human health conditions. Animal studies have linked microbiome disruption to changes in cognitive functioning, although no study has examined this possibility in neurologically healthy older adults. Methods: Participants were 43 community-dwelling older adults (50–85 years) that completed a brief cognitive test battery and provided stool samples for gut microbiome sequencing. Participants performing≥1 SD below normative performance on two or more tests were compared to persons with one or fewer impaired scores. Results: Mann Whitney U tests revealed different distributions of Bacteroidetes (p=.01), Firmicutes (p=.02), Proteobacteria (p=.04), and Verrucomicrobia (p=.003) between Intact and Impaired groups. These phyla were significantly correlated with cognitive test performances, particularly Verrucomicrobia and attention/executive function measures. Conclusions: The current findings suggest that composition of the gut microbiome is associated with cognitive test performance in neurologically healthy older adults. Future studies are needed to confirm these findings and explore possible mechanisms. (JINS, 2017, 23, 700–705)

scholarly journals Exercise Test Performance Reveals Evidence of the Cardiorespiratory Fitness Hypothesis

2017 ◽  
Vol 25 (2) ◽  
pp. 240-246 ◽  
Author(s):  
Sandra A. Billinger ◽  
Eric D. Vidoni ◽  
Jill K. Morris ◽  
John P. Thyfault ◽  
Jeffrey M. Burns
Keyword(s):  
Aerobic Exercise ◽  
Test Performance ◽  
Cognitive Change ◽  
Cognitive Testing ◽  
Cognitive Domain ◽  
Cognitive Test ◽  
Cognitive Responses ◽  
Cognitive Benefit ◽  
Using Data ◽  
Cognitive Test Performance

Positive physiologic and cognitive responses to aerobic exercise have resulted in a proposed cardiorespiratory (CR) fitness hypothesis in which fitness gains drive changes leading to cognitive benefit. The purpose of this study was to directly assess the CR fitness hypothesis. Using data from an aerobic exercise trial, we examined individuals who completed cardiopulmonary and cognitive testing at baseline and 26 weeks. Change in cognitive test performance was not related to CR fitness change (r2 = .06, p = .06). However, in the subset of individuals who gave excellent effort during exercise testing, change in cognitive test performance was related to CR fitness change (r2 = .33, p < .01). This was largely due to change in the cognitive domain of attention (r2 = .36, p < .01). The magnitude of change was not explained by duration of exercise. Our findings support further investigation of the CR fitness hypothesis and mechanisms by which physiologic adaptation may drive cognitive change.

P-112: Previous computer knowledge effect on older adults' computerized cognitive test performance

2007 ◽  
Vol 3 (3S_Part_2) ◽  
pp. S134-S134
Author(s):  
Patricia C. Heyn ◽  
Rosa A. Tang ◽  
Tammie Nakamura ◽  
Robert S. Schwartz
Keyword(s):  
Older Adults ◽  
Test Performance ◽  
Cognitive Test ◽  
Computer Knowledge ◽  
Cognitive Test Performance

scholarly journals P3-540: IMPLICATIONS OF SLEEP DISPARITIES FOR COGNITIVE TEST PERFORMANCE AMONG AFRICAN AMERICAN AND WHITE OLDER ADULTS: PRELIMINARY EVIDENCE FROM TWO WISCONSIN COHORTS

2019 ◽  
Vol 15 ◽  
pp. P1178-P1179
Author(s):  
Megan Zuelsdorff ◽  
Barbara B. Bendlin ◽  
Ozioma C. Okonkwo ◽  
Kate E. Sprecher ◽  
Lindsay R. Clark ◽  
...  
Keyword(s):  
Older Adults ◽  
African American ◽  
Test Performance ◽  
Preliminary Evidence ◽  
Cognitive Test ◽  
Cognitive Test Performance

Functional Connectivity of the Supplementary Motor Network Is Associated with Fried’s Modified Frailty Score in Older Adults

2020 ◽  
Vol 75 (12) ◽  
pp. 2239-2248 ◽  
Author(s):  
Florian Lammers ◽  
Norman Zacharias ◽  
Friedrich Borchers ◽  
Rudolf Mörgeli ◽  
Claudia Doris Spies ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Test Performance ◽  
Elective Surgery ◽  
Clinical Sample ◽  
Cognitive Testing ◽  
Cognitive Test ◽  
Geriatric Syndrome ◽  
Functional Changes ◽  
Cognitive Test Performance

Abstract Frailty is a geriatric syndrome defined by coexistence of unintentional weight loss, low physical reserve, or activity and is associated with adverse health events. Neuroimaging studies reported structural white matter changes in frail patients. In the current study, we hypothesized that clinical frailty is associated also with functional changes in motion-related cortical areas, that is, (pre-)supplementary motor areas (SMA, pre-SMA). We expected that observed functional changes are related to motor-cognitive test performance. We studied a clinical sample of 143 cognitively healthy patients ≥65 years presenting for elective surgery, enrolled in the BioCog prospective multicentric cohort study on postoperative cognitive disorders. Participants underwent preoperative resting-state functional magnetic resonance imaging, motor-cognitive testing, and assessment of Fried’s modified frailty criteria. We analyzed functional connectivity associations with frailty and motor-cognitive test performance. Clinically robust patients (N = 60) showed higher connectivity in the SMA network compared to frail (N = 13) and prefrail (N = 70) patients. No changes were found in the pre-SMA network. SMA connectivity correlated with motor speed (Trail-Making-Test A) and manual dexterity (Grooved Pegboard Test). Our results suggest that diminished functional connectivity of the SMA is an early correlate of functional decline in the older adults . The SMA may serve as a potential treatment target in frailty.

scholarly journals O3-12-04: BLOOD-BASED NEURO-INFLAMMATION BIOMARKERS DIFFERENTIATE PATTERNS OF VASCULAR BRAIN INJURY AND COGNITIVE TEST PERFORMANCE AMONG OLDER ADULTS

2019 ◽  
Vol 15 ◽  
pp. P916-P917
Author(s):  
Joshua C. Bis ◽  
Claudia L. Satizabal ◽  
Bruce M. Psaty ◽  
W.T. Longstreth ◽  
Lenore J. Launer ◽  
...  
Keyword(s):  
Older Adults ◽  
Brain Injury ◽  
Test Performance ◽  
Cognitive Test ◽  
Neuro Inflammation ◽  
Cognitive Test Performance
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