scholarly journals Preliminary Evidence for an Association Between the Composition of the Gut Microbiome and Cognitive Function in Neurologically Healthy Older Adults

2017 ◽  
Vol 23 (8) ◽  
pp. 700-705 ◽  
Author(s):  
Lisa Manderino ◽  
Ian Carroll ◽  
M. Andrea Azcarate-Peril ◽  
Amber Rochette ◽  
Leslie Heinberg ◽  
...  
Keyword(s):  
Older Adults ◽  
Gut Microbiome ◽  
Test Performance ◽  
Animal Studies ◽  
Preliminary Evidence ◽  
Community Dwelling ◽  
Cognitive Test ◽  
Healthy Older Adults ◽  
Stool Samples ◽  
Cognitive Test Performance

AbstractObjectives: Dysbiosis of the gut microbiome is implicated in numerous human health conditions. Animal studies have linked microbiome disruption to changes in cognitive functioning, although no study has examined this possibility in neurologically healthy older adults. Methods: Participants were 43 community-dwelling older adults (50–85 years) that completed a brief cognitive test battery and provided stool samples for gut microbiome sequencing. Participants performing≥1 SD below normative performance on two or more tests were compared to persons with one or fewer impaired scores. Results: Mann Whitney U tests revealed different distributions of Bacteroidetes (p=.01), Firmicutes (p=.02), Proteobacteria (p=.04), and Verrucomicrobia (p=.003) between Intact and Impaired groups. These phyla were significantly correlated with cognitive test performances, particularly Verrucomicrobia and attention/executive function measures. Conclusions: The current findings suggest that composition of the gut microbiome is associated with cognitive test performance in neurologically healthy older adults. Future studies are needed to confirm these findings and explore possible mechanisms. (JINS, 2017, 23, 700–705)

scholarly journals P3-540: IMPLICATIONS OF SLEEP DISPARITIES FOR COGNITIVE TEST PERFORMANCE AMONG AFRICAN AMERICAN AND WHITE OLDER ADULTS: PRELIMINARY EVIDENCE FROM TWO WISCONSIN COHORTS

2019 ◽  
Vol 15 ◽  
pp. P1178-P1179
Author(s):  
Megan Zuelsdorff ◽  
Barbara B. Bendlin ◽  
Ozioma C. Okonkwo ◽  
Kate E. Sprecher ◽  
Lindsay R. Clark ◽  
...  
Keyword(s):  
Older Adults ◽  
African American ◽  
Test Performance ◽  
Preliminary Evidence ◽  
Cognitive Test ◽  
Cognitive Test Performance

scholarly journals Association Between Cognitive Test Performance and Subjective Cognitive Decline in a Diverse Cohort of Older Adults

2020 ◽  
Vol 34 (3) ◽  
pp. 198-205 ◽  
Author(s):  
Fabian W. Corlier ◽  
Crystal Shaw ◽  
Eleanor Hayes-Larson ◽  
Dan Mungas ◽  
Sarah Tomaszewski Farias ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Test Performance ◽  
Cognitive Test ◽  
Subjective Cognitive Decline ◽  
Cognitive Test Performance

P-112: Previous computer knowledge effect on older adults' computerized cognitive test performance

2007 ◽  
Vol 3 (3S_Part_2) ◽  
pp. S134-S134
Author(s):  
Patricia C. Heyn ◽  
Rosa A. Tang ◽  
Tammie Nakamura ◽  
Robert S. Schwartz
Keyword(s):  
Older Adults ◽  
Test Performance ◽  
Cognitive Test ◽  
Computer Knowledge ◽  
Cognitive Test Performance

Functional Connectivity of the Supplementary Motor Network Is Associated with Fried’s Modified Frailty Score in Older Adults

2020 ◽  
Vol 75 (12) ◽  
pp. 2239-2248 ◽  
Author(s):  
Florian Lammers ◽  
Norman Zacharias ◽  
Friedrich Borchers ◽  
Rudolf Mörgeli ◽  
Claudia Doris Spies ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Test Performance ◽  
Elective Surgery ◽  
Clinical Sample ◽  
Cognitive Testing ◽  
Cognitive Test ◽  
Geriatric Syndrome ◽  
Functional Changes ◽  
Cognitive Test Performance

Abstract Frailty is a geriatric syndrome defined by coexistence of unintentional weight loss, low physical reserve, or activity and is associated with adverse health events. Neuroimaging studies reported structural white matter changes in frail patients. In the current study, we hypothesized that clinical frailty is associated also with functional changes in motion-related cortical areas, that is, (pre-)supplementary motor areas (SMA, pre-SMA). We expected that observed functional changes are related to motor-cognitive test performance. We studied a clinical sample of 143 cognitively healthy patients ≥65 years presenting for elective surgery, enrolled in the BioCog prospective multicentric cohort study on postoperative cognitive disorders. Participants underwent preoperative resting-state functional magnetic resonance imaging, motor-cognitive testing, and assessment of Fried’s modified frailty criteria. We analyzed functional connectivity associations with frailty and motor-cognitive test performance. Clinically robust patients (N = 60) showed higher connectivity in the SMA network compared to frail (N = 13) and prefrail (N = 70) patients. No changes were found in the pre-SMA network. SMA connectivity correlated with motor speed (Trail-Making-Test A) and manual dexterity (Grooved Pegboard Test). Our results suggest that diminished functional connectivity of the SMA is an early correlate of functional decline in the older adults . The SMA may serve as a potential treatment target in frailty.

scholarly journals Prognostic Factors and Models for Changes in Cognitive Performance After Multi-Domain Cognitive Training in Healthy Older Adults: A Systematic Review

2021 ◽  
Vol 15 ◽  
Author(s):  
Mandy Roheger ◽  
Hannah Liebermann-Jordanidis ◽  
Fabian Krohm ◽  
Anne Adams ◽  
Elke Kalbe
Keyword(s):  
Older Adults ◽  
Prognostic Factors ◽  
Cognitive Training ◽  
Test Performance ◽  
Reporting Quality ◽  
Cognitive Outcomes ◽  
Cognitive Test ◽  
Future Research ◽  
Healthy Older Adults ◽  
Model Studies

Background: Cognitive Training (CT) may contribute to the maintenance and even enhancement of cognitive functions in healthy older adults. However, the question who benefits most from multi-domain CTs is still highly under-investigated.Objective: The goal is to investigate prognostic factors and models for changes in cognitive test performance in healthy older adults after a multi-domain CT.Methods: The data bases MEDLINE, Web of Science Core Collection, CENTRAL, and PsycInfo were searched up to July 2019. Studies investigating prognostic factors and/or models on cognitive outcomes (global cognition, memory, attention, executive functions, language, visuo-spatial abilities) after conducting a multi-domain CT in healthy older adults were included. Risk of Bias was assessed using the QUIPS and the PROBAST tool.Results: 23 prognostic factor and model studies were included. Results indicate a high heterogeneity regarding the conducted multi-domain CTs, the investigated prognostic factors, the investigated outcomes, and the used statistical approaches. Age and neuropsychological performance at study entry were the most investigated predictors, yet they show inconsistent results.Conclusion: Data on prognostic factors and models of changes after multi-domain CT are still too rare and inconsistent to draw clear conclusions due to statistical shortcomings and low reporting quality. Approaches for future research are outlined.Registration:https://www.crd.york.ac.uk/prospero/, ID: CRD42020147531

scholarly journals O3-12-04: BLOOD-BASED NEURO-INFLAMMATION BIOMARKERS DIFFERENTIATE PATTERNS OF VASCULAR BRAIN INJURY AND COGNITIVE TEST PERFORMANCE AMONG OLDER ADULTS

2019 ◽  
Vol 15 ◽  
pp. P916-P917
Author(s):  
Joshua C. Bis ◽  
Claudia L. Satizabal ◽  
Bruce M. Psaty ◽  
W.T. Longstreth ◽  
Lenore J. Launer ◽  
...  
Keyword(s):  
Older Adults ◽  
Brain Injury ◽  
Test Performance ◽  
Cognitive Test ◽  
Neuro Inflammation ◽  
Cognitive Test Performance

Effect of Cardiovascular and Metabolic Disease on Cognitive Test Performance and Cognitive Change in Older Adults

2012 ◽  
Vol 60 (7) ◽  
pp. 1286-1291 ◽  
Author(s):  
Mirjam Köhler ◽  
Matthias Kliegel ◽  
Hanna Kaduszkiewicz ◽  
Cadja Bachmann ◽  
Birgitt Wiese ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Older Adults ◽  
Test Performance ◽  
Cognitive Change ◽  
Cognitive Test ◽  
Cognitive Test Performance
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