Prognostic Significance of Implantable Defibrillator Shock: Are All Shocks Created Equal?

2012 ◽  
Vol 23 (7) ◽  
pp. 741-743 ◽  
Author(s):  
NAHUM A FREEDBERG ◽  
ALEXANDER FELDMAN
Author(s):  
Selçuk Adabag ◽  
Patrick Zimmerman ◽  
Adam Black ◽  
Mohammad Madjid ◽  
Payam Safavi‐Naeini ◽  
...  

Background COVID‐19 was temporally associated with an increase in out‐of‐hospital cardiac arrests, but the underlying mechanisms are unclear. We sought to determine if patients with implantable defibrillators residing in areas with high COVID‐19 activity experienced an increase in defibrillator shocks during the COVID‐19 outbreak. Methods and Results Using the Medtronic (Mounds View, MN) Carelink database from 2019 and 2020, we retrospectively determined the incidence of implantable defibrillator shock episodes among patients residing in New York City, New Orleans, LA, and Boston, MA. A total of 14 665 patients with a Medtronic implantable defibrillator (age, 66±13 years; and 72% men) were included in the analysis. Comparing analysis time periods coinciding with the COVID‐19 outbreak in 2020 with the same periods in 2019, we observed a larger mean rate of defibrillator shock episodes per 1000 patients in New York City (17.8 versus 11.7, respectively), New Orleans (26.4 versus 13.5, respectively), and Boston (30.9 versus 20.6, respectively) during the COVID‐19 surge. Age‐ and sex‐adjusted hurdle model showed that the Poisson distribution rate of defibrillator shocks for patients with ≥1 shock was 3.11 times larger (95% CI, 1.08–8.99; P =0.036) in New York City, 3.74 times larger (95% CI, 0.88–15.89; P =0.074) in New Orleans, and 1.97 times larger (95% CI, 0.69–5.61; P =0.202) in Boston in 2020 versus 2019. However, the binomial odds of any given patient having a shock episode was not different in 2020 versus 2019. Conclusions Defibrillator shock episodes increased during the higher COVID‐19 activity in New York City, New Orleans, and Boston. These observations may provide insights into COVID‐19–related increase in cardiac arrests.


2018 ◽  
Vol 41 (9) ◽  
pp. 1171-1177 ◽  
Author(s):  
Kazuo Miyazawa ◽  
Yusuke Kondo ◽  
Marehiko Ueda ◽  
Takatsugu Kajiyama ◽  
Masahiro Nakano ◽  
...  

2006 ◽  
Vol 119 (10) ◽  
pp. 892-896 ◽  
Author(s):  
William R. Lewis ◽  
Donna L. Luebke ◽  
Nancy J. Johnson ◽  
Michael D. Harrington ◽  
Ottorino Costantini ◽  
...  

Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.


2007 ◽  
Vol 177 (4S) ◽  
pp. 127-128
Author(s):  
Michael Muntener ◽  
Jonathan I. Epstein ◽  
David J. Hernandez ◽  
Mark L. Gonzalgo ◽  
Leslie A. Mangold ◽  
...  

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