scholarly journals Immune and acute phase response in pigs experimentally infected with H1N2 swine influenza virus

2012 ◽  
Vol 66 (3) ◽  
pp. 334-342 ◽  
Author(s):  
Małgorzata Pomorska-Mól ◽  
Iwona Markowska-Daniel ◽  
Krzysztof Kwit
Keyword(s):  
Influenza Virus ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Phase Response

Cytokines and the acute phase response to influenza virus in mice

1995 ◽  
Vol 268 (1) ◽  
pp. R78-R84 ◽  
Author(s):  
C. A. Conn ◽  
J. L. McClellan ◽  
H. F. Maassab ◽  
C. W. Smitka ◽  
J. A. Majde ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Locomotor Activity ◽  
Acute Phase ◽  
Water Intake ◽  
Acute Phase Response ◽  
Lavage Fluid ◽  
Lung Lavage ◽  
Phase Response ◽  
Necrosis Factor Alpha ◽  
Food And Water Intake

This study characterized selected aspects of the acute phase response after intranasal inoculation of mice with two doses of mouse-adapted influenza virus differing in lethality. Mice given 140 plaque-forming units (PFU) of virus (58% survival) gradually decreased food and water intake to nearly zero over 6 days; survivors then slowly increased intakes. Declines in these behaviors were parallel to decreases in body temperature and general locomotor activity and were associated with elevated activities of interleukin-6 (IL-6), tumor necrosis factor-alpha, and interferons in lung lavage fluid. Circulating levels of these cytokines were not increased. After 55,000 PFU of virus (100% mortality), food and water intake fell to near zero within 48 h, temperature and locomotor activity decreased significantly, and activities of IL-1 and IL-6 were elevated in lung lavage fluid. These data show that cytokine activities in the lungs are elevated in a time frame that supports the hypothesis that cytokines could mediate behavioral and physiological changes in mice during acute influenza infections.

scholarly journals Correlation Between Serum Acute Phase Proteins, Lung Pathology, and Disease Severity in Pigs Experimentally Co-Infected with H3N2 Swine Influenza Virus and Bordetella Bronchiseptica

2015 ◽  
Vol 59 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Małgorzata Pomorska-Mól ◽  
Iwona Markowska-Daniel ◽  
Krzysztof Kwit ◽  
Kinga Urbaniak ◽  
Zygmunt Pejsak
Keyword(s):  
Influenza Virus ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Clinical Score ◽  
Bordetella Bronchiseptica ◽  
Lung Pathology ◽  
Serum Samples ◽  
Amyloid A

Abstract The kinetics of C-reactive protein (CRP), haptoglobin (Hp), serum amyloid A (SAA), and pig major acute protein (Pig-MAP) response in pigs co-infected with H3N2 swine influenza virus (SwH3N2) and Bordetella bronchiseptica (Bbr) was studied, with assessment of potential correlations between the concentration of acute phase proteins (APPs) in serum samples, lung lesions, and the clinical course of the disease in co-infected pigs. The standard bacteriological methods for detection of Bbr and PCR technique for identification of Bbr and SwH3N2 were used. The serum concentrations of APPs were measured using ELISA. The concentration of CRP, SAA, and Pig-MAP was significantly higher from 2 to 4 or 5 dpi. The concentration of Hp was elevated until the end of the study. Significant correlations were found between the serum concentration of SAA and Pig-MAP and clinical score, and between the concentration of SAA and lung score. Apart from their potential as biological markers for co-infections, SAA and Pig-MAP levels have additive value since they are related to the severity of infection. The results indicate that measurement of APP (i.e SAA) may prove valuable in assessing the severity of respiratory infection in pigs, and may be of supportive value in the clinical evaluation of animals and in the selection of more appropriate treatment.

Influenza virus-induced changes in rabbit sleep and acute phase responses

1992 ◽  
Vol 263 (5) ◽  
pp. R1115-R1121 ◽  
Author(s):  
M. Kimura-Takeuchi ◽  
J. A. Majde ◽  
L. A. Toth ◽  
J. M. Krueger
Keyword(s):  
Influenza Virus ◽  
Antiviral Activity ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Defense Mechanisms ◽  
Brain Temperature ◽  
Allantoic Fluid ◽  
Serum Levels ◽  
Phase Response ◽  
Serum Ceruloplasmin

Systematic investigations of sleep after viral inoculation have not previously been described. In the present study, rabbits were inoculated intravenously (iv) with control allantoic fluid followed by two sequential inoculations of influenza virus at intervals of 24 h. After each i.v. inoculation, sleep and brain temperature (Tbr), as well as leukocyte distributions and serum levels of antiviral activity and ceruloplasmin, were monitored. The first viral inoculation elicited several acute phase responses, including increased non-rapid-eye-movement sleep (NREMS), Tbr, serum antiviral activity, and serum ceruloplasmin levels, as well as neutrophilia and lymphopenia. In contrast to the effects of the first inoculation, after the second inoculation of virus, all these acute phase parameters were diminished or absent (the hyporesponsive state). Inoculation of naive rabbits with heat-inactivated virus was similarly ineffective; however, inoculation of this group of rabbits with viable virus 24 h later did induce full-scale acute phase responses. The possible role of cytokines in mediating the acute phase response after influenza viral challenge is discussed. Results support the hypothesis that sleep is a facet of the acute phase response involved in host defense mechanisms.

Profile of the porcine acute-phase proteins response following experimental co-infection with H3N2 swine influenza virus andPasteurella multocida

Biomarkers ◽  
2015 ◽  
Vol 20 (3) ◽  
pp. 189-195 ◽  
Author(s):  
Małgorzata Pomorska-Mól ◽  
Iwona Markowska-Daniel ◽  
Krzysztof Kwit ◽  
Katarzyna Stępniewska ◽  
Zygmunt Pejsak
Keyword(s):  
Influenza Virus ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Swine Influenza Virus ◽  
Swine Influenza
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