A comparison of the mental status, personality profiles and life events of patients with irritable bowel syndrome and peptic ulcer disease

Backgrounds: Helicobacter Pylori is a common pathogen leading cause of peptic ulcer disease. Several studies linked Helicobacter Pylori infection and the development of irritable bowel syndrome. Aims: We investigated the effectiveness of standard triple therapy and the association between H.Pylori infection and the development of post infectious irritable bowel syndrome. Materials and methods: Prospective analytical study was conducted and we appointed 200 H.Pylori positive patients, they consented and subjected to structured questionnaire and received standard triple therapy (14 days course of proton pump inhibitor (PPI), clarithromycin and either amoxicillin or metronidazole). After three months all patients re-evaluated regarding their symptoms and tested for eradication. Additionally we evaluated the association between H.Pylori infection and irritable bowel syndrome

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Life events stress and psychosocial factors in men with peptic ulcer disease

Gastroenterology ◽

10.1016/0016-5085(86)90189-7 ◽

1986 ◽

Vol 91 (6) ◽

pp. 1370-1379 ◽

Cited By ~ 94

Author(s):

Mark Feldman ◽

Pamela Walker ◽

Janet L. Green ◽

Kathy Weingarden

Keyword(s):

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Psychosocial Factors ◽

Life Events ◽

Ulcer Disease

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Peptic Ulcer Disease and Misuses of Ulcer Healing Drugs in a Tertiary Care Hospital in Dhaka City

Journal of Medicine ◽

10.3329/jom.v16i1.22386 ◽

2015 ◽

Vol 16 (1) ◽

pp. 27-34

Author(s):

Md. Hafiz Md. Hafiz Sardar ◽

Mohammad Murad Hossain ◽

Khan Abul Kalam Azad ◽

Md Uzzwal Mallik ◽

Moumita Chakraborty

Keyword(s):

Peptic Ulcer ◽

Abdominal Pain ◽

Peptic Ulcer Disease ◽

College Hospital ◽

Female Ratio ◽

Ulcer Disease ◽

Medical College ◽

Non Ulcer Dyspepsia ◽

Irritable Bowel ◽

Upper Abdominal

This prospective cross sectional study was conducted in Dhaka Medical College Hospital, Dhaka during July, 2013 to December, 2013. Hundred patients were included in this study. Peptic ulcer disease, presented as upper abdominal pain is one of the common disease with a number of underlying causes. Prospective analyses of 100 patients with upper abdominal pain were studied at medicine units of Dhaka Medical College Hospital, Dhaka. Of these 36 patients belonged to peptic ulcer, 20 patients to irritable bowel syndrome and 22 patients to non-ulcer dyspepsia. Next in order were helminthiasis (5 patients), cholelithiasis (4 patients), gastric carcinoma (4 patients), liver abscess (5 patients) chronic pancreatitis (3 patients) and acute pancreatitis (1 patient). Mean age incidence in this series was 39.47 years. Male and female ratio was 1.54:1. Forty patients were smoker with male and female ratio of 3.44:1.All patients had presenting feature of upper abdominal pain. Commonest site of pain was in the epigastrium in 48.08% of cases.Pain was burning in 43.27% cases, periodic pain in 24.03%, and nocturnal hunger pain in 33.65% of cases.Relief of pain after taking food were observed in 38.46%. Epigastric tenderness was present in 56.73% patients.The diagnosis of peptic ulcer disease, irritable bowel syndrome and non-ulcer dyspepsia, the three leading causes of upper abdominal pain, were suspected by history and physical examination but it was difficult to interpret these on clinical ground alone .Some routine and some selected investigation were done for confirmatory diagnosis.In this series, significant disparity detected between clinically diagnosed peptic ulcer diseases 90.38% and endoscopically confirmed peptic ulcer disease, 34.62% cases. As a consequence of wrong diagnosis of PUD, there are huge misuses of ulcer healing drugs and a great economic burden on patients (300 taka per month) and on the nation.DOI: http://dx.doi.org/10.3329/jom.v16i1.22386 J MEDICINE 2015; 16 : 27-34

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Life events stress and psychosocial factors in men with peptic ulcer disease

Gastroenterology ◽

10.1016/0016-5085(88)90419-2 ◽

1988 ◽

Vol 94 (2) ◽

pp. 323-330 ◽

Cited By ~ 53

Author(s):

Pamela Walker ◽

Janet Luther ◽

I.Michael Samloff ◽

Mark Feldman

Keyword(s):

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Psychosocial Factors ◽

Life Events ◽

Ulcer Disease

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GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

Nature Communications ◽

10.1038/s41467-021-21280-7 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Yeda Wu ◽

Graham K. Murray ◽

Enda M. Byrne ◽

Julia Sidorenko ◽

Peter M. Visscher ◽

...

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Genome Wide Association Study ◽

Gastrointestinal Diseases ◽

Ulcer Disease ◽

Susceptibility To Infection ◽

Genome Wide ◽

Host Genetic ◽

Irritable Bowel

AbstractGenetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Here, genome-wide association study (GWAS) analyses based on 456,327 UK Biobank (UKB) individuals identify 8 independent and significant loci for PUD at, or near, genes MUC1, MUC6, FUT2, PSCA, ABO, CDX2, GAST and CCKBR. There are previously established roles in susceptibility to Helicobacter pylori infection, response to counteract infection-related damage, gastric acid secretion or gastrointestinal motility for these genes. Only two associations have been previously reported for duodenal ulcer, here replicated trans-ancestrally. The results highlight the role of host genetic susceptibility to infection. Post-GWAS analyses for PUD, GORD, IBS and IBD add insights into relationships between these gastrointestinal diseases and their relationships with depression, a commonly comorbid disorder.

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