Combined photocontact dermatitis to benzydamine hydrochloride and the emulsifiers, Span 60 and Tween 60 contained in Tantum�cream

2007 ◽  
Vol 57 (1) ◽  
pp. 61-62 ◽  
Author(s):  
Ana Giménez-Arnau ◽  
Montserrat Gilaberte ◽  
David Conde ◽  
Merce Espona ◽  
Ramon M. Pujol
Keyword(s):  
Tween 60 ◽  
Span 60

scholarly journals Streptomycin Sulfate–Loaded Niosomes Enables Increased Antimicrobial and Anti-Biofilm Activities

2021 ◽  
Vol 9 ◽  
Author(s):  
Maryam Mansouri ◽  
Nazanin Khayam ◽  
Elham Jamshidifar ◽  
Tara Pourseif ◽  
Sepideh Kianian ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Free Drug ◽  
Cholesterol Ratio ◽  
Streptomycin Sulfate ◽  
Human Foreskin Fibroblasts ◽  
Optimum Formulation ◽  
Low Toxicity ◽  
Direct Delivery ◽  
Tween 60 ◽  
Span 60

One of the antibiotics used to treat infections is streptomycin sulfate that inhibits both Gram-negative and -positive bacteria. Nanoparticles are suitable carriers for the direct delivery and release of drug agents to infected locations. Niosomes are one of the new drug delivery systems that have received much attention today due to their excellent biofilm penetration property and controlled release. In this study, niosomes containing streptomycin sulfate were prepared by using the thin layer hydration method and optimized based on the size, polydispersity index (PDI), and encapsulation efficiency (EE%) characteristics. It was found that the Span 60-to-Tween 60 ratio of 1.5 and the surfactant-to-cholesterol ratio of 1.02 led to an optimum formulation with a minimum of size, low PDI, and maximum of EE of 97.8 nm, 0.27, and 86.7%, respectively. The drug release investigation showed that 50.0 ± 1.2% of streptomycin sulfate was released from the niosome in 24 h and reached 66.4 ± 1.3% by the end of 72 h. Two-month stability studies at 25° and 4°C showed more acceptable stability of samples kept at 4°C. Consequently, antimicrobial and anti-biofilm activities of streptomycin sulfate–loaded niosomes against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa were found significantly higher than those of free drug, and the minimum inhibitory concentration values decreased 4- to 8-fold. Furthermore, niosome-encapsulated streptomycin up to 1,500 μg/ml exhibited negligible cytotoxicity against the human foreskin fibroblasts cell line, whereas the free drug exhibited slight cytotoxicity at this concentration. Desired physical characteristics and low toxicity of niosomal nano-carriers containing streptomycin sulfate made them a demanded candidate for the treatment of current bacterial infections and biofilms.

scholarly journals FORMULASI SEDIAAN LOTION SARI KERING HERBA PEGAGAN (Centella asiatica(L.) URBAN ) DENGAN VARIASI KONSENTRASI EMULGATOR SPAN 60 DAN TWEEN 60

Media Farmasi ◽  
2020 ◽  
Vol 16 (1) ◽  
pp. 1
Author(s):  
Arisanty Arisanty ◽  
Santi Sinala ◽  
Muli Sukmawaty ◽  
Andi Masna
Keyword(s):  
Centella Asiatica ◽  
Physical Quality ◽  
Accelerated Storage ◽  
Before And After ◽  
Quality Stability ◽  
Dispersion Test ◽  
The Stability ◽  
Tween 60 ◽  
Span 60

Gotu Kola (Centella asiatica (L.) Urb) is a plant widely grown and scientifically proven to be an antioxidant. This study makes a lotion formula containing dried Gotu kola herb with varying concentrations of emulgator span 60 and tween 60. It determines the concentration of span 60 and tween 60, producing lotions with the most stable physical quality and accelerated storage methods. The lotion was prepared using a concentration of Centellaasiatica (L.) Herbaceous Dry Herb extract of 1% and an Emulgator span 60 and tween 60 in a concentration variation of 5%, 7.5%, and 10%. The stability of the lotion was determined based on quality observations. The physical condition before and after the storage is accelerated for six cycles at a temperature of 5oC and 35oC in organoleptic, homogeneous, pH, viscosity, diffusion power, and emulsion type. The research results show the physical quality stability of formula I (5% emulgator) did not meet the requirements of the dispersion test before storage was accelerated. In contrast, the formula with a 7.5% emulgator met the physical quality requirements of the preparation before and after storage was accelerated. Additionally, the 10% emulgator did not meet the requirements of the dispersion test after accelerated storage. The type of emulsion in all three formulas is the M / A type. The most stable physical quality of the three preparations is a formula with a 7.5% emulgator.Keywords: Lotion, Gotu kola (Centella asiatica (L.) Urb), physical quality, span, and tween.Pegagan (Centella asiatica(L.)Urb) merupakan tanaman yang banyak tumbuh di Indonesia dan telah terbukti secara ilmiah memiliki kemampuan sebagai antioksidan. Penelitian ini bertujuan  untuk membuat formula lotion yang  mengandung sari kering herba pegagan (Centella asiatica(L.) Urban) dengan variasi konsentrasi emulgator span 60 dan tween 60, dan untuk mengetahui konsetrasi span 60 dan tween 60 yang menghasilkan lotion dengan mutu fisik yang paling stabil dengan metode penyimpanan dipercepat. Sediaan dibuat lotion dengan konsentrasi sari Kering Herba  Pegagan (Centellaasiatica(L.) Urban ) sebesar 1% dan Emulgator span 60 serta tween 60 dengan variasi konsentrasi 5%, 7,5%, dan 10% kemudian stabilitas sedian lotion ditentukan berdasarkan pengamatan mutu fisik sebelum dans sesudah penyimpanan dipercepat selama 6 siklus pada suhu 5oCdan 35oC yang meliputi organeleptis, homogentias, pH, viskositas, daya sebar, dan tipe emulsi. Hasil penelitian pada pengujian kestabilan mutu fisik formula I (emulgator 5%) tidak memenuhi syarat pada uji daya sebar sebelum penyimpanan dipercepat, sedangkan Formula dengan emulgator 7,5% memenuhi persyaratan mutu fisik sediaan sebelum maupun sesudah penyimpanan dipercepat, dan formula dengan emulgator 10% tidak memenuhi syarat pada uji daya sebar setelah penyimpanan dipercepat, untuk tipe emulsi pada ketiga formula tersebut merupakan tipe emulsiM/A. Mutu fisik yang paling stabil dari ketiga sediaan tersebut adalah formula dengan emulgator 7,5%.Kata kunci : Lotion,  herba pegagan (Centella asiatica (L.) Urb), mutu fisik, span dan tween.

scholarly journals PHYSICAL PROPERTIES AND RATE OF DIFFUSION TRANSETHOSOME CURCUMIN USING A COMBINATION OF TWEEN 60 AND SPAN 60 AS SURFACTANT

2021 ◽  
pp. 66-70
Author(s):  
ANISA AMALIA ◽  
YUDI SRIFIANA ◽  
AMALIA ANWAR
Keyword(s):  
Particle Size ◽  
Physical Properties ◽  
Diffusion Rate ◽  
Entrapment Efficiency ◽  
Zero Order Kinetics ◽  
Significant Difference ◽  
Tween 60 ◽  
Span 60

Objective: Curcumin penetration can be increased by formulating it into the transethosome system. Surfactant is one of the transethosome components that affect the physical properties and penetration of vesicles. In this study, a combination of two surfactants was used to see the effect of surfactants on physical properties and curcumin penetration. Methods: This study used a combination of tween 60 and span 60 with a concentration ratio of 0:5 (F1), 1:1 (F2), 2:1 (F3), and 1:2 (F4). An evaluation included testing the distribution of particle size, zeta potential, and entrapment efficiency in the system. Evaluation continued with the determination of the diffusion rate in vitro.  Results: The transethosome system formed has a particle size of 167.9±4.7 nm-396±3.7 nm with a potential zeta value (-) 49.54±1.77 mV-(-) 59.05±0.95 mV, polydispersion index 0.0%-57.1% and entrapment efficiency of 83.76%-93.75%. The diffusion rate of F1 and F3 followed the Higuchi kinetics model, while F2 and F4 followed zero-order kinetics and the Korsmeyer-Peppas kinetics. Conclusion: The combination of tween 60 and span 60 could form a nano-sized transethosome of curcumin. Diffusion rate testing results show that using a surfactant combination can increase the diffusion rate of curcumin, where there is a significant difference between each formula (p<0.05).

scholarly journals Study of the stability of lipid nanoemulsions with oleic acid

2021 ◽  
Vol 12 (2-2021) ◽  
pp. 174-176
Author(s):  
E. V. Mishchenko ◽  
◽  
E. E. Timofeeva ◽  
A. S. Artamonov ◽  
M. Yu. Koroleva ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Phase Inversion ◽  
Nonionic Surfactants ◽  
Inversion Method ◽  
Ionic Surfactant ◽  
Temperature Phase ◽  
The Stability ◽  
Tween 60 ◽  
Span 60 ◽  
Phase Inversion Method

This work presents the results of a study on the effect of ionic surfactant cetriltrimethylammonium chloride (CTAB) on the size and ζ-potential of lipid nanoemulsions composed of oleic acid, prepared by temperature phase inversion method and stabilized by nonionic surfactants — Tween 60, Span 60

scholarly journals Solid lipid nanoparticles with stearic acid stabilized with yttrium stearate

2021 ◽  
Vol 12 (2-2021) ◽  
pp. 282-284
Author(s):  
A. D. Shirokikh ◽  
◽  
M. Y. Koroleva ◽  
E. V. Yurtov ◽  
◽  
...  
Keyword(s):  
Stearic Acid ◽  
Physicochemical Properties ◽  
Solid Lipid Nanoparticles ◽  
Nonionic Surfactants ◽  
Lipid Nanoparticles ◽  
Single Particles ◽  
Solid Lipid ◽  
Tween 60 ◽  
Span 60 ◽  
Average Size

In this work, we studied the effect of yttrium stearate on the physicochemical properties of dispersions of solid lipid nanoparticles composed of stearic acid stabilized with nonionic surfactants (Tween 60, Span 60). The results showed that an increase in the concentration of yttrium stearate leads to increasing kinetic stability and decreasing the average size of the aggregates. Along with this, the average size of single particles remains practically unchanged and amounts to 35±5 nm.

scholarly journals pH-responsive cisplatin-loaded niosomes: synthesis, characterization, cytotoxicity study and interaction analyses by simulation methodology

2020 ◽  
Vol 6 (1) ◽  
pp. 1-15
Author(s):  
Saman Sargazi ◽  
Seyedeh Maryam Hosseinikhah ◽  
Farshid Zargari ◽  
Narendra Pal Singh Chauhana ◽  
Mohadeseh Hassanisaadi ◽  
...  
Keyword(s):  
Cancer Cell Line ◽  
Lethal Effect ◽  
Ionic Surfactant ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Anticancer Drug Delivery ◽  
Cholesteryl Hemisuccinate ◽  
Tween 60 ◽  
Span 60 ◽  
In Cis

Abstract Cisplatin (Cis) is an effective cytotoxic agent, but its administration has been challenged by kidney problems, reduced immunity system, chronic neurotoxicity, and hemorrhage. To address these issues, pH-responsive non-ionic surfactant vesicles (niosomes) by Span 60 and Tween 60 derivatized by cholesteryl hemisuccinate (CHEMS), a pH-responsive agent, and Ergosterol (helper lipid), were developed for the first time to deliver Cis. The drug was encapsulated in the niosomes with a high encapsulation efficiency of 89%. This system provided a responsive release of Cis in pH 5.4 and 7.4, thereby improving its targeted anticancer drug delivery. The noisome bilayer model was studied by molecular dynamic simulation containing Tween 60, Span 60, Ergosterol, and Cis molecules to understand the interactions between the loaded drug and noisome constituents. We found that the platinum and chlorine atoms in Cis are critical factors in distributing the drug between water and bilayer surface. Finally, the lethal effect of niosomal Cis was investigated on the MCF7 breast cancer cell line using 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results from morphology monitoring and cytotoxic assessments suggested a better cell-killing effect for niosomal Cis than standard Cis. Together, the synthesis of stimuli-responsive niosomes could represent a promising delivery strategy for anticancer drugs.

scholarly journals Evaluation of sonication on stability-indicating properties of optimized pilocarpine hydrochloride-loaded niosomes in ocular drug delivery

2021 ◽  
Author(s):  
K. Owodeha-Ashaka ◽  
M. Ilomuanya ◽  
A. Iyire
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Entrapment Efficiency ◽  
Process Variable ◽  
Hydrophilic Drugs ◽  
Stability Indicating ◽  
Long Term Stability ◽  
Tween 60 ◽  
Span 60 ◽  
Sonication Parameters

AbstractNiosomes are increasingly explored for enhancing drug penetration and retention in ocular tissues for both posterior and anterior eye delivery. They have been employed in encapsulating both hydrophilic and hydrophobic drugs, but their use is still plagued with challenges of stability and poor entrapment efficiency particularly with hydrophilic drugs. As a result, focus is on understanding the parameters that affect their stability and their optimization for improved results. Pilocarpine hydrochloride (HCl), a hydrophilic drug is used in the management of intraocular pressure in glaucoma. We aimed at optimizing pilocarpine HCl niosomes and evaluating the effect of sonication on its stability-indicating properties such as particle size, polydispersity index (PDI), zeta potential and entrapment efficiency. Pilocarpine niosomes were prepared by ether injection method. Composition concentrations were varied and the effects of these variations on niosomal properties were evaluated. The effects of sonication on niosomes were determined by sonicating optimized drug-loaded formulations for 30 min and 60 min. Tween 60 was confirmed to be more suitable over Span 60 for encapsulating hydrophilic drugs, resulting in the highest entrapment efficiency (EE) and better polydispersity and particle size indices. Optimum sonication duration as a process variable was determined to be 30 min which increased EE from 24.5% to 42% and zeta potential from (−)14.39 ± 8.55 mV to (−)18.92 ± 7.53 mV. In addition to selecting the appropriate surfactants and varying product composition concentrations, optimizing sonication parameters can be used to fine-tune niosomal properties to those most desirable for extended eye retainment and maintenance of long term stability.

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