Expresion of cell adhesion molecule CD44 in primary tumors of the liver: an immunohistochemical study

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding nectin cell adhesion molecule 3, NECTIN3, when comparing primary tumors of the breast to the tissue of origin, the normal breast. NECTIN3 was also differentially expressed in the brain metastases of patients with metastatic breast cancer. NECTIN3 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of NECTIN3 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. NECTIN3 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

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The level of some blood serum inflammatory factors in depending on the morphological features of the primary tumor of of cervical cancer

Advances in molecular oncology ◽

10.17650/2313-805x-2019-6-3-49-56 ◽

2019 ◽

Vol 6 (3) ◽

pp. 49-56

Author(s):

E. V. Kayukova ◽

T. E. Belokrinitskaya ◽

L. F. Sholokhov ◽

P. P. Tereshkov

Keyword(s):

Cervical Cancer ◽

Cell Adhesion ◽

Blood Serum ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Inflammatory Factors ◽

Primary Tumors ◽

Amyloid A ◽

Markers Of Inflammation ◽

Serum Amyloid A Protein

Background. Tumors influence on various vital processes in organism leading to cachexia, immunosuppression, anemia, changes in humoral regulation etc. Inflammation is one of the well-known etiological factors of carcinogenesis, including for cervical cancer, so we suggest that some blood serum inflammatory factors in patients with cervical cancer influence are associated with the level of tumor progression.The objective of our study was to analyze the level of some hematological markers of inflammation in the blood serum of patients with cervical cancer in dependence on the histological characteristics of the primary tumors.Materials and methods. In the study we analyzed the blood serum of patients with invasive cervical cancer I–IV stage (4 patients with verrucous cancer and 26 – with cervical cancer among them 10 – of G1 stage, 6 – of G2 stage, 10 – G3 stage) using flow cytometry. We studied the value of myoglobin, calprotectin, lipocalin, matrix metalloperoxidase 2, matrix metalloperoxidase 9, osteopontin, myeloperoxidase, serum amyloid A, protein 4, insulin-like growth factor-binding protein 4, cell-cell adhesion molecule 1, vascular cell adhesion molecule, cystatin С.Results. We revealed the changes of some serum markers of inflammation in patients with G3 and verrocous cervical cancer.Conclusion. The obtained dates demonstrate that further study of blood inflammatory markers as an additional differential and prognostic criteria in patients with cervical cancer should be considered as reasonable.

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