Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-β1: role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways

2006 ◽  
Vol 41 (5) ◽  
pp. 418-425 ◽  
Author(s):  
Patricio C. Smith ◽  
Monica Caceres ◽  
Jorge Martinez
Keyword(s):  
Growth Factor ◽  
Signaling Pathways ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Kinase Signaling

scholarly journals High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-β1 Signaling Pathway

2016 ◽  
Vol 22 (1) ◽  
pp. 40-50 ◽  
Author(s):  
Corina-Adriana Ghebes ◽  
Jéré van Lente ◽  
Janine Nicole Post ◽  
Daniel B. F. Saris ◽  
Hugo Fernandes
Keyword(s):  
Growth Factor ◽  
Small Molecules ◽  
Signaling Pathways ◽  
High Throughput Screening ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Bone Morphogenetic Protein 2 ◽  
Screening Assay ◽  
High Throughput Screening Assay ◽  
Tgf Β1

Modulating the bone morphogenetic protein 2 (BMP-2) and transforming growth factor–β1 (TGF-β1) signaling pathways is essential during tendon/ligament (T/L) healing. Unfortunately, growth factor delivery in situ is far from trivial and, in many cases, the necessary growth factors are not approved for clinical use. Here we used a BMP-2 and a TGF-β1 reporter cell line to screen a library of 1280 Food and Drug Administration–approved small molecules and identify modulators of both signaling pathways. We identified four compounds capable of modulating BMP and TGF signaling on primary human tendon–derived cells (huTCs) and describe their effects on proliferation and differentiation of these cells.

Role of tissue transforming growth factor-β1 in pancreatic fibrosis

1998 ◽  
Vol 114 ◽  
pp. A498 ◽  
Author(s):  
M. Shiozaki ◽  
Y. Takeda ◽  
H. Morikawa ◽  
Y. Nakagawa ◽  
K. Katsu
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Pancreatic Fibrosis

scholarly journals The Role of Transforming Growth Factor-β1 in Airway Inflammation of Childhood Asthma

2013 ◽  
Vol 26 (3) ◽  
pp. 725-738 ◽  
Author(s):  
R. Gagliardo ◽  
P. Chanez ◽  
M. Gjomarkaj ◽  
S. La Grutta ◽  
A. Bonanno ◽  
...  
Keyword(s):  
Growth Factor ◽  
Airway Inflammation ◽  
Childhood Asthma ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1
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