Chemically modified tetracyclines stimulate matrix metalloproteinase-2 production by periodontal ligament cells

2006 ◽  
Vol 41 (5) ◽  
pp. 463-470 ◽  
Author(s):  
M. M. Bildt ◽  
A. M. P. Snoek-Van Beurden ◽  
J. DeGroot ◽  
B. Van El ◽  
A. M. Kuijpers-Jagtman ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Periodontal Ligament ◽  
Matrix Metalloproteinase 2 ◽  
Periodontal Ligament Cells ◽  
Chemically Modified ◽  
Chemically Modified Tetracyclines

Bullet for periodontal disease in future: Chemically modified tetracyclines

2021 ◽  
pp. 1-7
Author(s):  
Shivani Sachdeva ◽  
Ameet Mani ◽  
Harish Saluja
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Ligament ◽  
Host Response ◽  
Alveolar Bone ◽  
Gastrointestinal Toxicity ◽  
Collagenolytic Activity ◽  
Periodontal Pathogens ◽  
Oral Biofilm ◽  
Chemically Modified ◽  
Chemically Modified Tetracyclines

Chronic periodontitis is nowadays popularly regarded as Dysbiosis, [1] which causes destruction of tissues rich in collagen like periodontal ligament, alveolar bone and gingival connective tissue. The oral biofilm comprises many periodontal pathogens better regarded as ‘triggers’ in causing chronic periodontitis. Since, not everyone will be affected in the same manner due to periodontal pathogens. Some might not elicit a host response while, the others might have exaggerated response. So, host modulation therapy came into existence to counteract the exaggerated host response. The chemically modified tetracyclines (CMTs) have emerged to inhibit the inflammatory response or to reduce the collagenolytic activity of host. Though a derivative of tetracyclines, it still lacks an antimicrobial action and hence, can be used for periodontitis for longer duration with no adverse effects of gastrointestinal toxicity which parent tetracyclines have.

Enhanced compatibility of chemically modified titanium surface with periodontal ligament cells

2012 ◽  
Vol 262 ◽  
pp. 240-247 ◽  
Author(s):  
T. Kado ◽  
T. Hidaka ◽  
H. Aita ◽  
K. Endo ◽  
Y. Furuichi
Keyword(s):  
Periodontal Ligament ◽  
Titanium Surface ◽  
Periodontal Ligament Cells ◽  
Chemically Modified
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