Intravenous Immunoglobulin Treatment Increased Live Birth Rate in a Spanish Cohort of Women with Recurrent Reproductive Failure and Expanded CD56+ Cells

2012 ◽  
Vol 68 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Manuela Moraru ◽  
Javier Carbone ◽  
Diana Alecsandru ◽  
Marcela Castillo-Rama ◽  
Aurea García-Segovia ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Reproductive Failure ◽  
Immunoglobulin Treatment ◽  
Spanish Cohort

scholarly journals A High Dose Intravenous Immunoglobulin Therapy for Women with Four or More Recurrent Spontaneous Abortions

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Hideto Yamada ◽  
Masamitsu Takeda ◽  
Yoko Maezawa ◽  
Yasuhiko Ebina ◽  
Ryoichi Hazama ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Spontaneous Abortion ◽  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Abnormal Chromosome ◽  
High Dose ◽  
Spontaneous Abortions ◽  
Intravenous Immunoglobulin Therapy ◽  
Chromosome Karyotype

Recurrent spontaneous abortion (RSA) may have immunological etiology. The aim of this study was to assess the efficacy of a high dose intravenous immunoglobulin (HIVIg) therapy, in which 20 g of intact type immunoglobulin was infused daily for 5 days during early gestation, for women who had a history of four or more consecutive spontaneous abortions of unexplained etiology. A total of 60 pregnant RSA women underwent HIVIg therapy, and the pregnancy outcome was assessed. The live birth rate was 73.3% (44/60). Fifteen pregnancies ended in spontaneous abortion, and one ended in intrauterine fetal death. In 11 of the 15 spontaneous abortions, fetuses had abnormal chromosome karyotype. When the 11 pregnancies with abnormal chromosome karyotype were excluded, the live birth rate was as high as 89.8% (44/49). The HIVIg therapy may be effective for severe cases of unexplained RSA.

Sign in / Sign up

Export Citation Format

Share Document