scholarly journals Plasmacytoid Dendritic Cell Precursors Induce Allogeneic T-Cell Hyporesponsiveness and Prolong Heart Graft Survival

2005 ◽  
Vol 5 (8) ◽  
pp. 1808-1819 ◽  
Author(s):  
Masanori Abe ◽  
Zhiliang Wang ◽  
An de Creus ◽  
Angus W. Thomson
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Graft Survival ◽  
Plasmacytoid Dendritic Cell ◽  
Heart Graft

scholarly journals Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual

Immunity ◽  
2010 ◽  
Vol 33 (6) ◽  
pp. 955-966 ◽  
Author(s):  
Melissa Swiecki ◽  
Susan Gilfillan ◽  
William Vermi ◽  
Yaming Wang ◽  
Marco Colonna
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Cd8 T Cell ◽  
Cell Ablation ◽  
Interferon Responses

scholarly journals Viral infection prevents diabetes by inducing regulatory T cells through NKT cell–plasmacytoid dendritic cell interplay

2011 ◽  
Vol 208 (4) ◽  
pp. 729-745 ◽  
Author(s):  
Julien Diana ◽  
Vedran Brezar ◽  
Lucie Beaudoin ◽  
Marc Dalod ◽  
Andrew Mellor ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Regulatory T Cells ◽  
Viral Infection ◽  
Pancreatic Islets ◽  
Viral Infections ◽  
Plasmacytoid Dendritic Cell ◽  
Inkt Cells ◽  
Pancreatic Lymph Nodes

Type 1 diabetes (T1D) is an autoimmune disease resulting from T cell–mediated destruction of insulin-producing β cells, and viral infections can prevent the onset of disease. Invariant natural killer T cells (iNKT cells) exert a regulatory role in T1D by inhibiting autoimmune T cell responses. As iNKT cell–plasmacytoid dendritic cell (pDC) cooperation controls viral replication in the pancreatic islets, we investigated whether this cellular cross talk could interfere with T1D development during viral infection. Using both virus-induced and spontaneous mouse models of T1D, we show that upon viral infection, iNKT cells induce TGF-β–producing pDCs in the pancreatic lymph nodes (LNs). These tolerogenic pDCs convert naive anti-islet T cells into Foxp3+ CD4+ regulatory T cells (T reg cells) in pancreatic LNs. T reg cells are then recruited into the pancreatic islets where they produce TGF-β, which dampens the activity of viral- and islet-specific CD8+ T cells, thereby preventing T1D development in both T1D models. These findings reveal a crucial cooperation between iNKT cells, pDCs, and T reg cells for prevention of T1D by viral infection.

Similar changes in plasmacytoid dendritic cell and CD4 T-cell counts during primary HIV-1 infection and treatment

AIDS ◽  
2006 ◽  
Vol 20 (9) ◽  
pp. 1247-1252 ◽  
Author(s):  
M Scott Killian ◽  
Sue H Fujimura ◽  
Frederick M Hecht ◽  
Jay A Levy
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Cd4 T Cell ◽  
Cell Counts ◽  
Hiv 1

Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice

2019 ◽  
Vol 106 (4) ◽  
pp. 977-985 ◽  
Author(s):  
Anne Lippitsch ◽  
Nelli Baal ◽  
Yuri Chukovetskyi ◽  
Sarah Cunningham ◽  
Gabriela Michel ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Bacterial Pneumonia ◽  
Clinical Course ◽  
Plasmacytoid Dendritic Cell ◽  
Cell Depletion ◽  
T Cell Homeostasis ◽  
Cell Homeostasis

Blastic plasmacytoid dendritic cell neoplasm in a human T-cell lymphotropic virus type I (HTLV-1) carrier: a coincidental association?

2013 ◽  
Vol 23 (2) ◽  
pp. 250-251
Author(s):  
Youhei Uchida ◽  
Kazuhiro Kawai ◽  
Hidemichi Kubo ◽  
Koichiro Takeda ◽  
Mitsuyoshi Shimokawa ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Virus Type ◽  
Plasmacytoid Dendritic Cell ◽  
Type I ◽  
Human T Cell ◽  
Cell Neoplasm

SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms

Blood ◽  
2013 ◽  
Vol 121 (4) ◽  
pp. 643-647 ◽  
Author(s):  
Santiago Montes-Moreno ◽  
Rocio Ramos-Medina ◽  
Azahara Martínez-López ◽  
Carlos Barrionuevo Cornejo ◽  
Alejandro Parra Cubillos ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Transcription Factor ◽  
T Cell ◽  
Dendritic Cell ◽  
Cell Lymphoma ◽  
Plasmacytoid Dendritic Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Ets Transcription Factor ◽  
Hematolymphoid Neoplasms

Abstract SPIB is an Ets transcription factor that is expressed exclusively in mature B cells, T-cell progenitors, and plasmacytoid dendritic cells. In the present study, we developed a novel mAb against the SPIB protein and characterized its expression in major hematolymphoid neoplasms, including a series of 45 cases of blastic plasmacytoid dendritic cell (BPDC) neoplasms and their potential cutaneous mimics. We found that SPIB is expressed heterogeneously among B- and T-cell lymphoma types. Interestingly, SPIB is expressed in a large proportion of nongerminal center type DLBCLs. In cutaneous neoplasms, SPIB is overexpressed in all BPDC neoplasms, but none of its cutaneous mimics. SPIB remains overexpressed in all cases that lack 1 or 2 of the markers used for BPDC neoplasms (ie, CD4, CD56, TCL1, and CD123). We conclude that SPIB expression can be used as a tool for diagnosing BPDC neoplasms, but it needs to be tested in conjunction with the growing arsenal of markers for human plasmacytoid dendritic cells.

IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences

Blood ◽  
2003 ◽  
Vol 102 (13) ◽  
pp. 4487-4492 ◽  
Author(s):  
Omar Duramad ◽  
Karen L. Fearon ◽  
Jean H. Chan ◽  
Holger Kanzler ◽  
Jason D. Marshall ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Cpg Dinucleotides ◽  
Disease States ◽  
T Cell Priming ◽  
Anti Inflammatory Cytokine ◽  
Unmethylated Cytosine

AbstractImmunostimulatory sequences (ISS) are short oligonucleotides containing unmethylated cytosine-phosphate-guanine (CpG) dinucleotides that stimulate innate immune responses through Toll-like receptor-9 on B cells and plasmacytoid dendritic cell (PDC) precursors. The anti-inflammatory cytokine interleukin (IL)-10 is predicted to be a potent inhibitor of many of the activities described for ISS, and this may impact the use of ISS in disease states characterized by elevated IL-10. As the activities of ISS on PDCs are central to many clinical applications of ISS, we have studied the effects of IL-10 on PDC stimulation by 3 distinct classes of ISS. IL-10 inhibited cytokine production and survival of ISS-activated PDCs; however, IL-12 induction was much more sensitive to inhibition than interferon (IFN)-α induction. Within the PDC population are cells that respond to ISS by producing either IL-12 or IFN-α but not both cytokines. IL-12-producing PDCs require costimulation through CD40 and appear more mature than IFN-α-producing PDCs. The 3 distinct classes of ISS differed with respect to induction of PDC maturation and T-cell priming capacity. IL-10 regulated PDC activation but did not inhibit the subsequent T-cell-priming ability of PDCs already activated by ISS. (Blood. 2003;102:4487-4492)

scholarly journals Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity

AGE ◽  
2010 ◽  
Vol 33 (3) ◽  
pp. 363-376 ◽  
Author(s):  
Aishwarya Sridharan ◽  
Marc Esposo ◽  
Khushboo Kaushal ◽  
Jia Tay ◽  
Kathyrn Osann ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Cell Functions ◽  
Cell Immunity
Sign in / Sign up

Export Citation Format

Share Document