Prolonged Survival of Allogeneic Islets in Cynomolgus Monkeys After Short-Term Anti-CD154-Based Therapy: Nonimmunologic Graft Failure?

Quality of life was evaluated in 103 patients initially when each was placed on the waiting list for a cadaveric transplant. Patients who were not transplanted were reassessed six months after being placed on the waiting list. Patients who received a transplant were reassessed six months after the surgery. Cadaveric transplantation was performed in sixty-three patients by the time of follow-up. The mortality rate of 12.7 percent in transplanted patients after six months was more than twice that in patients who remained on the waiting list without a transplant, but this difference was not statistically significant. There was a graft failure rate of 23.6 percent among transplanted patients who survived six months. Graft failures were associated with some deterioration in subsequent physical activity ( F = 5.4, p < 0.03) but not in psychosocial functioning. Successful cadaveric transplants were associated with a marked and significant improvement in psychosocial well-being ( F = 10.5, p < 0.002) after six months even though physical activity did not increase. These findings suggest that 1) a successful cadaveric transplant is associated with an improved quality of life, 2) the graft failure rate of 23 percent with cadaveric transplantation is still appreciable but 3) graft failure is not necessarily associated in the short term with deterioration in psychosocial well-being.

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Levitronix as a Short-term Salvage Treatment for Primary Graft Failure After Heart Transplantation

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2005.11.458 ◽

2006 ◽

Vol 25 (5) ◽

pp. 495-498 ◽

Cited By ~ 42

Author(s):

G SANTISE ◽

M PETROU ◽

J PEPPER ◽

G DREYFUS ◽

A KHAGHANI ◽

...

Keyword(s):

Heart Transplantation ◽

Graft Failure ◽

Salvage Treatment ◽

Short Term ◽

Primary Graft Failure

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24 Prolonged survival of porcine hepatocytes in cynomolgus monkeys

Hepatology ◽

10.1016/s0270-9139(03)80067-8 ◽

2003 ◽

Vol 38 ◽

pp. 167-167

Author(s):

H NAGATA ◽

R NISHITAI ◽

C SHIROTA ◽

J ZHANG ◽

C KOCH ◽

...

Keyword(s):

Prolonged Survival ◽

Cynomolgus Monkeys ◽

Porcine Hepatocytes

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Prolonged Survival of Porcine Hepatocytes in Cynomolgus Monkeys

Gastroenterology ◽

10.1053/j.gastro.2006.10.013 ◽

2007 ◽

Vol 132 (1) ◽

pp. 321-329 ◽

Cited By ~ 63

Author(s):

Hideo Nagata ◽

Ryuta Nishitai ◽

Chiyoe Shirota ◽

Jia-Lin Zhang ◽

Cody A. Koch ◽

...

Keyword(s):

Prolonged Survival ◽

Cynomolgus Monkeys ◽

Porcine Hepatocytes

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Graft failure in cord blood transplantation successfully treated with short-term reduced-intensity conditioning regimen and second allogeneic transplantation

International Journal of Hematology ◽

10.1007/s12185-010-0714-6 ◽

2010 ◽

Vol 92 (5) ◽

pp. 744-750 ◽

Cited By ~ 17

Author(s):

Masahiko Sumi ◽

Ikuo Shimizu ◽

Keijiro Sato ◽

Toshimitsu Ueki ◽

Daigo Akahane ◽

...

Keyword(s):

Cord Blood ◽

Graft Failure ◽

Cord Blood Transplantation ◽

Conditioning Regimen ◽

Allogeneic Transplantation ◽

Reduced Intensity Conditioning ◽

Short Term ◽

Blood Transplantation ◽

Reduced Intensity Conditioning Regimen ◽

Reduced Intensity

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Short-term evaluation of a foraging device for non-human primates

Laboratory Animals ◽

10.1258/002367795780740096 ◽

1995 ◽

Vol 29 (4) ◽

pp. 364-369 ◽

Cited By ~ 7

Author(s):

S. N. Holmes ◽

J. M. Riley ◽

P. Juneau ◽

D. Pyne ◽

G. L. Hofing

Keyword(s):

Baseline Period ◽

Psychological Needs ◽

Term Effect ◽

Short Term ◽

Cynomolgus Monkeys ◽

Novel Food ◽

Short Term Effect ◽

Short Term Evaluation ◽

The Usa ◽

Term Evaluation

In the USA, any institution involved in using non-human primates for research has had, for regulatory reasons, to address the psychological needs of these animals. Enriching the environment through the use of foraging devices has been one method and a study was designed to evaluate the short-term effect of a new foraging device on singly-housed cynomolgus monkeys. The study was divided into 3 one-week periods of observation: baseline, device filled with normal ration, and device filled with a novel food. Four behaviours were recorded: foraging, self-directed, hopper feeding, and other behaviours. During the observation periods the device was accepted in preference to the standard hopper style feeder and self-directed behaviours were significantly reduced compared with the baseline period. Changing to a novel food re-kindled interest in the device and reduced the extinguishing effect: i.e. decrease in interest or use of the device. Based on this study, the feeder has been included with several other devices in a rotation programme.

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