LISE-LOTTE KIRKEVANG, DDS, PHD
Associate Professor
Department of Dental Pathology, Operative Dentistry & Endodontics
School of Dentistry, Faculty of Health Sciences
Aarhus University
Aarhus, Denmark

2008 ◽  
Vol 18 (1) ◽  
pp. 82-82
2008 ◽  
Vol 7 (3) ◽  
pp. 353-355
Author(s):  
Karen Fagan ◽  
Todd Bull ◽  
Ivan F. McMurtry ◽  
Omar A. Minai

This roundtable discussion, reviewing the proceedings from the Pulmonary Hypertension Association's Eighth International PH Conference and Scientific Sessions in Houston in 2008, was moderated by Karen Fagan, MD, Chief, Division of Pulmonary and Critical Care Medicine, University of South Alabama, Mobile, Alabama. It included Todd Bull, MD, Associate Professor of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Aurora, Colorado; Ivan F. McMurtry, PhD, Professor, Department of Pharmacology, University of South Alabama School of Medicine, Mobile, Alabama; and Omar A. Minai, MD, Staff Physician in the Department of Pulmonary, Allergy, and Critical Care Medicine and the Lung Transplant Center at the Cleveland Clinic, Cleveland, Ohio.


Radiology ◽  
1960 ◽  
Vol 74 (1) ◽  
pp. 124-124

2021 ◽  
Author(s):  
Charles E. Mordaunt ◽  
Julia S. Mouat ◽  
Rebecca J. Schmidt ◽  
Janine M. LaSalle

AbstractHealth outcomes are frequently shaped by difficult to dissect inter-relationships between biological, behavioral, social, and environmental factors. DNA methylation patterns reflect such multi-variate intersections, providing a rich source of novel biomarkers and insight into disease etiologies. Recent advances in whole-genome bisulfite sequencing (WGBS) enable investigation of DNA methylation over all genomic CpGs, but existing bioinformatic approaches lack accessible system-level tools. Here, we develop the R package Comethyl, for weighted gene correlation network analysis (WGCNA) of user-defined genomic regions that generates modules of comethylated regions, which are then tested for correlations with sample traits. First, regions are defined by CpG genomic location or regulatory annotation and filtered based on CpG count, sequencing depth, and variability. Next, correlation networks are used to find modules of interconnected nodes using methylation values within the selected regions. Each module containing multiple comethylated regions is reduced in complexity to a single eigennode value, which is then tested for correlations with experimental metadata. Comethyl has the ability to cover the noncoding regulatory regions of the genome with high relevance to interpretation of genome-wide association studies and integration with other types of epigenomic data. We demonstrate the utility of Comethyl on a dataset of male cord blood samples from newborns later diagnosed with autism spectrum disorder (ASD) versus typical development. Comethyl successfully identified an ASD-associated module containing gene regions with brain glial functions. Comethyl is expected to be useful in uncovering the multi-variate nature of health disparities for a variety of common disorders. Comethyl is available at github.com/cemordaunt/comethyl.Description of the AuthorsCharles E. Mordaunt, Ph.D. developed Comethyl while a postdoctoral fellow in the department of Medical Microbiology and Immunology at UC Davis. He is currently a Computational Biologist at GSK.Julia S. Mouat is a doctoral student in the Integrative Genetics and Genomics graduate group at UC Davis with interests in health disparities and intergenerational epigenetic risk factors for autism spectrum disorders.Rebecca J. Schmidt, Ph.D. is an Associate Professor of Public Health Sciences at UC Davis, with expertise in the use of epigenetics in epidemiology and neurodevelopmental disorders.Janine M. LaSalle, Ph.D. is a Professor of Medical Microbiology and Immunology, Co-Director of the Perinatal Origins of Disparities Center, and Deputy Director of the Environmental Health Sciences Center at UC Davis, with expertise in epigenomics and neurodevelopmental disorders.


2018 ◽  
Vol 9 (4) ◽  
pp. e102-110
Author(s):  
Jacqueline Green ◽  
Kari Rasmussen

Background: In each discipline, there are moments where students “get stuck” in their education and/or training and are often unable to move forward. These moments may be caused by threshold concepts as they represent a portal that students must cross in order to become successful in their chosen profession. This study investigated the threshold concepts from the instructors’ perspective that students must navigate as they transform from learners to dentists within a dental program.               Methods: Two focus groups with faculty members within the School of Dentistry, University of Alberta were completed in the fall of 2017. Focus groups explored the faculty’s perception of the students’ transition from learner to dentist, difficult moments in the program, and the students’ ability to navigate the program successfully.Results: A qualitative phenomenographic analysis of the faculty focus group transcripts identified four potential threshold concepts within the dental program: 1) dealing with the whole patient, 2) accountability, 3) that you may not know everything, and 4) problem solving and adapting during practice.Conclusion: This study demonstrates that there are concepts within a dental program that faculty believe students must navigate in order to transition from learner to dentist. These concepts may inform curriculum design as well as other disciplines in the health sciences.


2006 ◽  
Vol 5 (3) ◽  
pp. 34-39
Author(s):  
Karen A. Fagan ◽  
David B. Badesch ◽  
C. Gregory Elliott ◽  
Robert P. Frantz

This discussion was moderated by Karen A. Fagan, MD, Associate Professor of Medicine, University of Colorado Health Sciences Center, Denver, Colorado. Panel members included David B. Badesch, MD, Professor of Medicine, Divisions of Pulmonary Sciences & Critical Care Medicine, and Cardiology Clinical Director, Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, Colorado; C. Gregory Elliott, MD, Professor of Medicine, University of Utah School of Medicine, Pulmonary Division, LDS Hospital, Salt Lake City, Utah; and Robert P. Frantz, MD, Assistant Professor of Medicine, Mayo Clinic College of Medicine, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.


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