Prediction and non-invasive assessment of neonatal jaundice in the term healthy newborn infant

1996 ◽  
Vol 85 (4) ◽  
pp. 393-397 ◽  
Author(s):  
A Knudsen
Keyword(s):  
Newborn Infant ◽  
Neonatal Jaundice ◽  
Non Invasive ◽  
Healthy Newborn

Oxygen Consumption in Platelets of Newborn Infants before and after Stimulation by Thrombin.

1976 ◽  
Vol 35 (03) ◽  
pp. 712-716 ◽  
Author(s):  
D. Del Principe ◽  
G Mancuso ◽  
A Menichelli ◽  
G Maretto ◽  
G Sabetta
Keyword(s):  
Oxygen Consumption ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Newborn Infant ◽  
Umbilical Cord Blood ◽  
Newborn Infants ◽  
O2 Consumption ◽  
Adult Control ◽  
Healthy Newborn ◽  
Before And After

SummaryThe authors compared the oxygen consumption in platelets from the umbilical cord blood of 36 healthy newborn infants with that of 27 adult subjects, before and after thrombin addition (1.67 U/ml). Oxygen consumption at rest was 6 mμmol/109/min in adult control platelets and 5.26 in newborn infants. The burst in oxygen consumption after thrombin addition was 26.30 mμmol/109/min in adults and 24.90 in infants. Dinitrophenol did not inhibit the burst of O2 consumption in platelets in 8 out of 10 newborn infants, while the same concentration caused a decrease in 9 out of 10 adult subjects. Deoxyglucose inhibited the burst in O2 consumption in newborn infant and adult platelets by about 50%. KCN at the concentration of 10−4 M completely inhibited basal oxygen consumption but did not completely inhibit the burst after thrombin. At the concentration of 10−3 M, it inhibited both basal O2 consumption and the burst in infants and adult subjects.

scholarly journals Transcutaneous billirubinometry to estimate total serum bilirubin in neonatal jaundice

2017 ◽  
Vol 57 (1) ◽  
pp. 8 ◽  
Author(s):  
Andra Kurnianto ◽  
Herman Bermawi ◽  
Afifa Darmawanti ◽  
Erial Bahar
Keyword(s):  
Neonatal Jaundice ◽  
Serum Bilirubin ◽  
Subcutaneous Tissue ◽  
Correlation Coefficients ◽  
Total Serum Bilirubin ◽  
Blood Sampling ◽  
Total Serum ◽  
Transcutaneous Bilirubin ◽  
Non Invasive ◽  
Transcutaneous Bilirubinometry

Background The gold standard for diagnosis of neonatal jaundice is total serum bilirubin (TSB) measurement. This method, however, is invasive, painful, and costly in terms of workload, time, and money. Moreover, repeated blood sampling may lead to significant blood loss, which is of particular concern in preterm infants. To overcome these drawbacks, non-invasive methods of bilirubin measurement have been proposed. Transcutaneous bilirubinometry (TcB) determines the yellowness of the subcutaneous tissue of a newborn infant by measuring the difference between optical densities for light in the blue and green wavelength regions.Objective To evaluate the accuracy of transcutaneous bilirubinometry for estimating TSB levels in neonatal jaundice.Methods Subjects were infants aged < 28 days with jaundice who had never been treated with phototherapy or exchange transfusion. The study was done from February to July 2016 in Mohammad Hoesin Hospital. Subjects underwent transcutaneous bilirubin (TcB) and TSB assays, with a maximum interval of 15 minutes between tests.Results One hundred fifty patients were included in this study. The TcB values > 5 mg/dL were correlated to TSB > 5 mg/dL, with 100% sensitivity and 83.3% specificity. This cut-off point was obtained from a receiver-operator characteristic (ROC) curve with AUC 99.3% (95%CI 97.9 to 100%; P< 0.001).The correlation coefficients (r) for TSB and TcB measurements on the forehead were 0.897 (P<0.001).Conclusion Transcutaneous bilirubinometry can be used to accurately estimate TSB levels in neonatal jaundice, and may be useful in clinical practice as a non-invasive method to reduce blood sampling.

scholarly journals Dual role of cerebral blood flow in regional brain temperature control in the healthy newborn infant

2014 ◽  
Vol 37 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Sachiko Iwata ◽  
Ilias Tachtsidis ◽  
Sachio Takashima ◽  
Toyojiro Matsuishi ◽  
Nicola J. Robertson ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Newborn Infant ◽  
Temperature Control ◽  
Brain Temperature ◽  
Dual Role ◽  
Healthy Newborn ◽  
Regional Brain

Neonatal Mercury Vapor Exposure in an Infant Incubator

PEDIATRICS ◽  
1980 ◽  
Vol 66 (6) ◽  
pp. 988-990
Author(s):  
John F. McLaughlin ◽  
Robert W. Telzrow ◽  
Celia Mae Scott
Keyword(s):  
Newborn Infant ◽  
Body Burden ◽  
Mercury Vapor ◽  
Metallic Mercury ◽  
Heating Unit ◽  
Substantial Body ◽  
Healthy Newborn ◽  
Infant Incubator ◽  
Infant Incubators

A healthy newborn infant acquired a substantial body burden of mercury by inhaling mercury vapor originating from a broken mercury expansion switch in the heating unit of an infant incubator. Highly toxic mercury vapor is produced in quantity by heating otherwise harmless metallic mercury. Switches and thermometers that contain mercury should be removed from infant incubators.

The Colon in the Healthy Newborn Infant

Radiology ◽  
1942 ◽  
Vol 39 (3) ◽  
pp. 261-272 ◽  
Author(s):  
Samuel G. Henderson ◽  
W. W. Briant
Keyword(s):  
Newborn Infant ◽  
Healthy Newborn

Non-invasive bilirubinometry in neonatal jaundice

2002 ◽  
Vol 7 (2) ◽  
pp. 129-133 ◽  
Author(s):  
Giovanna Bertini ◽  
Firmino F. Rubaltelli
Keyword(s):  
Neonatal Jaundice ◽  
Non Invasive

scholarly journals Clinical utility of hand held, non invasive transcutaneous bilirubinometer in neonatal jaundice: a prospective observational study

2021 ◽  
Author(s):  
Bibhudatta Mishra ◽  
Bishwajit Mishra ◽  
Guruveera Jeyasingh Malini ◽  
Arjit Mohapatra ◽  
Prafulla Kumar Biswal ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Neonatal Jaundice ◽  
Prospective Observational Study ◽  
Screening Tool ◽  
Serum Bilirubin ◽  
Blood Sampling ◽  
Viable Option ◽  
Transcutaneous Bilirubin ◽  
Non Invasive ◽  
Transcutaneous Bilirubinometer

Background: Neonatal Jaundice is the most common morbidity in the first week of life, occurring in 60% of term and 80% of preterm newborn. However, visual inspection, being subjective, usually inaccurate and unreliable and will result in a number of unnecessary blood sampling. Taking all these in to considerations, transcutaneous bilirubinometer (TCB) may provide a solution which is an objective, noninvasive, fast and painless method of bilirubin estimation.Methods: Transcutaneous bilirubinometer levels were measured at forehead and sternum and blood samples for TSB were collected by venepuncture within 30 minutes and sent to biochemistry lab. After getting serum bilirubin reports, TCB and TSB values were compared by using Bhutani’s hour specific nomogram. Results: The correlation between serum bilirubin and transcutaneous bilirubin measured at forehead and sternum is very good at serum bilirubin <15 mg/dl, r value (Karl Pearson’s Correlation co-efficient) is 0.93 and 0.94 respectively.Conclusions: The findings of the present study indicate that the TCB is a reliable screening tool for hyperbilirubinemia in newborns >35 weeks of gestation, especially with bilirubin levels ≤15 mg/dl in 2-7 days of life. TCB can be a viable option for universal screening. Incorporating the use of TCB devices in clinical practice, can reduce the need for blood sampling for the management of neonatal jaundice.

Pulse Spectrophotometric Determination of Plasma Bilirubin in Newborns

2016 ◽  
Vol 5 (1) ◽  
pp. 21-30
Author(s):  
Erik Michel ◽  
Andreas Entenmann ◽  
Miriam Michel
Keyword(s):  
Spectrophotometric Determination ◽  
Neonatal Jaundice ◽  
Theoretical Concept ◽  
Computer Algorithms ◽  
Bilirubin Concentration ◽  
Signal Component ◽  
Non Invasive ◽  
Plasma Bilirubin ◽  
Fine Tune

In neonatal jaundice, plasma bilirubin has to be measured repeatedly in order to direct phototherapy. Invasive determination is standard. The authors delineate a concept for the non-invasive spectrophotometric determination of absolute plasma bilirubin concentration. By referencing the pulsatile spectrophotometric signal component of the metabolite of interest (MOI, here: bilirubin) to the pulsatile spectrophotometric signal component of a reference metabolite (MOR, here: water) of known plasma concentration, the absolute MOI concentration can be calculated. Based on Beer-Lambert's law and some reasonable assumptions, the authors developed a theoretical concept for the calculation of MOI concentration. They suggest light of 1200 nm wavelength to measure MOR, 795 nm and 570 nm to measure hemoglobin as correction signal, and 450 nm to measure the MOI. To enhance data quality one could assign several wavelengths to each metabolite. Since in tissue spectrophotometry Beer-Lambert's law does not reflect physiology accurately, it will be necessary to empirically fine-tune the computer algorithms.

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