Feσ RECEPTORS IN HUMAN CHOROID PLEXUS

Abstract Choroid plexus tumours (CPT) account for up to 20% of brain tumours in children under 2 years of age. Histologically CPTs are classified into three categories - Choroid Plexus Papilloma (CPP), Atypical Choroid Plexus Papilloma (ACPP) and Choroid Plexus Carcinoma (CPC). Recent literature demonstrates that CPP and ACPP are molecularly distinct from CPC. Initial management for CPT include surgery followed by adjuvant therapy in selected patients. Currently there are no disease-specific chemotherapeutic agents available, possibly because of their rarity and paucity of faithful pre-clinical experimental models. In this study we show that c-Myc overexpression in the choroid plexus epithelium induces T-cell inflammation-dependent choroid plexus papillomas in a mouse model. We demonstrate that c-MYC is expressed in a substantial proportion of human choroid plexus tumours and that this subgroup of tumours is characterised by an inflammatory transcriptome and significant inflammatory infiltrates. We observed that triple transgenic compound mutant mouse model with c-Myc overexpression in an immune-suppressed background led to a decreased incidence of CPP and reduced tumour bulk. A reduced tumour size was also observed when c-Myc overexpressing mice were treated with anti-CD3 antibodies. Our data raise the possibility that benign choroid plexus tumours expressing c-MYC could be amenable to medical therapy with anti-inflammatory drugs.

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Human choroid plexus is an uniquely involved area of the brain in amyloidosis: a histochemical, immunohistochemical and ultrastructural study

Brain Research ◽

10.1016/s0006-8993(97)00097-8 ◽

1997 ◽

Vol 755 (2) ◽

pp. 193-201 ◽

Cited By ~ 19

Author(s):

Atsushi Sasaki ◽

Misa Iijima ◽

Hideaki Yokoo ◽

Mikio Shoji ◽

Yoichi Nakazato

Keyword(s):

Choroid Plexus ◽

Ultrastructural Study ◽

Human Choroid Plexus ◽

The Brain

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Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development

The International Journal of Developmental Biology ◽

10.1387/ijdb.051996as ◽

2005 ◽

Vol 49 (7) ◽

pp. 859-865 ◽

Cited By ~ 19

Author(s):

Adam Swetloff ◽

Patrizia Ferretti

Keyword(s):

Choroid Plexus ◽

Intracellular Localization ◽

Choroid Plexus Epithelium ◽

Human Choroid Plexus

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Human choroid plexus: a light and electron microscopic study

Journal of Neurosurgery ◽

10.3171/jns.1970.33.5.0506 ◽

1970 ◽

Vol 33 (5) ◽

pp. 506-516 ◽

Cited By ~ 67

Author(s):

George J. Dohrmann ◽

Paul C. Bucy

Keyword(s):

Choroid Plexus ◽

Light And Electron Microscopy ◽

Morphological Characteristics ◽

Age Group ◽

Electron Microscopic ◽

Inclusion Type ◽

Content Type ◽

Intracytoplasmic Inclusions ◽

Human Choroid Plexus ◽

Choroid Plexuses

✓ Specimens of human choroid plexus, obtained during craniotomy, were examined by light and electron microscopy. Inclusions were observed within the cytoplasm of the choroidal epithelial cells, and could be classified into three types on the basis of morphological characteristics. Each inclusion type predominated in a particular age group. In choroid plexuses of older humans, filaments from 60 to 150 Å in diameter, with no apparent periodicity, were noted circumjacent to the intracytoplasmic inclusions.

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