Amelioration of Corticosteroid-Induced Type 2 Diabetes Mellitus by Rosiglitazone Is Possibly Mediated through Stimulation of Thyroid Function and Inhibition of Tissue Lipid Peroxidation in Mice

The aim of the study was to investigate the association between lipid peroxidation and antioxidant status in nonobese type 2 diabetes mellitus (T2DM) and further to correlate whether their significant association is putatively associated with the pathogenesis of T2DM. A number of 102 nonobese T2DM subjects and 95 nondiabetic subjects as healthy controls were enrolled in this cross-sectional study. Serum samples were collected in cryovials for malondialdehyde (MDA) and thiol assays. Total thiol or sulfhydryl (–SH) groups in peripheral blood mononuclear cells (PBMCs) and sera, as well as level of MDA, a marker for lipid peroxidation in serum, were measured spectrophotometrically. Serum MDA level was found significantly higher whereas serum and PBMC total thiol levels were diminished significantly among nonobese T2DM subjects compared to HC subjects. Moreover, serum MDA level is found to have a significant inverse correlation with serum total thiol and PBMC thiol levels among DM subjects, but no significant correlation was observed in HC individuals. A significant inverse correlation between serum MDA and serum total thiol levels among nonobese T2DM subjects suggests a close association of increased oxidative stress with decreased antioxidant status in nonobese T2DM.

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Paraoxonase activity and lipid peroxidation in female patients with type 2 diabetes mellitus and without coronary heart disease

Problems of Endocrinology ◽

10.14341/probl11394 ◽

2003 ◽

Vol 49 (1) ◽

pp. 17-20

Author(s):

M. Yu. Gorshunskaya.

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Lipid Peroxidation ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

High Density ◽

High Density Lipoproteins ◽

Paraoxonase Activity

The rate of lipid peroxidation and the parameters of antioxida- tive defense, including the activity of paraoxonase that is essential for the prevention of low-density lipoprotein oxidation, was studied in 229female patients with type 2 diabetes mellitus with and without coronary heart disease (CHD) under varying glycemic control. Carbohydrate and lipid metabolisms were explored by unified biochemical studies, blood insulin levels were measured by radioimmunological assay. The activity of paraoxonase associated with high-density lipoproteins of ester hydrolase was spectrophotometrically determined by using paraoxan as a substrate. Along with dyslipoproteinemia and insulin resistance, there was a drastically reduced paraoxonase activity that was associated with the high-density lipoproteins of the antioxidant enzyme and more pronounced in diabetics with CHD. A highly significant inverse correlation of the activity of the enzyme with the rate of lipid peroxidation and a less close relationship to basal glycemia have been verified, which substantiates the polygenic nature of decreased paraoxonase activity in diabetes mellitus.

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Study of lipid peroxidation, nitric oxide end product, and trace element status in type 2 diabetes mellitus with and without complications

International Journal of Applied and Basic Medical Research ◽

10.4103/2229-516x.205813 ◽

2017 ◽

Vol 7 (2) ◽

pp. 88 ◽

Cited By ~ 15

Author(s):

Sanjukta Mishra ◽

BanaBihari Mishra

Keyword(s):

Nitric Oxide ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Lipid Peroxidation ◽

Type 2 Diabetes Mellitus ◽

Trace Element ◽

Trace Element Status

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A new principle of the treatment of type 2 diabetes mellitus by stimulation of glucosuria

Problems of Endocrinology ◽

10.14341/probl201258454-57 ◽

2012 ◽

Vol 58 (4) ◽

pp. 54-57 ◽

Cited By ~ 1

Author(s):

V Ia Shvarts

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Urinary Tract ◽

Adverse Reactions ◽

Experimental Studies ◽

Pharmaceutical Products ◽

Subsequent Decrease ◽

Stimulation Of

The results of clinical and experimental studies of a new group of medications are presented, with special emphasis laid on the inhibitors of sodium-glucose co-transporter SGLT2 employed for the treatment of type 2 diabetes mellitus. The mechanism of action of these inhibitors consists of the stimulation of glucosuria and the subsequent decrease of hyperglycemia. The new group of pharmaceutical products being considered is characterized by high therapeutic efficacy, safety, and the narrow spectrum of side effects. The most important adverse reactions are infectious lesions in the urinary tract and genital organs.

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