Canine dilated cardiomyopathy: a retrospective study of signalment, presentation and clinical findings in 369 cases

Abstract Background Pneumocystis pneumonia (PCP) severely menaces modern chemotherapy and immunosuppression. Detailed description of the epidemiology of Pneumocystis jirovecii today is needed to identify candidates for PCP-prophylaxis. Methods We performed a 12-year retrospective study of patients with P. jirovecii detected by polymerase chain reaction in Central Norway. In total, 297 patients were included. Comprehensive biological, clinical and epidemiological data were abstracted from patients’ medical records. Regional incidence rates and testing trends were also assessed. Results From 2007 to 2017 we found a 3.3-fold increase in testing for P. jirovecii accompanied by a 1.8-fold increase in positive results. Simultaneously, regional incidence rates doubled from 5.0 cases per 100,000 person years to 10.8. A majority of the study population had predisposing conditions other than human immunodeficiency virus (HIV). Hematological (36.0%) and solid cancers (25.3%) dominated. Preceding corticosteroids were a common denominator for 72.1%. Most patients (74.4%) presented with at least two cardinal symptoms; cough, dyspnea or fever. Main clinical findings were hypoxia, cytopenias and radiological features consistent with PCP. A total of 88 (29.6%) patients required intensive care and 121 (40.7%) suffered at least one complication. In-hospital mortality was 21.5%. Three patients (1.0%) had received prophylaxis. Conclusions P. jirovecii is re-emerging; likely due to increasing immunosuppressants use. This opportunistic pathogen threatens the life of heterogenous non-HIV immunosuppressed populations currently at growth. Corticosteroids seem to be a major risk factor. A strategy to increase prophylaxis is called for.

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Canine dilated cardiomyopathy 1. Breed manifestations and diagnosis

In Practice ◽

10.1136/inpract.22.9.520 ◽

2000 ◽

Vol 22 (9) ◽

pp. 520-530 ◽

Cited By ~ 4

Author(s):

Joanna Dukes McEwan

Keyword(s):

Dilated Cardiomyopathy ◽

Canine Dilated Cardiomyopathy

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Taurine-Deficient Dilated Cardiomyopathy in a Family of Golden Retrievers

Journal of the American Animal Hospital Association ◽

10.5326/0410284 ◽

2005 ◽

Vol 41 (5) ◽

pp. 284-291 ◽

Cited By ~ 26

Author(s):

Marie C. Bélanger ◽

Mathieu Ouellet ◽

Guillaume Queney ◽

Maxim Moreau

Keyword(s):

Dilated Cardiomyopathy ◽

Systolic Function ◽

Response To Therapy ◽

Heart Murmur ◽

Taurine Supplementation ◽

Canine Dilated Cardiomyopathy ◽

Fractional Shortening

A reversible taurine-deficient dilated cardiomyopathy occurred in five related golden retrievers. An apical systolic heart murmur was the most common physical abnormality. According to fractional shortening and end-systolic diameter on echocardiography, significant improvements (P<0.005) were recorded within 3 to 6 months of starting taurine supplementation. The dogs regained substantial systolic function, and four were weaned off all cardiac medications except taurine. This response to therapy was unusual, because canine dilated cardiomyopathy is generally progressive and fatal.

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Respiratory Candida in Patients with Bronchitis, Mucus Plugging, and Atelectasis

The Open Respiratory Medicine Journal ◽

10.2174/1874306402014010087 ◽

2020 ◽

Vol 14 (1) ◽

pp. 87-92

Author(s):

Douglas C. Johnson ◽

Suresh K. Chirumamilla ◽

Armando P. Paez

Keyword(s):

Retrospective Study ◽

Respiratory Failure ◽

Clinical Findings ◽

Clinical Parameters ◽

Poor Outcome ◽

Sputum Production ◽

Uncertain Significance ◽

Clinically Significant

Background: The significance of Candida in pulmonary secretions is unclear, and usually is regarded as colonization, not contributing to symptoms or disease. Yet, in our experience, Candida seemed associated with chronic sputum, mucus plugging, atelectasis, and poor outcome. Objective: The aim of this study is to describe the clinical findings of patients with Candida in pulmonary (sputum or bronchoscopy) secretions and the significance of Candida. Methods: Retrospective study of inpatients and outpatients referred for pulmonary consultation with Candida in pulmonary secretions. Clinical parameters and estimates of whether Candida was likely clinically significant, were determined. Results: 82 inpatients and 11 outpatients were identified, of which 61 (66%) had atelectasis and 68 (73%) bronchoscopies. Of patients having bronchoscopies, 56 (82%) had mucus, and 43 (63%) mucus plugging. Of the inpatients death (or probable death) occurred in 43 (63%), 42 (98%) of which were from definite or probable respiratory failure, with 13 (31%) likely related to mucus plugging, 16 (38%) possibly from mucus plugging, 6 (14%) unknown, and 7 (17%) not due to mucus plugging. Candida was felt likely clinically significant in 57 patients (61%), uncertain significance in 23 (25%), and not significant in 13 (14%). All outpatients had exacerbations, including 7 (64%) within a year. Conclusion: Patients requiring pulmonary consultation with Candida in pulmonary secretions often have chronic sputum production, exacerbations, mucus plugging, atelectasis, and death from respiratory failure. Candida was likely clinically significant in most patients. Recommendations to consider Candida in pulmonary secretions as colonization should be reconsidered.

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Epidemiological Features of Neonates With COVID-19 Infection in Iran

10.21203/rs.3.rs-1141407/v1 ◽

2021 ◽

Author(s):

Parisa Mohagheghi ◽

Fereshteh Moshfegh ◽

Nazanin Zafaranloo ◽

Narjes Khalili ◽

Mohammad Heidarzadeh ◽

...

Keyword(s):

Retrospective Study ◽

Respiratory Distress ◽

Gestational Age ◽

National Registry ◽

Clinical Findings ◽

Study Data ◽

Cross Sectional ◽

Epidemiological Features ◽

Common Sign ◽

Pcr Test

Abstract Objective: Although, the COVID-19 Pandemic has drawn the attention of physicians and researchers from all corners of the globe since it has been out broken in different countries, we have also started to invest more about the epidemiological features of neonates that had been affected by COVID-19 in Iran till now.Method: This is a cross-sectional retrospective study including all neonates from a National Registry supported by Iranian Maternal and Neonatal Network (IMaN). Since February 2020 till February 2021, data of neonates under 28 days who were diagnosed with suspected or confirmed COVID-19 has been registered in this network were collected. General data including epidemiological, clinical outcomes and infection-related information were collected. Results: In our retrospective study, data of 4015 neonates admitted to hospital all over the country and reported in IMAN is included. Totally 3725 PCR tests were performed (92.8% of admitted neonates) and from these neonates 825 (20.5%) showed positive PCR test. There were no differences between gender, weight and gestational age in neonates with positive and negative PCR test. Neonatal clinical findings were dependent to the type of admission. Respiratory distress was the most common sign in neonates, who were admitted immediately after birth (63.9%), and who were transferred from another hospital (17%); however in those who were admitted after one to several days after discharge (19.1%), the most common sign were sepsis like syndrome (31.8%) and fever (27.4%). Almost 50% of admitted neonate`s mothers had positive PCR test (25% during pregnancy and 24.3% after delivery). The most important factor of neonatal death was need for respiratory support (aOR=18.17, 95% CI; 9.24– 35.69). Gestational age of <32 weeks (aOR=2.35, 95% CI; 1.35-4.10) and birth weight of <1500 grams (aOR= 3.47, 95% CI; 1.96-6.17) were the other two factors that correlated to death. Conclusion: This is the largest study of neonatal COVID-19 diseases in Iran published to date. The most common signs of COVID-19 diseases found in neonates are respiratory distress and sepsis-like syndrome.

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Canine dilated cardiomyopathy

BSAVA Manual of Canine and Feline Cardiorespiratory Medicine ◽

10.22233/9781905319534.23 ◽

2010 ◽

pp. 200-212 ◽

Cited By ~ 4

Author(s):

Joanna Dukes-McEwan

Keyword(s):

Dilated Cardiomyopathy ◽

Canine Dilated Cardiomyopathy

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Dorsiflexion Osteotomy in Freiberg's Disease

Foot & Ankle ◽

10.1177/107110078900900504 ◽

1989 ◽

Vol 9 (5) ◽

pp. 226-231 ◽

Cited By ~ 41

Author(s):

Patrick Kinnard ◽

Richard Lirette

Keyword(s):

Patient Satisfaction ◽

Retrospective Study ◽

Average Duration ◽

Clinical Findings ◽

Minimal Loss ◽

Freiberg’S Disease

A retrospective study of the postsurgical results of 10 patients who had dorsiflexion osteotomy was undertaken. Patient satisfaction, clinical findings, and roentgenographic measurements were all carefully evaluated after an average duration of follow-up of 36.5 months. The procedure gave excellent results for all patients, with minimal loss of metatarsophalangeal motion and an average radiological metatarsal shortening of 2.3 mm and no postoperative metatarsalgia. The authors believe that the dorsiflexion osteotomy is a reasonable treatment for symptomatic Freiberg's disease. The procedure is reliable and not destructive, should further treatment be necessary.

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