Bruxismo Infantil: Uma Revisão de Literatura / Children's Bruxism: A Literature Review

Resumo: O objetivo do presente estudo foi discutir aspectos do bruxismo infantil através de uma revisão de literatura, abordando os fatores etiológicos bem como sinais, sintomas e características clínicas desta condição. É de grande importância o domínio dos sinais e sintomas para um diagnóstico mais preciso pelos profissionais da odontopediatria. O tratamento é multidisciplinar para esta condição parafuncional. Os resultados demonstraram ser o bruxismo um hábito não funcional da função mastigatória, que se caracteriza , pelo ato de apertar ou ranger os dentes, ocorrendo tanto durante o dia como no momento do sono. A etiologia é multifatorial e a literatura apresenta diversos, tais como fatores associados: dentário, fisiológico, psicológico e neurológico. O sinal mais comum é um certo desgaste nas faces incisais, principalmente dos dentes anteriores e, oclusais nos dentes posteriores. Também tende a ocasionar hipersensibilidade dentária, fratura de cúspides e restaurações e hipertonicidade dos músculos mastigatórios. Concluiu-se que conhecer os fatores etiológicos e as características clínicas do bruxismo na infância é importante para um diagnóstico o mais rápido possível, permitindo um tratamento precoce que favoreça o bem-estar da criança. Palavras-chave: bruxismo; crianças; odontopediatria. Abstract: The aim of this study was to discuss aspects of childhood bruxism through a literature review, addressing the etiological factors as well as signs, symptoms and clinical characteristics of this condition. It is very important to master the signs and symptoms for a more accurate diagnosis by pediatric dentistry professionals. Treatment is multidisciplinary for this parafunctional condition. The results showed that bruxism is a non-functional habit of the masticatory function, which is characterized by the act of squeezing or grinding the teeth, occurring both during the day and during sleep. The etiology is multifactorial and the literature presents several, such as associated factors: dental, physiological, psychological and neurological. The most common sign is some wear on the incisal surfaces, especially on the anterior teeth, and occlusal on the posterior teeth. It also tends to cause tooth hypersensitivity, fracture of the cusps and restorations, and hypertonicity of masticatory muscles. It was concluded that knowing the etiological factors and clinical characteristics of bruxism in childhood is important for a diagnosis as quickly as possible, allowing an early treatment that favors the child's well-being.Keywords: bruxism; kids; pediatric dentistry.

Epidemiological Features of Neonates With COVID-19 Infection in Iran

Objective: Although, the COVID-19 Pandemic has drawn the attention of physicians and researchers from all corners of the globe since it has been out broken in different countries, we have also started to invest more about the epidemiological features of neonates that had been affected by COVID-19 in Iran till now.Method: This is a cross-sectional retrospective study including all neonates from a National Registry supported by Iranian Maternal and Neonatal Network (IMaN). Since February 2020 till February 2021, data of neonates under 28 days who were diagnosed with suspected or confirmed COVID-19 has been registered in this network were collected. General data including epidemiological, clinical outcomes and infection-related information were collected. Results: In our retrospective study, data of 4015 neonates admitted to hospital all over the country and reported in IMAN is included. Totally 3725 PCR tests were performed (92.8% of admitted neonates) and from these neonates 825 (20.5%) showed positive PCR test. There were no differences between gender, weight and gestational age in neonates with positive and negative PCR test. Neonatal clinical findings were dependent to the type of admission. Respiratory distress was the most common sign in neonates, who were admitted immediately after birth (63.9%), and who were transferred from another hospital (17%); however in those who were admitted after one to several days after discharge (19.1%), the most common sign were sepsis like syndrome (31.8%) and fever (27.4%). Almost 50% of admitted neonate`s mothers had positive PCR test (25% during pregnancy and 24.3% after delivery). The most important factor of neonatal death was need for respiratory support (aOR=18.17, 95% CI; 9.24– 35.69). Gestational age of <32 weeks (aOR=2.35, 95% CI; 1.35-4.10) and birth weight of <1500 grams (aOR= 3.47, 95% CI; 1.96-6.17) were the other two factors that correlated to death. Conclusion: This is the largest study of neonatal COVID-19 diseases in Iran published to date. The most common signs of COVID-19 diseases found in neonates are respiratory distress and sepsis-like syndrome.

Laurence-Moon-Bardet-Biedl syndrome

Lawrence-Moon-Bardet-Biedl syndrome is a rare autosomal recessive genetic disorder, which may result in a number of multiorgan abnormalities, including impaired brain function, eye diseases, kidney and limbs’ dysfunction. The main symptoms of this syndrome include retinal degeneration, polydactyly, obesity, hypogonadism, congenital kidney abnormalities and mental retardation. However, Lawrence-­Moon­-Barde­-Biedl syndrome may also present with other secondary abnormalities, including ataxia, diabetes insipidus, and dental abnormalities. Clinical changes of the eyes include retinitis pigmentosa, low visual acuity, and vision loss, often due to photoreceptor disorders in the retinal tissue with macular degeneration, leading to night blindness and then, in most cases, can cause complete blindness. In patients with an archetypal manifestation of Lawrence­-Moon­-Barde-­Biedl syndrome, abdominal obesity is common, even if the birth weight is usually normal. In addition, this group of patients has type 2 diabetes mellitus. A distinctive feature of this syndrome is postaxial polydactyly. Hypogonadism, which is a common sign of the disease, as usual can be diagnosed at early age in men in a form of micropenis and testicular hypoplasia).The paper presents clinicalcase of Lawrence­-Moon­-Barde-­Bidle syndrome in a thirteen-year-old boy who referred to endocrinologist with complaints of excessivegain of body weight, memoryloss, visual impairment, difficulties in school, delayedsexual development. Ad ditional investigations enabled to establish the diagnosis of Laurence­-Moon­-Bardet­-Biedl syndrome.

Hydrocephalus Surgery in Touba City (Senegal): 0% infection Preliminary study about 20 cases

Introduction: Infection is the most common complication encountered after ventriculoperitoneal shunt. The AIMS of this study is to evaluate the effectiveness of antibiotic therapy with protocol in the prevention of post-operative infections after ventriculoperitoneal shunt in our city. Patients and methods: We retrospectively study 20 hydrocephalus cases in one year. They were operated through the classic VP Shunt insertion technique and with the protocol adopted for shunt implantation. They received antibiotic therapy for ten days. Results: In one year we operated 95 patients,20 (21%) cases were hydrocephalus. There were 7 males et 13 females (ratio:0,53) . The age of patients ranged from 15 days to 12 years and the average age was 13,5 months. The average consultation time was 5,6 weeks. Clinically the most common sign were anterior fontanelle tense (100%) , macrocrania (60%) ,vomiting (80%) and sunset eye sign (80%) . Brain CT-scan was performed in all patient,66% of patients had Transfontanelle Ultrasonography and anyone hadn’t performed MRI. All cases underwent surgical treatment. only ventriculoperitoneal shunt was performed and the standard technique protocol to minimize infection was done during surgery. All of them received ceftriaxone 100mg/kg/day for five days then oral relay by thiamphenicol 50mg/Kg/day for five days. The follow up was good no infection was found (0%). Conclusion: Establishing an aseptic protocol for the shunt is essential to reduce the rate of postoperative infections. This result becomes better when we make a combination of antibiotic therapy and protocol. We can achieve infection rates to zero or less than 1% in case of association

Epigenetic Mechanisms of Cardioprotection: Focus is on Activation of Sirtuins

Oxidative stress is a common sign of aging and cardiovascular disease (CVD), including atherosclerosis, heart failure, hypertension, diabetes mellitus and other diseases of the vascular system. In this regard, in recent years, researchers have shown increased interest in sirtuins (SIRTs) — stress adapters and epigenetic enzymes involved in cellular mechanisms for controlling age-related pathologies, cancer and CVD. Among sirtuins, of which there are seven in mammals (SIRT1-SIRT7), SIRT1 and SIRT6 possess the most cardioprotective, anti-inflammatory, atheroprotective and anti-aging properties. In this review, we present a comprehensive analysis of the latest developments in the field of cellular and molecular signaling pathways controlled by two post-translational modifiers — SIRT1 and SIRT6, which have proven their worth as tools to reduce inflammation and oxidative stress at the level of the cardiovascular system. A deeper understanding of the epigenetic mechanisms through which SIRT1 and SIRT6 exert their cardioprotective effect will have widespread implications and will accelerate the development of selective and effective pharmacological agents for modulating sirtuins for the prevention and treatment of CVD.

Demixing in the plasma created in capillary discharges with polymeric wall

The results of spectral diagnostics of erosion plasma obtained in a pulsed discharge in a capillary with an evaporating wall made of hydrogen-carbon and fluorine-carbon polymers - polymethylmethacrylate and polytetrafluoroethylene - are presented. It was found that in both cases the distribution of chemical elements along the discharge radius is highly inhomogeneous, and their concentration ratio differs significantly from that in the capillary wall. The mass of particles is a common sign characterizing the demixing degree of chemical elements and direction of diffusion flows in fluorine-carbon and hydrogen-carbon plasmas. In both cases, lightweight particles are concentrated in the central high-temperature region, while heavy ones run away onto the low-temperature peripheral region of the discharge. Estimates show that the thermal diffusion mechanism is quite capable for providing the observed demixing degree of chemical elements. Favorable conditions for thermal diffusion processes are formed in the layer adjacent to the capillary wall, where the intense dissociation of radicals occurs, and the temperature gradient reaches up to ΔT∼10 eV/mm.

A Clinical Study on Laparoscopic Cholecystectomy in a Tertiary Care Teaching Hospital

Background: Laparoscopic cholecystectomy is gaining popularity for the surgical treatment of gallbladder diseases. The technique has advantages of safe surgery, minimal complications, lower duration of hospital stay, and early return to normal activities. We in the current study tried to evaluate the outcomes of laparoscopic cholecystectomies done in our tertiary care teaching hospital. Methods: Based on the inclusion and exclusion criteria n=40 cases were identified and treated with laparoscopic cholecystectomy. A complete history which included the pasthistory, family history, socioeconomic status, nature of symptoms, diet history was obtained. All the patients underwent a complete clinical examination. The investigations carried out were complete blood picture, bleeding time, clotting time, ECG, LFT, KFT, FBS, blood groups, chest x-ray, and Ultrasound scan of the abdomen. All cases were operated as per the standard procedures. Results: The most common sign recorded in the cases was pain in right hypochondrium. Out of n=40 cases, 95% were present with pain 5% was without pain. Clinical jaundice was found in 10% of cases and tenderness was found on examination in 95% of cases. USG showed the presence of multiple stones was in 76% of cases, thickening of the gall bladder was in 80% cases and presence of mass was detected in 8% of cases. The follow-up period was 3 months in which no complications were reported. Conclusion: The study found that most of the cases of cholelithiasis now occurring across the spectrum of different ages. The diagnosis has now become easy with the presence of ultrasonography which has sensitivity and specificity. The motto of safe surgery, low morbidity, and early back to work is best done with laparoscopic cholecystectomy.

Clinical Decision Support System for Detection of Dengue

Dengue fever is caused due to the mosquito (Aedel aegypti) bite. The symptoms of this fever are similar to other fevers such as Malaria, Chikungunya and Zika. A common sign of Dengue fever is the sharp fall of blood platelet count, amongst other a host of other confusing symptoms, which makes Dengue difficult to diagnose, especially by an inexperienced physician. The purpose of this study is to outline a decision support system (DSS) which would come to the aid of detection of Dengue fever by carrying out an analysis of AHP and fuzzy AHP (FAHP) methodology. The data of confirmed Dengue as diagnosed by a physician is picked up, examined independently using AHP and FAHP approach, the results obtained are then compared with the diagnosis report of an expert doctor. The outcome is encouraging and indicates that expert systems can be leveraged for the diagnosis of Dengue and can be a useful tool for non-expert physicians

Epidemiological Aspects and Seasonal Variation of Meningitis in Egyptian Patients: a Single-Center Study at Abbassia Fever Hospital from 2006 to May 2017

Background As a result of dangerous complications caused by Meningitis, early recognition, and rapid starting of therapy is very important. Objectives To have an epidemiological profile of patients admitted with meningitis to Abbassia Fever Hospital from year 2006 to May 2017. Patients and methods Meningitis Have a seasonal variations. And this study was done to achieve an epidemiological profile of patients admitted with meningitis to Abbassia Fever Hospital from January 2006 to May 2017. Our study was conducted as retrospective descriptive study at Abbassia Fever Hospital from January 2006 to May 2017. on all of patients admitted to Abbassia Fever Hospital by using data Extraction Sheet. Results Meningitis was more common in Adult age group 60.8%. Meningitis was more common in males 64.4%. More common in Cairo 60.1%. in Cairo it is more common in Nasr city 8.8%. Seasonal variation of meningitis cases was demonstrated in this study with the highest incidence in winter and Spring. The most common symptom of meningitic patients were fever 89.2% followed by convulsions 12.1%, vomiting 10.% and then Headache 7.8% The most common sign in meningitic patients were neck rigidity in 66%, Kernig’s sign in 60%, and Brudizinski’s sign in 40% of patients. Patient of meningitis had convulsions 18.6% and DCL 30.4%, the convulsion and DCL are related to ICU admission. 30.1% of patients of meningitis admitted to ICU. Conclusion Meningitis is more common in males, more common in Cairo.in Cairo it is more common in Nasr city. Meningitis has a seasonal variation commonly, in winter and Spring.

Comparison between Neutrophil Lymphocyte Ratio and Derived Neutrophil Lymphocyte Ratio as the Risk Factor of COVID-19

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Respiratory disorders were the most common sign and symptom of COVID-19. Inflammation on SARS-CoV-2 infection is presumed to play a role in the pathogenesis of COVID-19. The Neutrophil Lymphocyte Ratio (NLR) is one of many biomarkers that has been widely used to assess the risk factors of COVID-19. The derived Neutrophil Lymphocyte Ratio (d-NLR) is a simple, inexpensive, and widely available inflammation biomarker. However, its usage for COVID-19 remains to be further studied. This study aimed to determine the NLR and d-NLR ratio as a risk factor of COVID-19. This study was a retrospective study with a study population of 84 subjects, consisting of 33 patients with positive COVID-19 and 51 patients with negative COVID-19. The result showed that the odds ratio of NLR to COVID-19 was 2.665 with the p-value of 0.047 and confidence interval of 95% 0.998-7.038 at cut-off ≥ 3.1. The odd ratio of d-NLR to COVID-19 was 2.808 with the p-value of 0.026 and confidence interval of 95% 1.129-7.038 at cut-off ≥ 2.0. In conclusion, despite a higher odd ratio of d-NLR compared to NLR, both NLR and d-NLR can be used as a biomarker for the risk factor of COVID-19.