p22/PACAP Response Gene 1 (PRG1): A Putative Target Gene for the Tumor Suppressor p53

1998 ◽  
Vol 865 (1 VIP, PACAP, A) ◽  
pp. 27-36 ◽  
Author(s):  
HEINER SCHAFER ◽  
ANNA TRAUZOLD ◽  
THORSTEN SEBENS ◽  
WOLFGANG DEPPERT ◽  
ULRICH R. FOLSCH ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Target Gene ◽  
Tumor Suppressor P53 ◽  
Putative Target Gene ◽  
Response Gene ◽  
Putative Target

Identification, expression, and putative target gene analysis of nuclear factor-Y (NF-Y) transcription factors in tea plant (Camellia sinensis)

Planta ◽  
2019 ◽  
Vol 250 (5) ◽  
pp. 1671-1686 ◽  
Author(s):  
Pengjie Wang ◽  
Yucheng Zheng ◽  
Yongchun Guo ◽  
Xuejin Chen ◽  
Yun Sun ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Camellia Sinensis ◽  
Target Gene ◽  
Tea Plant ◽  
Gene Analysis ◽  
Nuclear Factor ◽  
Putative Target Gene ◽  
Nuclear Factor Y ◽  
Putative Target

Identification ofPAK4as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma

2009 ◽  
Vol 100 (10) ◽  
pp. 1908-1916 ◽  
Author(s):  
Asma Begum ◽  
Issei Imoto ◽  
Ken-ichi Kozaki ◽  
Hitoshi Tsuda ◽  
Emina Suzuki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Target Gene ◽  
Putative Target Gene ◽  
Putative Target

scholarly journals Thrombospondin-1 Is a Putative Target Gene of Runx2 and Runx3

2013 ◽  
Vol 14 (7) ◽  
pp. 14321-14332 ◽  
Author(s):  
Xiuming Shi ◽  
Vishwa Deepak ◽  
Linghui Wang ◽  
Xueqing Ba ◽  
Toshihisa Komori ◽  
...  
Keyword(s):  
Target Gene ◽  
Putative Target Gene ◽  
Putative Target ◽  
Thrombospondin 1

scholarly journals Mutations Modulating Raf Signaling in Drosophila Eye Development

Genetics ◽  
1996 ◽  
Vol 142 (1) ◽  
pp. 163-171
Author(s):  
Barry J Dickson ◽  
Alexandra van der Straten ◽  
María Domínguez ◽  
Ernst Hafen
Keyword(s):  
Target Gene ◽  
Eye Development ◽  
Mitogen Activated Protein Kinase ◽  
Putative Target Gene ◽  
Raf Kinase ◽  
Putative Target ◽  
Drosophila Eye ◽  
Mitogen Activated Protein ◽  
Inductive Signal ◽  
Kinase Homologue

The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue; another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.

scholarly journals Identification ofstarmaker-likein medaka as a putative target gene of Pax2 in the otic vesicle

2009 ◽  
Vol 238 (11) ◽  
pp. 2860-2866 ◽  
Author(s):  
Baubak Bajoghli ◽  
Mirana Ramialison ◽  
Narges Aghaallaei ◽  
Thomas Czerny ◽  
Joachim Wittbrodt
Keyword(s):  
Target Gene ◽  
Otic Vesicle ◽  
Putative Target Gene ◽  
Putative Target

scholarly journals Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress

2021 ◽  
Author(s):  
Luis Coronel ◽  
Konstantin Riege ◽  
Katjana Schwab ◽  
Silke Förste ◽  
David Häckes ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Target Gene ◽  
Target Genes ◽  
Cell Types ◽  
Factor X ◽  
Tumor Suppressor P53 ◽  
Established Tumor ◽  
Distinct Cell ◽  
Signaling Axis ◽  
Cancer Types

AbstractDespite its prominence, the mechanisms through which the tumor suppressor p53 regulates most genes remain unclear. Recently, the regulatory factor X 7 (RFX7) emerged as a suppressor of lymphoid neoplasms, but its regulation and target genes mediating tumor suppression remain unknown. Here, we identify a novel p53-RFX7 signaling axis. Integrative analysis of the RFX7 DNA binding landscape and the RFX7-regulated transcriptome in three distinct cell systems reveals that RFX7 directly controls multiple established tumor suppressors, including PDCD4, PIK3IP1, MXD4, and PNRC1, across cell types and is the missing link for their activation in response to p53 and stress. RFX7 target gene expression correlates with cell differentiation and better prognosis in numerous cancer types. Interestingly, we find that RFX7 sensitizes cells to Doxorubicin by promoting apoptosis. Together, our work establishes RFX7’s role as a ubiquitous regulator of cell growth and fate determination and a key node in the p53 transcriptional program.

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