Vitamin K, Vitamin E And The Coumarin Drugs

2009 ◽  
Vol 40 (6) ◽  
pp. 180-182 ◽  
Keyword(s):  
2002 ◽  
Vol 87 (3) ◽  
pp. 219-226 ◽  
Author(s):  
H. H. W. Thijssen ◽  
M.-J. Drittij ◽  
C. Vermeer ◽  
E. Schoffelen

The effect of maternal phylloquinone supplementation on vitamin K in breast milk was studied to establish: (1) if phylloquinone is the source of menaquinone-4 in breast milk; (2) the dose–effect relationship between intake and obtainable levels. Four groups of lactating mothers with a full-term healthy infant participated and took oral phylloquinone supplements of 0·0 (n8), 0·8 (n8), 2·0 (n8), and 4·0 (n7) mg/d for 12 d, starting at day 4 post-partum. Milk samples were collected on days 4, 8, 16, and 19. Blood samples were collected on days 4 and 16. Vitamin K and vitamin E concentrations, the latter for reason of comparison, were assayed. Phylloquinone and menaquinone-4 were present in all milk samples: 5·84 (SD 2·31) AND 2·98 (sd 1·51) nmol/l (n31) respectively, in colostrum (day 4 sample). A strong correlation between the vitamers was found (r0·78,P<0·001). Breast-milk phylloquinone levels were raised in a dose-dependent manner: 4-, 12-, and 30-fold on day 16 for the 0·8, 2·0, and 4·0 mg group respectively. In addition, menaquinone-4 levels were higher: 2·5- (P<0·05) and 7-fold (P<0·001) in the 2·0 and 4·0 mg groups respectively. Plasma of supplemented subjects contained 3-, 5-, and 10-fold higher phylloquinone levels on day 16. Detectable menaquinone-4 was found in ten of thirty-one day 4 plasma samples. All day 16 plasma samples of the 4 mg supplemented group contained the vitamin. There was no correlation between the K-vitamers in plasma. Vitamin E and phylloquinone appear to differ in their distribution in breast milk, milk:plasma concentration ratios were ≤1 and 3–5 for vitamin E and phylloquinone respectively. The milk:plasma concentration ratio of menaquinone-4 was >10. In conclusion, dietary phylloquinone is a source of menaquinone-4 in breast milk. Phylloquinone supplementation to lactating mothers may be of benefit to the newborn infant, since both phylloquinone and menaquinone-4 are raised by supplementation.


Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2509
Author(s):  
Antonella Aresta ◽  
Gualtiero Milani ◽  
Maria Lisa Clodoveo ◽  
Carlo Franchini ◽  
Pietro Cotugno ◽  
...  

The absence of vitamin E from the diet can lead to cardiovascular disease, cancer, cataracts, and premature aging. Vitamin K deficiency can lead to bleeding disorders. These fat-soluble vitamins are important nutritional factors that can be determined in different methods in vegetables. In this work, the simultaneous determination of α-tocopherol, α-tocopheryl acetate, phylloquinone, and menaquinone-4 by gas chromatography–mass spectrometry (GC–MS) has been optimized using both direct injection and solid phase microextraction (SPME). Three different sample pre-treatment approaches based on: (A) solid–liquid–liquid–liquid extraction (SLE–LLE), (B) SLE, and (C) SPME were then applied to extract the target analytes from vegetables samples using menaquinone as internal standard. All the procedures allowed the determination of the target analytes in onion, carrot, celery, and curly kale samples. Similar results were obtained with the three different approaches, even if the one based on SPME offers the best performance, together with a reduced use of solvent, time consumption, and experimental complexity, which makes it the preferable option for industrial applications.


1976 ◽  
Vol 108 (4) ◽  
pp. 391-394 ◽  
Author(s):  
J. E. McFarlane

AbstractVitamin K1 added to a basic diet for the house cricket, Acheta domesticus (L.), significantly improves growth of male and female larvae. Growth is significantly better with 18.7 μg K1/g than it is with an equimolar amount of vitamin E. Unlike vitamin E, however, vitamin K1 is without effect on reproduction. Vitamins K3 and K5, and coumarin, have no effect or a slightly inhibiting effect on growth, and no effect on reproduction.


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