scholarly journals Retinal neurodegeneration and neuroinflammation in a SOD1 mouse model of ALS

2022 ◽  
Vol 100 (S267) ◽  
Author(s):  
María Pilar Rojas Lozano ◽  
Manuel Cadena Santoyo ◽  
Jose Antonio Fernández‐Albarral ◽  
Inés López‐Cuenca ◽  
Elena Salobrar‐García ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinal Neurodegeneration ◽  
Sod1 Mouse

Slowing disease progression in the SOD1 mouse model of ALS by blocking neuregulin-induced microglial activation

2018 ◽  
Vol 111 ◽  
pp. 118-126 ◽  
Author(s):  
Jianguo Liu ◽  
Elise Allender ◽  
Jiajing Wang ◽  
Eleanor H. Simpson ◽  
Jeffrey A. Loeb ◽  
...  
Keyword(s):  
Mouse Model ◽  
Disease Progression ◽  
Microglial Activation ◽  
Sod1 Mouse

scholarly journals Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS

Metallomics ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 1002-1011 ◽  
Author(s):  
J. B. Hilton ◽  
A. R. White ◽  
P. J. Crouch
Keyword(s):  
Central Nervous System ◽  
Amyotrophic Lateral Sclerosis ◽  
Nervous System ◽  
Mouse Model ◽  
Limited Capacity ◽  
Mutant Sod1 ◽  
The Central Nervous System ◽  
Sod1 Mouse ◽  
Lateral Sclerosis

It is unclear why ubiquitous expression of mutant SOD1 selectively affects the central nervous system in amyotrophic lateral sclerosis. Here we hypothesise that the central nervous system is primarily affected because, unlike other tissues, it has relatively limited capacity to satiate an increased requirement for Cu.

scholarly journals EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62342 ◽  
Author(s):  
Claire E. Le Pichon ◽  
Sara L. Dominguez ◽  
Hilda Solanoy ◽  
Hai Ngu ◽  
Nicholas Lewin-Koh ◽  
...  
Keyword(s):  
Mouse Model ◽  
Disease Progression ◽  
Egfr Inhibitor ◽  
Sod1 Mouse

Potassium channel abnormalities are consistent with early axon degeneration of motor axons in the G127X SOD1 mouse model of amyotrophic lateral sclerosis

2017 ◽  
Vol 292 ◽  
pp. 154-167 ◽  
Author(s):  
Rikke Maglemose ◽  
Anne Hedegaard ◽  
Janna Lehnhoff ◽  
Kristina Petrova Dimintiyanova ◽  
Mihai Moldovan ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Potassium Channel ◽  
Axon Degeneration ◽  
Motor Axons ◽  
Sod1 Mouse ◽  
Lateral Sclerosis

scholarly journals Spinal motoneurones are intrinsically more responsive in the adult G93A SOD1 mouse model of amyotrophic lateral sclerosis

2020 ◽  
Vol 598 (19) ◽  
pp. 4385-4403
Author(s):  
Dennis B. Jensen ◽  
Marion Kadlecova ◽  
Ilary Allodi ◽  
Claire F. Meehan
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
G93a Sod1 Mouse ◽  
Spinal Motoneurones ◽  
Sod1 Mouse ◽  
G93a Sod1 ◽  
Lateral Sclerosis
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