Assessment of Regional Systolic and Diastolic Myocardial Function Using Tissue Doppler and Strain Imaging in Dogs with Dilated Cardiomyopathy

2007 ◽  
Vol 21 (4) ◽  
pp. 719-730 ◽  
Author(s):  
Valérie Chetboul ◽  
Vassiliki Gouni ◽  
Carolina Carlos Sampedrano ◽  
Renaud Tissier ◽  
Francois Serres ◽  
...  
2016 ◽  
Vol 36 (9) ◽  
pp. 851-856
Author(s):  
Guilherme G. Pereira ◽  
Guilherme T. Goldfeder ◽  
Fernanda L. Yamaki ◽  
Valéria M.C. Oliveira ◽  
Maria Helena M.A. Larsson

Abstract: Dilated cardiomyopathy (DCM) is characterized by systolic myocardial dysfunction which is identified by low myocardial velocities obtained by pulsed tissue Doppler (PTD). However, increased preload is known to increase myocardial velocities which could overestimate myocardial function and turn dysfunction characterization into a challenge in dogs with DCM and congestive heart failure. To test the hypothesis that increased preload could hamper identification of low myocardial velocities in dogs with DCM and congestive heart failure the present study prospectively evaluated 32 English Cocker Spaniel dogs, being 16 with clinical DCM and 16 healthy for control purpose. The PTD analysis of regional velocities were performed in both longitudinal and radial myocardial displacements and systolic (Sm), early (Em) and late diastolic (Am) velocities were obtained in left ventricular free wall (LVFW) and interventricular septum (IVS). Peak radial subendocardial and subepicardial Sm velocities were lower in DCM group compared to control (0.065±0.018 vs. 0.102±0.020m/s and 0.059±0.014 vs. 0.094±0.025m/s respectively; p<0.001). Peak longitudinal Sm velocities were lower in basal and medial portions of LVFW (0.093±0.034 vs. 0.155±0.034m/s and 0.091±0.033 vs. 0.134±0.037m/s respectively; p<0.001) and IVS (0.063±0.021 vs. 0.136±0.039 and 0.066±0.026 vs. 0.104±0.032m/s respectively; p<0.001). Most of diastolic velocities were not significantly different between groups, although advanced myocardial disease and dysfunction are expected in DCM group. Reduction in systolic basal and medial longitudinal myocardial velocities and in radial myocardial velocities was the most significant PTD findings. Increased preload did not represent a problem to evaluate systolic dysfunction by PTD in English Cocker Spaniels with DCM, but influence of preload on assessment of diastolic velocities should be better elucidated.


2007 ◽  
Vol 14 (5) ◽  
pp. 522-529 ◽  
Author(s):  
Anke Thomas ◽  
Mathias Warm ◽  
Markus Hoopmann ◽  
Felix Diekmann ◽  
Thomas Fischer

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Woonggil Choi ◽  
Soohyun Kim ◽  
Seongill Woo ◽  
Deahyuk Kim ◽  
Keumsoo Park ◽  
...  

Objective: Functional mitral regurgitation (FMR) occurs commonly in patients with dilated cardiomyopathy (DCM). The aim of this study was to compare the roles of Left Ventricle(LV) dyssynchrony and geometric parameters of mitral apparatus as determinants of FMR in patients with DCM. Methods: Fourteen DCM patients without FMR and 15 DCM patients with FMR (ERO = 0.11 ± 0.029 cm 2 ) were enrolled. Effective regurgitant orifice (ERO) area and tissue Doppler-derived dyssynchrony index (DI: the standard deviation of time to peak myocardial systolic contraction of eight segments) were measured. The estimated DIs were corrected by the cycle length (CL) of each patient (cDI (%) = DI/CL*100). Using real-time 3D echocardiogrphy, mitral tenting area (MVT) and the degrees of displacement of anterior (APMD) and posterior (PPMD) papillary muscles were estimated. All geometric measurements were corrected (c) by the height of each patient. Results: There was no significant (p > 0.05) difference in LV Ejection Fraction and cLVEDV between two patient groups. cDI, cMVT, cAPMD and cPPMD significantly (p < 0.05) increased in the patient with FMR comparing with those in patients without FMR. cDI (r = 0.42), cMVT (r = 0.74), cAPMD (r = 0.63) and cPPMD (r = 0.64) showed significant (p < 0.05) correlations with ERO. cMVT was found to the strongest independent predictor of ERO with multivariate regression analysis, whereas cDI did not enter into the model. Conclusions: The degree of MV tenting rather than LV dyssynchrony was found to be the main determinant of FMR in DCM. However LV dyssynchrony also has a minor independent association with FMR.


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