Purification, crystallization and anticancer activity evaluation of the compound alternariol methyl ether from endophytic fungi Alternaria alternata

2019 ◽  
Vol 127 (5) ◽  
pp. 1468-1478 ◽  
Author(s):  
P. Palanichamy ◽  
S. Kannan ◽  
D. Murugan ◽  
P. Alagusundaram ◽  
M. Marudhamuthu
Keyword(s):  
Anticancer Activity ◽  
Endophytic Fungi ◽  
Methyl Ether ◽  
Alternaria Alternata ◽  
Alternariol Methyl Ether ◽  
Activity Evaluation

Production of Alternariol and Alternariol Methyl Ether by Alternaria alternata Grown on Fruits at Various Temperatures

2001 ◽  
Vol 64 (4) ◽  
pp. 528-532 ◽  
Author(s):  
V. H. TOURNAS ◽  
MICHAEL E. STACK
Keyword(s):  
Methyl Ether ◽  
Alternaria Alternata ◽  
Room Temperature ◽  
Toxin Production ◽  
Limited Growth ◽  
Fast Growing ◽  
Alternariol Methyl Ether ◽  
Moderate Growth ◽  
Golden Delicious ◽  
Toxigenic Strains

Two toxigenic strains of the fungus Alternaria alternata (ATCC 56836 and ATCC 66868) were grown on surface-disinfected, fresh, ripe fruits and tested for the production of alternariol (AOH) and alternariol methyl ether (AME). Examined fruits included strawberries; red and green seedless grapes; concord grapes; red delicious, golden delicious, and gala apples; and blueberries. After inoculation, fruits were incubated at 4, 10°C, or room temperature (approximately 21°C) for up to 3 weeks. At weekly intervals, duplicate samples were analyzed for AOH and AME by using liquid chromatography. Results indicated that A. alternata and its metabolites were not a major problem in strawberries due to the presence of fast-growing molds like Rhizopus and Botrytis that outgrew and possibly inhibited Alternaria. Both Alternaria strains showed limited growth on apples, although fast-growing molds were not present after surface disinfection; AOH and AME were produced only by the ATCC 56836 strain on the golden delicious and gala varieties, (ranging from <0.1 to 5 μg/g and <0.1 to 14 μg/g for AOH and AME, respectively). Restricted growth of both strains without toxin production occurred in blueberries, whereas moderate growth and AOH (<0.1 to 3,336 μg/g) and AME (<0.1 to 1,716 μg/g) production took place in grapes.

Synthesis and Antiinflammatoryand Anticancer Activity Evaluation of Some Condensed Pyrimidines

2000 ◽  
Vol 131 (5) ◽  
pp. 0501-0509 ◽  
Author(s):  
Sham M. Sondhi ◽  
Nidhi Singhal ◽  
Rajeshwar P. Verma ◽  
Sudershan K. Arora ◽  
Rakesh Shukla ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation

Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives

2010 ◽  
Vol 45 (2) ◽  
pp. 555-563 ◽  
Author(s):  
Sham M. Sondhi ◽  
Jaiveer Singh ◽  
Reshma Rani ◽  
P.P. Gupta ◽  
S.K. Agrawal ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Acridine Derivatives ◽  
Activity Evaluation ◽  
Anti Inflammatory

scholarly journals Synthesis and anticancer activity evaluation of naphthalene-substituted triazole spirodienones

2020 ◽  
pp. 113039
Author(s):  
Lan Luo ◽  
Jing Jing Jia ◽  
Qiu Zhong ◽  
Xue Zhong ◽  
Shilong Zheng ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation

scholarly journals Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation

2019 ◽  
Vol 141 (12) ◽  
pp. 4849-4860 ◽  
Author(s):  
Hem Raj Khatri ◽  
Bijay Bhattarai ◽  
Will Kaplan ◽  
Zhongzheng Li ◽  
Marcus John Curtis Long ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity ◽  
Activity Evaluation

Synthesis and anticancer activity evaluation of resveratrol–chalcone conjugates

MedChemComm ◽  
2014 ◽  
Vol 5 (4) ◽  
pp. 528 ◽  
Author(s):  
Deepak Kumar ◽  
K. Kranthi Raj ◽  
Sanjay V. Malhotra ◽  
Diwan S. Rawat
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation

Mycotoxins - Their Biosynthesis in Alternaria

1985 ◽  
Vol 48 (1) ◽  
pp. 80-91 ◽  
Author(s):  
E. E. STINSON
Keyword(s):  
Secondary Metabolites ◽  
Methyl Ether ◽  
Current View ◽  
Tenuazonic Acid ◽  
Alternariol Methyl Ether ◽  
Wide Assortment

Alternaria produce a wide assortment of toxic and nontoxic secondary metabolites. A brief summary of the numerous secondary metabolites of Alternaria and their toxicity is followed by a presentation of the current view of the polyketide biosynthetic mechanism and its application to the biosynthesis of these compounds. Possible mechanisms for the biosynthesis of alternariol, alternariol methyl ether, and other dibenzo-α-pyrones are presented, as well as mechanisms for the biosynthesis of tenuazonic acid and altertoxin I. Bioregulation of the production of these materials by light, heat, nutrients and NADPH production, and the role of mannitol in NADPH formation are also discussed.

Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: Synthesis and anticancer activity evaluation

2020 ◽  
Vol 104 ◽  
pp. 104309
Author(s):  
Anita Bułakowska ◽  
Jarosław Sławiński ◽  
Kamila Siedlecka-Kroplewska ◽  
Grzegorz Stasiłojć ◽  
Marcin Serocki ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation
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