Long-Term Effects of Low-Dose Spironolactone on Chronic Dialysis Patients: A Randomized Placebo-Controlled Study

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

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Acute and long-term effects of saxagliptin on a set of cardiovascular targets measured at fasting and post-prandially in obese patients with impaired glucose tolerance: a placebo-controlled study

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2021.06.017 ◽

2021 ◽

Author(s):

Amel Rezki ◽

Emmanuel Cosson ◽

Marinos Fysekidis ◽

Sabrina Chiheb ◽

Eric Vicaut ◽

...

Keyword(s):

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Controlled Study ◽

Obese Patients ◽

Long Term Effects

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Beneficial Long-Term Effects of Combined Oral/Topical Antioxidant Treatment with the Carotenoids Lutein and Zeaxanthin on Human Skin: A Double-Blind, Placebo-Controlled Study

Skin Pharmacology and Physiology ◽

10.1159/000101807 ◽

2007 ◽

Vol 20 (4) ◽

pp. 199-210 ◽

Cited By ~ 123

Author(s):

P. Palombo ◽

G. Fabrizi ◽

V. Ruocco ◽

E. Ruocco ◽

J. Fluhr ◽

...

Keyword(s):

Human Skin ◽

Controlled Study ◽

Long Term Effects ◽

Antioxidant Treatment ◽

Double Blind ◽

Double Blind Placebo

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The Immediate And Long-Term Effects of Shexiang Tongxin Dropping Pill On Coronary Slow Flow: Study Protocol For A Randomized Double-Blind Placebo-Controlled Trial

10.21203/rs.3.rs-467743/v1 ◽

2021 ◽

Author(s):

Birong Liu ◽

Yong Liu ◽

Liyong Ma ◽

Jia Liu ◽

Jingen Li ◽

...

Keyword(s):

Clinical Trial ◽

Blood Flow ◽

Blood Stasis ◽

Blood Stasis Syndrome ◽

Controlled Study ◽

Slow Flow ◽

Long Term Effects ◽

Coagulation Function ◽

Coronary Slow Flow

Abstract Background: Coronary slow flow (CSF) is a phenomenon characterized by delayed contrast medium progression in angiography in the absence of obstructive coronary epicardial disease. However, there is currently no definite effective therapy. A small sample self-controlled study had suggested an immediate improvement in coronary slow blood flow by Shexiang Tongxin Dropping Pills (STDP). But high-quality evidences on drug dosage, medication cycle and long-term effects are still lacking while the mechanism of STDP remains unclear. Methods: This study is a randomized, double-blinded, and placebo-controlled clinical trial. A total of 64 CSF patients diagnosed by coronary angiography will be randomly allocated into the test group, using STDP, and the control group, using placebo. The main efficacy indicators for immediate effects include thrombolysis in myocardial infarction (TIMI) blood flow grading and corrected TIMI frame count. Long-term effects will be evaluated by the comparison of cardiac radionuclide score, and patient condition such as angina readmission rate and angina scale. The safety indicators include a routine complete blood count, liver and renal function test, cardiac markers (including TnI, CK-MB, Myo), NT-proBNP, coagulation function, 12-lead electrocardiogram, and echocardiography. All adverse events during the trial will be recorded. Moreover, endothelial factors (including ET-1, NO, eNOS, iNOS), inflammatory factors (including adropin, IL-6, IL-1, IL-18, TNF-α, Lp-PLA2, hs-CRP) will be observed. Blood stasis syndrome (including platelet activation factors such as CD62 and CD63, coagulation function and blood stasis syndrome score) will be evaluated.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000035167. Registered on August 2, 2020. http://www.chictr.org.cn/showproj.aspx?proj=57349

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Long-term effects of simulated microgravity and/or chronic exposure to low-dose gamma radiation on behavior and blood–brain barrier integrity

npj Microgravity ◽

10.1038/npjmgrav.2016.19 ◽

2016 ◽

Vol 2 (1) ◽

Cited By ~ 13

Author(s):

John A Bellone ◽

Peter S Gifford ◽

Nina C Nishiyama ◽

Richard E Hartman ◽

Xiao Wen Mao

Keyword(s):

Gamma Radiation ◽

Blood Brain Barrier ◽

Chronic Exposure ◽

Low Dose ◽

Simulated Microgravity ◽

Brain Barrier ◽

Long Term Effects ◽

Barrier Integrity ◽

Blood Brain Barrier Integrity

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Long Term Effects of Small Doses of 1,25 Dihydroxycholecalciferol in Dialysis Patients

Vitamin D. Basic Research and its Clinical Application ◽

10.1515/9783112330029-137 ◽

1979 ◽

pp. 803-806

Author(s):

B. Hochman ◽

V. Gura ◽

G. Boner ◽

A. Weiss ◽

A. J. Olah ◽

...

Keyword(s):

Long Term Effects ◽

Dialysis Patients ◽

Small Doses

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First Insights into the Effect of Low-Dose X-Ray Irradiation in Adipose-Derived Stem Cells

International Journal of Molecular Sciences ◽

10.3390/ijms20236075 ◽

2019 ◽

Vol 20 (23) ◽

pp. 6075 ◽

Cited By ~ 2

Author(s):

Annemarie Schröder ◽

Stephan Kriesen ◽

Guido Hildebrandt ◽

Katrin Manda

Keyword(s):

Stem Cells ◽

Low Dose ◽

Dose Range ◽

Adipose Derived Stem Cells ◽

Long Term Effects ◽

Low Dose Radiation ◽

Term Survival ◽

Cell Therapies ◽

Dose Radiation

(1) Background: Emerging interest of physicians to use adipose-derived stem cells (ADSCs) for regenerative therapies and the fact that low-dose irradiation (LD-IR ≤ 0.1 Gy) has been reported to enhance the proliferation of several human normal and bone-marrow stem cells, but not that of tumor cells, lead to the idea of improving stem cell therapies via low-dose radiation. Therefore, the aim of this study was to investigate unwanted side effects, as well as proliferation-stimulating mechanisms of LD-IR on ADSCs. (2) Methods: To avoid donor specific effects, ADSCs isolated from mamma reductions of 10 donors were pooled and used for the radiobiological analysis. The clonogenic survival assay was used to classify the long-term effects of low-dose radiation in ADSCs. Afterwards, cytotoxicity and genotoxicity, as well as the effect of irradiation on proliferation of ADSCs were investigated. (3) Results: LD (≤ 0.1 Gy) of ionizing radiation promoted the proliferation and survival of ADSCs. Within this dose range neither geno- nor cytotoxic effects were detectable. In contrast, greater doses within the dose range of >0.1–2.0 Gy induced residual double-strand breaks and reduced the long-term survival, as well as the proliferation rate of ADSCs. (4) Conclusions: Our data suggest that ADSCs are resistant to LD-IR. Furthermore, LD-IR could be a possible mediator to improve approaches of stem cells in the field of regenerative medicine.

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Long-Term Changes of Symptoms of Anxiety, Depression, and Fatigue in Cancer Patients 6 Months After the End of Yoga Therapy

Integrative Cancer Therapies ◽

10.1177/1534735418822096 ◽

2019 ◽

Vol 18 ◽

pp. 153473541882209 ◽

Cited By ~ 3

Author(s):

Anna Lundt ◽

Elisabeth Jentschke

Keyword(s):

Cancer Patients ◽

Controlled Study ◽

Life Questionnaire ◽

Long Term Effects ◽

European Organization ◽

Yoga Therapy ◽

Randomized Controlled ◽

Long Term Changes ◽

Anxiety Depression

Background: Symptoms of anxiety, depression, and cancer-related fatigue are commonly associated with cancer. Cancer patients increasingly use complementary and alternative treatments, such as yoga, to cope with psychological and physical impairments. In the present article, long-term changes of anxiety, depression, and fatigue in cancer are examined 6 months after a yoga intervention. Method: We used an observational design based on a randomized controlled study in cancer patients with mixed diagnoses to evaluate long-term changes of symptoms of anxiety, depression, and fatigue 6 months after the end of yoga therapy. We measured anxiety symptoms with the Generalized Anxiety Disorder scale (GAD-7), depressive symptoms with the Patient Health Questionnaire–2 (PHQ-2), and fatigue with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire–Fatigue Scale (EORTC QLQ-FA13). Yoga therapy was provided in yoga classes of 60 minutes each once a week for 8 weeks in total. The exercises provided contained both body and breathing activities as well as meditation. Results: A total of 58 patients participated in the study. Six months after the end of yoga therapy, symptoms of anxiety, depression, and fatigue were significantly reduced compared with baseline. However, symptoms of anxiety and fatigue slightly increased during the follow-up period, whereas symptoms of depression remained stable. Conclusion: Our results are promising and support the integration of yoga interventions in supportive cancer treatment concepts but should be confirmed by randomized controlled trials. Long-term effects of yoga therapy on cancer patients should be the subject of further research.

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