scholarly journals Role of elevated serum uric acid levels at the onset of overt nephropathy in the risk for renal function decline in patients with type 2 diabetes

2014 ◽  
Vol 6 (1) ◽  
pp. 98-104 ◽  
Author(s):  
Kentaro Tanaka ◽  
Shigeko Hara ◽  
Masakazu Hattori ◽  
Ken Sakai ◽  
Yukiko Onishi ◽  
...  
2017 ◽  
Vol 31 (12) ◽  
pp. 1691-1697 ◽  
Author(s):  
Alessandro Mantovani ◽  
Riccardo Rigolon ◽  
Isabella Pichiri ◽  
Giovanni Morani ◽  
Stefano Bonapace ◽  
...  

2013 ◽  
Vol 112 (4) ◽  
pp. 499-504 ◽  
Author(s):  
Filippo Valbusa ◽  
Lorenzo Bertolini ◽  
Stefano Bonapace ◽  
Luciano Zenari ◽  
Giacomo Zoppini ◽  
...  

Author(s):  
Khalef Lefsih ◽  
Dalila Dahmani ◽  
Rabah Cherrad ◽  
Souad Lalaoui ◽  
Sarah Amrar

Aim: The main objective of our work was to assess the relationship between type 2 diabetes, hyperuricemia and dyslipidemia in the population of Tizi-Ouzou. By evaluating the relationship between hyperuricemia and some blood lipid parameters, we thus establish, in type 2 diabetes, the correlation between uremia and these lipid parameters. Subjects and methods: The survey was carried out by means of an individual questionnaire. We excluded from our study pregnant women, patients with cancer, patients with end-stage renal disease and subjects who did not respond to the questionnaire. Results: Serum uric acid level increased with age (p = 0.025). Hyperuricemia was associated with heart disease (p = 0.0007). All patients with gout presented an elevated serum uric acid (p = 0.000001). Dyslipidemia was more common in patients with elevated serum uric acid levels (p = 0.0008). Triglyceridemia was significantly associated with hyperuricemia (p = 0.025). The relationship between type 2 diabetes and glomerular filtration rate was not significant, while the latter was decreased in patients with elevated serum uric acid levels (p = 0.0001). In, stratified analysis, age was effect modifier, the age-dependent results make us understand that resistance to insulin constitutes a significant factor of hyperuricemia. Conclusion: The association between hyperuricemia and dyslipidemia in type 2 diabetes emphasizes that insulin resistance acts on both lipid parameters and uricemia. A diet correcting dyslipidemia may also correct the uricemia. Keywords: Hyperuricemia, diabetes type 2, dyslipidemia, lipoproteins.


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