Successful treatment of severe acute respiratory distress syndrome due to Group A streptococcus induced toxic shock syndrome in the third trimester of pregnancy‐effectiveness of venoarterial extracorporeal membrane oxygenation: A case report

2019 ◽  
Vol 46 (1) ◽  
pp. 167-172 ◽  
Author(s):  
Daisuke Ichikawa ◽  
Seung Chik Jwa ◽  
Takeru Seto ◽  
Norihito Tarumoto ◽  
Yoshiyuki Haga ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Case Report ◽  
Toxic Shock Syndrome ◽  
Distress Syndrome ◽  
Group A Streptococcus ◽  
Toxic Shock ◽  
Third Trimester ◽  
The Third ◽  
Venoarterial Extracorporeal Membrane Oxygenation ◽  
Group A

Group A streptococcal toxic shock syndrome with extremely aggressive course in the third trimester

2010 ◽  
Vol 36 (4) ◽  
pp. 852-855 ◽  
Author(s):  
Takashi Sugiyama ◽  
Takumi Kobayashi ◽  
Kenji Nagao ◽  
Tsuyoshi Hatada ◽  
Hideo Wada ◽  
...  
Keyword(s):  
Toxic Shock Syndrome ◽  
Streptococcal Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Third Trimester ◽  
The Third ◽  
Group A

Streptococcal toxic shock syndrome occurring in the third trimester of pregnancy: A case report

2017 ◽  
Vol 43 (10) ◽  
pp. 1639-1643
Author(s):  
Mohamad Irani ◽  
Rodney McLaren ◽  
Richard H. Savel ◽  
Oksana Bogatyryova ◽  
Fady Khoury-Collado
Keyword(s):  
Case Report ◽  
Toxic Shock Syndrome ◽  
Streptococcal Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Third Trimester ◽  
The Third

scholarly journals AR-12 Has a Bactericidal Activity and a Synergistic Effect with Gentamicin against Group A Streptococcus

2021 ◽  
Vol 22 (21) ◽  
pp. 11617
Author(s):  
Nina Tsao ◽  
Ya-Chu Chang ◽  
Sung-Yuan Hsieh ◽  
Tang-Chi Li ◽  
Ching-Chen Chiu ◽  
...  
Keyword(s):  
Toxic Shock Syndrome ◽  
Group A Streptococcus ◽  
Streptococcal Toxic Shock Syndrome ◽  
Invasive Infection ◽  
Toxic Shock ◽  
Spherical Structures ◽  
Group A ◽  
Bacteria And Fungi

Streptococcus pyogenes (group A Streptococcus (GAS) is an important human pathogen that can cause severe invasive infection, such as necrotizing fasciitis and streptococcal toxic shock syndrome. The mortality rate of streptococcal toxic shock syndrome ranges from 20% to 50% in spite of antibiotics administration. AR-12, a pyrazole derivative, has been reported to inhibit the infection of viruses, intracellular bacteria, and fungi. In this report, we evaluated the bactericidal activities and mechanisms of AR-12 on GAS infection. Our in vitro results showed that AR-12 dose-dependently reduced the GAS growth, and 2.5 μg/mL of AR-12 significantly killed GAS within 2 h. AR-12 caused a remarkable reduction in nucleic acid and protein content of GAS. The expression of heat shock protein DnaK and streptococcal exotoxins was also inhibited by AR-12. Surveys of the GAS architecture by scanning electron microscopy revealed that AR-12-treated GAS displayed incomplete septa and micro-spherical structures protruding out of cell walls. Moreover, the combination of AR-12 and gentamicin had a synergistic antibacterial activity against GAS replication for both in vitro and in vivo infection. Taken together, these novel findings obtained in this study may provide a new therapeutic strategy for invasive GAS infection.

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